Stpg4 sperm tail PG rich repeat containing 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Stpg4provided by MGI
Official Full Name: sperm tail PG rich repeat containing 4provided by MGI
Primary source: MGI:MGI:1922717
See related: Ensembl:ENSMUSG00000036557 AllianceGenome:MGI:1922717
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GSE; 1700011E24Rik
Summary: Enables chromatin binding activity and histone binding activity. Involved in DNA demethylation of male pronucleus and positive regulation of DNA demethylation. Acts upstream of or within C-5 methylation of cytosine. Located in cytoplasm; germinal vesicle; and pronucleus. Orthologous to human STPG4 (sperm-tail PG-rich repeat containing 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward testis adult (RPKM 34.4) See more
Orthologs: human all
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Genomic context

Location:: 17 E4; 17 57.38 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (87696998..87735526, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (87389570..87428081, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GSE is a maternal factor involved in active DNA demethylation in zygotes.
Title: GSE is a maternal factor involved in active DNA demethylation in zygotes.
findings suggest that GSE protein may play a role in the establishment of nuclear totipotency and may be associated with early lineage specification.
Title: Expression and subcellular localization of GSE protein in germ cells and preimplantation embryos.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation

General gene information

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Markers

D17Mit130 (e-PCR), detects polymorphism
- UniSTS:127962

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within 5-methylcytosine catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in epigenetic programing of male pronucleus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_positive_effect epigenetic programing of male pronucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epigenetic programing of male pronucleus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA demethylation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in female germ cell nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in female pronucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in female pronucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in germinal vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in germinal vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in male germ cell nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in male pronucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in male pronucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein STPG4

Names: gonad-specific expression gene protein; sperm-tail PG-rich repeat-containing protein 4; uncharacterized protein C2orf61 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.