Mon1a MON1 homolog A, secretory traffciking associated [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mon1aprovided by MGI
Official Full Name: MON1 homolog A, secretory traffciking associatedprovided by MGI
Primary source: MGI:MGI:1920075
See related: Ensembl:ENSMUSG00000032583 AllianceGenome:MGI:1920075
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2810468K17Rik
Summary: Predicted to enable guanyl-nucleotide exchange factor activity. Acts upstream of or within cellular iron ion homeostasis and protein secretion. Predicted to be part of Mon1-Ccz1 complex. Orthologous to human MON1A (MON1 homolog A, secretory trafficking associated). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in duodenum adult (RPKM 31.1), small intestine adult (RPKM 27.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 F1; 9 59.07 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (107765282..107780338)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (107888083..107903139)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genetic interactions between Cp, Mon1a, and the Slc40a1 locus are involved in iron metabolism.
Title: Epistasis in iron metabolism: complex interactions between Cp, Mon1a, and Slc40a1 loci and tissue iron in mice.
a role for Mon1a in anterograde trafficking through the secretory apparatus.
Title: Mon1a protein acts in trafficking through the secretory apparatus.
data identify SAND-1 (Mon1) and CCZ-1 (Ccz1) as critical and evolutionarily conserved components regulating the processing of ingested apoptotic cell corpses
Title: Identification of two evolutionarily conserved genes regulating processing of engulfed apoptotic cells.
Study presents evidence that Mon1a is involved in trafficking of ferroportin, the major mammalian iron exporter, to the surface of iron-recycling macrophages.
Title: Genetic variation in Mon1a affects protein trafficking and modifies macrophage iron loading in mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D9Dcr103 (e-PCR), detects polymorphism
- UniSTS:499005

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within establishment of localization in cell	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intracellular iron ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein secretion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein targeting to vacuole	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of Mon1-Ccz1 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Mon1-Ccz1 complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: vacuolar fusion protein MON1 homolog A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_028369.3 → NP_082645.1 vacuolar fusion protein MON1 homolog A

See identical proteins and their annotated locations for NP_082645.1

Status: VALIDATED

Source sequence(s)

AK013387, AW045198, BY064239

Consensus CDS

CCDS23508.1

UniProtKB/TrEMBL

A0A0R4J0D5, A0A0R4J2D4

Related

ENSMUSP00000035202.3, ENSMUST00000035202.4

Conserved Domains (1) summary

pfam03164
Location:155 → 555

Mon1; Trafficking protein Mon1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

107765282..107780338

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017313611.2 → XP_017169100.1 vacuolar fusion protein MON1 homolog A isoform X1

Conserved Domains (1) summary

pfam03164
Location:32 → 345

Mon1; Trafficking protein Mon1