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    Ccnb3 cyclin B3 [ Mus musculus (house mouse) ]

    Gene ID: 209091, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Ccnb3provided by MGI
    Official Full Name
    cyclin B3provided by MGI
    Primary source
    MGI:MGI:2183443
    See related
    Ensembl:ENSMUSG00000051592 AllianceGenome:MGI:2183443
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in mitotic cell cycle phase transition and regulation of cyclin-dependent protein serine/threonine kinase activity. Predicted to act upstream of or within cell division and meiotic cell cycle. Predicted to be located in nuclear speck. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in centrosome; cytoplasm; and nucleus. Is expressed in ovary and seminiferous tubule. Orthologous to human CCNB3 (cyclin B3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    Location:
    X A1.1; X 3.13 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (6845890..6907894, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (6979652..7041635, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 5430428K19 gene Neighboring gene shroom family member 4 Neighboring gene STARR-seq mESC enhancer starr_46656 Neighboring gene STARR-seq mESC enhancer starr_46657 Neighboring gene STARR-seq mESC enhancer starr_46658 Neighboring gene diacylglycerol kinase kappa Neighboring gene STARR-seq mESC enhancer starr_46659 Neighboring gene STARR-seq mESC enhancer starr_46660 Neighboring gene A kinase anchor protein 4 Neighboring gene ribosomal protein L23a pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cyclin B3 implements timely vertebrate oocyte arrest for fertilization. Bouftas N, et al. Dev Cell, 2022 Oct 10. PMID 36182686
    2. Recurrent pregnancy loss in mice lacking the X-linked Ccnb3 gene†. Chotiner JY, et al. Biol Reprod, 2022 Mar 19. PMID 34850816, Free PMC Article
    3. Degradation of Ccnb3 is essential for maintenance of MII arrest in oocyte. Meng TG, et al. Biochem Biophys Res Commun, 2020 Jan 1. PMID 31640856
    4. Cyclin B3 is dispensable for mouse spermatogenesis. Karasu ME, et al. Chromosoma, 2019 Sep. PMID 31446450, Free PMC Article
    5. Cyclin B3 is required for metaphase to anaphase transition in oocyte meiosis I. Li Y, et al. J Cell Biol, 2019 May 6. PMID 30770433, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Recurrent pregnancy loss in mice lacking the X-linked Ccnb3 genedagger.
      Title: Recurrent pregnancy loss in mice lacking the X-linked Ccnb3 gene†.
    2. Our findings underscore the requirement for CCNB3 in female meiosis and suggest that ZGA-specific functions of CCNB3 observed in invertebrate species are not likely conserved in mammals. The Ccnb3-deficient mouse model is similar to a human infertility condition - recurrent pregnancy loss (RPL).
      Title: Recurrent pregnancy loss in mice lacking the X-linked Ccnb3 gene†.
    3. The results indicate that Ccnb3 plays a critical regulatory role in MII arrest and exit in mouse oocytes.
      Title: Degradation of Ccnb3 is essential for maintenance of MII arrest in oocyte.
    4. we found that males lacking cyclin B3 are fertile and show no detectable defects in spermatogenesis based on histological analysis of seminiferous tubules.
      Title: Cyclin B3 is dispensable for mouse spermatogenesis.
    5. Cyclin B3 is an M-phase cyclin which promotes anaphase I onset in oocyte meiosis.
      Title: Cyclin B3 promotes anaphase I onset in oocyte meiosis.
    6. Depletion of cyclin B3 inhibits metaphase-anaphase transition as indicated by a well-sustained MI spindle and cyclin B1 expression in meiotic oocytes.
      Title: Cyclin B3 controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes.
    7. cloning of a partial cDNA and localized mRNA to leptotene and zygotene spermatocytes
      Title: Characterization and expression of mammalian cyclin b3, a prepachytene meiotic cyclin.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic cell cycle phase transition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cyclin-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cyclin-dependent protein kinase holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    G2/mitotic-specific cyclin-B3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_183015.4 → NP_898836.2  G2/mitotic-specific cyclin-B3

      See identical proteins and their annotated locations for NP_898836.2

      Status: VALIDATED

      Source sequence(s)
      AL671962
      Consensus CDS
      CCDS29961.1
      UniProtKB/Swiss-Prot
      Q810T2, Q810T3, Q8VDC8
      UniProtKB/TrEMBL
      A2AEP2
      Related
      ENSMUSP00000111418.2, ENSMUST00000115752.8
      Conserved Domains (2) summary
      COG5024
      Location:1054 → 1372
      COG5024; Cyclin [Cell division and chromosome partitioning]
      pfam00134
      Location:1138 → 1263
      Cyclin_N; Cyclin, N-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      6845890..6907894 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017318448.1 → XP_017173937.1  G2/mitotic-specific cyclin-B3 isoform X1

      UniProtKB/Swiss-Prot
      Q810T2, Q810T3, Q8VDC8
      UniProtKB/TrEMBL
      A2AEP2
      Related
      ENSMUSP00000052272.8, ENSMUST00000056725.8
      Conserved Domains (2) summary
      COG5024
      Location:1054 → 1372
      COG5024; Cyclin [Cell division and chromosome partitioning]
      pfam00134
      Location:1138 → 1263
      Cyclin_N; Cyclin, N-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q810T2.2 GenPept UniProtKB/Swiss-Prot:Q810T2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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