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    Exoc2 exocyst complex component 2 [ Mus musculus (house mouse) ]

    Gene ID: 66482, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Exoc2provided by MGI
    Official Full Name
    exocyst complex component 2provided by MGI
    Primary source
    MGI:MGI:1913732
    See related
    Ensembl:ENSMUSG00000021357 AllianceGenome:MGI:1913732
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sec5; Sec5l1; Gm29675; 2410030I24Rik
    Summary
    Enables protein N-terminus binding activity and small GTPase binding activity. Predicted to be involved in Golgi to plasma membrane transport; exocytosis; and regulation of entry of bacterium into host cell. Predicted to act upstream of or within positive regulation of exocytosis. Predicted to be located in plasma membrane. Predicted to be part of exocyst. Is expressed in several structures, including early conceptus and genitourinary system. Orthologous to human EXOC2 (exocyst complex component 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 9.5), CNS E14 (RPKM 7.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Exoc2 in Genome Data Viewer
    Location:
    13 A3.2; 13
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (30968421..31162082, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (30789516..30974096, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5386 Neighboring gene dual specificity phosphatase 22 Neighboring gene STARR-seq mESC enhancer starr_34069 Neighboring gene STARR-positive B cell enhancer ABC_E10787 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:30853140-30853323 Neighboring gene interferon regulatory factor 4 Neighboring gene STARR-positive B cell enhancer ABC_E11781 Neighboring gene HUS1 checkpoint clamp component B Neighboring gene predicted gene, 35302 Neighboring gene RIKEN cDNA 4930401O12 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Exocyst sec5 regulates exocytosis of newcomer insulin granules underlying biphasic insulin secretion. Xie L, et al. PLoS One, 2013. PMID 23844030, Free PMC Article
    2. Structure of the GTPase-binding domain of Sec5 and elucidation of its Ral binding site. Mott HR, et al. J Biol Chem, 2003 May 9. PMID 12624092
    3. Salmonella-directed recruitment of new membrane to invasion foci via the host exocyst complex. Nichols CD, et al. Curr Biol, 2010 Jul 27. PMID 20579884, Free PMC Article
    4. Involvement of Exoc3l, a protein structurally related to the exocyst subunit Sec6, in insulin secretion. Saito T, et al. Biomed Res, 2008 Apr. PMID 18480549
    5. Arl13b and the exocyst interact synergistically in ciliogenesis. Seixas C, et al. Mol Biol Cell, 2016 Jan 15. PMID 26582389, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Exocyst sec5 regulates exocytosis of newcomer insulin granules underlying biphasic insulin secretion.
      Title: Exocyst sec5 regulates exocytosis of newcomer insulin granules underlying biphasic insulin secretion.
    2. the structure of the Ral-binding domain of Sec5
      Title: Structure of the GTPase-binding domain of Sec5 and elucidation of its Ral binding site.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi to plasma membrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Golgi to plasma membrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in membrane fission NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in mitotic cytokinesis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of exocytosis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of entry of bacterium into host cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle docking involved in exocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle docking involved in exocytosis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in vesicle tethering involved in exocytosis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of exocyst IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of exocyst ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of exocyst NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of exocyst TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    exocyst complex component 2
    Names
    SEC5 homolog
    SEC5-like 1
    exocyst complex component Sec5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360093.1 → NP_001347022.1  exocyst complex component 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL606764, AL645745
      Consensus CDS
      CCDS26420.1
      UniProtKB/Swiss-Prot
      Q9D4H1
      Related
      ENSMUSP00000100010.2, ENSMUST00000102946.8
      Conserved Domains (2) summary
      pfam01833
      Location:8 → 91
      TIG; IPT/TIG domain
      pfam15469
      Location:200 → 376
      Sec5; Exocyst complex component Sec5

    2. NM_001424702.1 → NP_001411631.1  exocyst complex component 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL606764, AL645745

    3. NM_025588.2 → NP_079864.1  exocyst complex component 2 isoform 1

      See identical proteins and their annotated locations for NP_079864.1

      Status: VALIDATED

      Source sequence(s)
      BC049102
      Consensus CDS
      CCDS26420.1
      UniProtKB/Swiss-Prot
      Q9D4H1
      Related
      ENSMUSP00000021785.7, ENSMUST00000021785.8
      Conserved Domains (2) summary
      pfam01833
      Location:8 → 91
      TIG; IPT/TIG domain
      pfam15469
      Location:200 → 376
      Sec5; Exocyst complex component Sec5

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      30968421..31162082 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011244328.3 → XP_011242630.1  exocyst complex component 2 isoform X1

      Conserved Domains (2) summary
      pfam01833
      Location:8 → 91
      TIG; IPT/TIG domain
      pfam15469
      Location:200 → 376
      Sec5; Exocyst complex component Sec5

    2. XM_036158115.1 → XP_036014008.1  exocyst complex component 2 isoform X1

      Conserved Domains (2) summary
      pfam01833
      Location:8 → 91
      TIG; IPT/TIG domain
      pfam15469
      Location:200 → 376
      Sec5; Exocyst complex component Sec5

    3. XM_036158116.1 → XP_036014009.1  exocyst complex component 2 isoform X1

      Conserved Domains (2) summary
      pfam01833
      Location:8 → 91
      TIG; IPT/TIG domain
      pfam15469
      Location:200 → 376
      Sec5; Exocyst complex component Sec5

    4. XM_036158117.1 → XP_036014010.1  exocyst complex component 2 isoform X2

      UniProtKB/Swiss-Prot
      Q9D4H1
      Conserved Domains (2) summary
      pfam01833
      Location:8 → 91
      TIG; IPT/TIG domain
      pfam15469
      Location:200 → 376
      Sec5; Exocyst complex component Sec5

    5. XM_017315565.3 → XP_017171054.1  exocyst complex component 2 isoform X4

      Conserved Domains (2) summary
      pfam01833
      Location:8 → 91
      TIG; IPT/TIG domain
      pfam15469
      Location:200 → 374
      Sec5; Exocyst complex component Sec5

    6. XM_017315564.3 → XP_017171053.1  exocyst complex component 2 isoform X3

      Conserved Domains (2) summary
      pfam01833
      Location:8 → 91
      TIG; IPT/TIG domain
      pfam15469
      Location:200 → 374
      Sec5; Exocyst complex component Sec5
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D4H1.1 GenPept UniProtKB/Swiss-Prot:Q9D4H1

    Gene LinkOut

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