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    Lrrc47 leucine rich repeat containing 47 [ Mus musculus (house mouse) ]

    Gene ID: 72946, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Lrrc47provided by MGI
    Official Full Name
    leucine rich repeat containing 47provided by MGI
    Primary source
    MGI:MGI:1920196
    See related
    Ensembl:ENSMUSG00000029028 AllianceGenome:MGI:1920196
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1185; 2900010D03Rik
    Summary
    Predicted to enable RNA binding activity and phenylalanine-tRNA ligase activity. Is expressed in central nervous system and retina. Orthologous to human LRRC47 (leucine rich repeat containing 47). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary adult (RPKM 63.9), thymus adult (RPKM 42.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 E2; 4 83.79 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (154096260..154105969)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (154011803..154021512)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene DNA fragmentation factor, beta subunit Neighboring gene centrosomal protein 104 Neighboring gene predicted gene, 31566 Neighboring gene small integral membrane protein 1 Neighboring gene coiled-coil domain containing 27 Neighboring gene transformation related protein 73 Neighboring gene STARR-seq mESC enhancer starr_12227 Neighboring gene STARR-seq mESC enhancer starr_12228 Neighboring gene predicted gene, 26036

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of atrogin-1-targeted proteins during the myostatin-induced skeletal muscle wasting. Lokireddy S, et al. Am J Physiol Cell Physiol, 2012 Sep 1. PMID 22673621
    2. Oct4 links multiple epigenetic pathways to the pluripotency network. Ding J, et al. Cell Res, 2012 Jan. PMID 22083510, Free PMC Article
    3. The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis. Menon S, et al. Mol Biol Cell, 2021 Feb 15. PMID 33378226, Free PMC Article
    4. Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics. Federspiel JD, et al. Mol Cell Proteomics, 2019 Aug 9. PMID 31040226, Free PMC Article
    5. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    contributes_to phenylalanine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in phenylalanyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat-containing protein 47

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201226.1 → NP_957678.1  leucine-rich repeat-containing protein 47

      See identical proteins and their annotated locations for NP_957678.1

      Status: VALIDATED

      Source sequence(s)
      AK013512, AK129306, BU148242, BU514662
      Consensus CDS
      CCDS19006.1
      UniProtKB/Swiss-Prot
      Q3U380, Q505F5, Q6ZPW2, Q9CUZ0
      UniProtKB/TrEMBL
      B1AX98, E9PV22
      Related
      ENSMUSP00000030894.9, ENSMUST00000030894.15
      Conserved Domains (4) summary
      smart00873
      Location:332 → 504
      B3_4; B3/4 domain
      cd00116
      Location:34 → 260
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:54 → 78
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:77 → 143
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      154096260..154105969
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q505F5.1 GenPept UniProtKB/Swiss-Prot:Q505F5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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