Myo1a myosin IA [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Myo1aprovided by MGI
Official Full Name: myosin IAprovided by MGI
Primary source: MGI:MGI:107732
See related: Ensembl:ENSMUSG00000025401 AllianceGenome:MGI:107732
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Myhl; BBM-I
Summary: Enables actin filament binding activity. Acts upstream of or within microvillus assembly. Located in several cellular components, including basal plasma membrane; brush border; and lateral plasma membrane. Is expressed in several structures, including inner ear and intestine. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 48 and sensorineural hearing loss. Orthologous to human MYO1A (myosin IA). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in large intestine adult (RPKM 245.0), small intestine adult (RPKM 149.0) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 D3; 10 74.62 cM

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (127539306..127556809)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (127703436..127720940)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Myo1a and Myo6 play essential roles in response to intestinal mucosal injury
Title: Restoration of cytoskeletal and membrane tethering defects but not defects in membrane trafficking in the intestinal brush border of mice lacking both myosin Ia and myosin VI.
The data indicates that Myo1a is an important regulator of CFTR traffic and anion transport in the brush border membrane of villus enterocytes.
Title: Myosin Ia is required for CFTR brush border membrane trafficking and ion transport in the mouse small intestine.
Data suggest that Myo1d may be the primary compensating class I myosin in the Myo1a KO model; they also suggest that dynamics govern the localization and function of different yet closely related myosins that target common actin structures.
Title: Differential localization and dynamics of class I myosins in the enterocyte microvillus.
These studies show that class I myosins directly control the mechanical properties of the cell membrane; they also position these motor proteins as master regulators of cellular events involving membrane deformation.
Title: Control of cell membrane tension by myosin-I.
Actin filaments and myosin I alpha cooperate with microtubules for the movement of lysosomes
Title: Actin filaments and myosin I alpha cooperate with microtubules for the movement of lysosomes.
RT-PCR analysis of RNA extracted from the inner ear and cochlea of mice helped in the evaluation of MYO1A expression.
Title: Multiple mutations of MYO1A, a cochlear-expressed gene, in sensorineural hearing loss.
critical multifunctional component of the enterocyte, required for maintaining the normal composition and highly ordered structure of the brush border
Title: Myosin-1a is critical for normal brush border structure and composition.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IDA Inferred from Direct Assay more info	PubMed
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables cytoskeletal motor activity	IEA Inferred from Electronic Annotation more info
enables microfilament motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament-based movement	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell projection organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within microvillus assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein localization	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of sound	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory perception of sound	ISO Inferred from Sequence Orthology more info
involved_in vesicle localization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basal plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in brush border	IBA Inferred from Biological aspect of Ancestor more info
located_in brush border	IDA Inferred from Direct Assay more info	PubMed
located_in brush border	ISO Inferred from Sequence Orthology more info
located_in cell leading edge	ISO Inferred from Sequence Orthology more info
located_in cortical actin cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
part_of filamentous actin	ISO Inferred from Sequence Orthology more info
located_in growth cone	ISO Inferred from Sequence Orthology more info
located_in lateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in lateral plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in microvillus	IBA Inferred from Biological aspect of Ancestor more info
located_in microvillus	IDA Inferred from Direct Assay more info	PubMed
located_in microvillus	ISO Inferred from Sequence Orthology more info
part_of myosin complex	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane raft	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: unconventional myosin-Ia

Names: BBMI; MIHC; brush border myosin 1; brush border myosin I; myosin I heavy chain; myosin, heavy polypeptide-like (110kD); myosin-Ia

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081219.2 → NP_001074688.1 unconventional myosin-Ia

See identical proteins and their annotated locations for NP_001074688.1

Status: VALIDATED

Source sequence(s)

AC160970, AF009960, AK008176, CF929471

Consensus CDS

CCDS36083.1

UniProtKB/Swiss-Prot

B2RW65, O88329

Related

ENSMUSP00000078540.6, ENSMUST00000079590.7

Conserved Domains (3) summary

smart00015
Location:742 → 764

IQ; Calmodulin-binding motif

cd01378
Location:22 → 681

MYSc_Myo1; class I myosin, motor domain

pfam06017
Location:847 → 1042

Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

127539306..127556809

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006513859.4 → XP_006513922.1 unconventional myosin-Ia isoform X1

See identical proteins and their annotated locations for XP_006513922.1

UniProtKB/Swiss-Prot

B2RW65, O88329

Conserved Domains (3) summary

smart00015
Location:742 → 764

IQ; Calmodulin-binding motif

cd01378
Location:22 → 681

MYSc_Myo1; class I myosin, motor domain

pfam06017
Location:847 → 1042

Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
XM_006513860.5 → XP_006513923.1 unconventional myosin-Ia isoform X1

See identical proteins and their annotated locations for XP_006513923.1

UniProtKB/Swiss-Prot

B2RW65, O88329

Conserved Domains (3) summary

smart00015
Location:742 → 764

IQ; Calmodulin-binding motif

cd01378
Location:22 → 681

MYSc_Myo1; class I myosin, motor domain

pfam06017
Location:847 → 1042

Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding