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    Adamtsl2 ADAMTS-like 2 [ Mus musculus (house mouse) ]

    Gene ID: 77794, updated on 21-Apr-2024

    Summary

    Official Symbol
    Adamtsl2provided by MGI
    Official Full Name
    ADAMTS-like 2provided by MGI
    Primary source
    MGI:MGI:1925044
    See related
    Ensembl:ENSMUSG00000036040 AllianceGenome:MGI:1925044
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    tcp-1; A930008K15Rik
    Summary
    Enables microfibril binding activity. Acts upstream of or within extracellular matrix organization; lobar bronchus epithelium development; and negative regulation of transforming growth factor beta receptor signaling pathway. Located in extracellular matrix and extracellular region. Is expressed in several structures, including cardiovascular system; limb; lung; musculoskeletal system; and tail mesenchyme. Used to study geleophysic dysplasia 1. Human ortholog(s) of this gene implicated in geleophysic dysplasia 1. Orthologous to human ADAMTSL2 (ADAMTS like 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in lung adult (RPKM 24.7), spleen adult (RPKM 14.5) and 15 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    Location:
    2 A3; 2 19.22 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (26969348..26998993)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (27079336..27108981)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene 13398 Neighboring gene myomaker, myoblast fusion factor Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:26934889-26935076 Neighboring gene predicted gene, 36882 Neighboring gene family with sequence similarity 163, member B Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:26977601-26977932 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:26981648-26981757 Neighboring gene dopamine beta hydroxylase, opposite strand

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    ADAMTS-like protein 2
    Names
    TSP1-repeat-containing protein 1
    TSP1-repeats-containing protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029981.2NP_084257.1  ADAMTS-like protein 2 precursor

      See identical proteins and their annotated locations for NP_084257.1

      Status: VALIDATED

      Source sequence(s)
      AB096928, AI844377, AL845266
      Consensus CDS
      CCDS15824.1
      UniProtKB/Swiss-Prot
      Q3U0C8, Q7TSK7
      UniProtKB/TrEMBL
      A1A5B7
      Related
      ENSMUSP00000088774.7, ENSMUST00000091233.7
      Conserved Domains (4) summary
      smart00209
      Location:50106
      TSP1; Thrombospondin type 1 repeats
      pfam05986
      Location:216330
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:922953
      PLAC; PLAC (protease and lacunin) domain
      pfam19030
      Location:804860
      TSP1_ADAMTS; Thrombospondin type 1 domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      26969348..26998993
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498439.4XP_006498502.1  ADAMTS-like protein 2 isoform X3

      Conserved Domains (2) summary
      smart00209
      Location:50106
      TSP1; Thrombospondin type 1 repeats
      pfam05986
      Location:216330
      ADAM_spacer1; ADAM-TS Spacer 1
    2. XM_036162721.1XP_036018614.1  ADAMTS-like protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q3U0C8, Q7TSK7
      UniProtKB/TrEMBL
      A1A5B7
      Conserved Domains (4) summary
      smart00209
      Location:50106
      TSP1; Thrombospondin type 1 repeats
      pfam05986
      Location:216330
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:922953
      PLAC; PLAC (protease and lacunin) domain
      pfam19030
      Location:804860
      TSP1_ADAMTS; Thrombospondin type 1 domain
    3. XM_030252238.2XP_030108098.1  ADAMTS-like protein 2 isoform X2

      Conserved Domains (3) summary
      smart00209
      Location:576625
      TSP1; Thrombospondin type 1 repeats
      pfam05986
      Location:841
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:633664
      PLAC; PLAC (protease and lacunin) domain