Jcad junctional cadherin 5 associated [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Jcadprovided by MGI
Official Full Name: junctional cadherin 5 associatedprovided by MGI
Primary source: MGI:MGI:2685174
See related: Ensembl:ENSMUSG00000033960 AllianceGenome:MGI:2685174
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm328; mKIAA1462; 1110056P05Rik; 9430020K01Rik
Summary: Involved in positive regulation of sprouting angiogenesis. Located in cell-cell junction. Is expressed in meninges; tail mesenchyme; and vertebral axis musculature. Orthologous to human JCAD (junctional cadherin 5 associated). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in lung adult (RPKM 23.0), cortex adult (RPKM 11.1) and 20 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 18 A1; 18 3.01 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (4590775..4682869)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (4590792..4682869)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

JCAD deficiency delayed liver regenerative repair through the Hippo-YAP signalling pathway.
Title: JCAD deficiency delayed liver regenerative repair through the Hippo-YAP signalling pathway.
JCAD promotes arterial thrombosis through PI3K/Akt modulation: a translational study.
Title: JCAD promotes arterial thrombosis through PI3K/Akt modulation: a translational study.
A key role for the novel coronary artery disease gene JCAD in atherosclerosis via shear stress mechanotransduction.
Title: A key role for the novel coronary artery disease gene JCAD in atherosclerosis via shear stress mechanotransduction.
JCAD has a redundant functional role in physiological angiogenesis but serves a pivotal role in pathological angiogenic process after birth.
Title: Targeted Disruption of JCAD (Junctional Protein Associated With Coronary Artery Disease)/KIAA1462, a Coronary Artery Disease-Associated Gene Product, Inhibits Angiogenic Processes In Vitro and In Vivo.
These results indicate that JCAD is a component of VE-cadherin-based cell-cell junctions in endothelial cells. This study also suggests the implication of endothelial cell-cell adhesion in coronary artery disease.
Title: A coronary artery disease-associated gene product, JCAD/KIAA1462, is a novel component of endothelial cell-cell junctions.

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (2)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of vascular endothelial growth factor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
located_in adherens junction	ISO Inferred from Sequence Orthology more info
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in ruffle membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in ruffle membrane	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: junctional cadherin 5-associated protein

Names: junctional protein associated with coronary artery disease

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081963.1 → NP_001075432.1 junctional cadherin 5-associated protein

See identical proteins and their annotated locations for NP_001075432.1

Status: VALIDATED

Source sequence(s)

AC147227, AK220394, BU757028

Consensus CDS

CCDS37719.1

UniProtKB/Swiss-Prot

Q5DTX6

UniProtKB/TrEMBL

B7ZN02

Related

ENSMUSP00000038613.6, ENSMUST00000037029.7

Conserved Domains (1) summary

pfam15351
Location:1 → 1309

JCAD; Junctional protein associated with coronary artery disease

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

4590775..4682869

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006525904.4 → XP_006525967.1 junctional cadherin 5-associated protein isoform X1

See identical proteins and their annotated locations for XP_006525967.1

UniProtKB/Swiss-Prot

Q5DTX6

UniProtKB/TrEMBL

B7ZN02

Related

ENSMUSP00000157313.2, ENSMUST00000234153.2

Conserved Domains (1) summary

pfam15351
Location:1 → 1309

JCAD; Junctional protein associated with coronary artery disease
XM_006525903.4 → XP_006525966.1 junctional cadherin 5-associated protein isoform X1

See identical proteins and their annotated locations for XP_006525966.1

UniProtKB/Swiss-Prot

Q5DTX6

UniProtKB/TrEMBL

B7ZN02

Conserved Domains (1) summary

pfam15351
Location:1 → 1309

JCAD; Junctional protein associated with coronary artery disease