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    Rexo5 RNA exonuclease 5 [ Mus musculus (house mouse) ]

    Gene ID: 434234, updated on 5-Mar-2024

    Summary

    Official Symbol
    Rexo5provided by MGI
    Official Full Name
    RNA exonuclease 5provided by MGI
    Primary source
    MGI:MGI:1919402
    See related
    Ensembl:ENSMUSG00000030924 AllianceGenome:MGI:1919402
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2610020H08Rik
    Summary
    Predicted to enable exonuclease activity. Predicted to be located in nucleolus. Predicted to be active in nucleus. Is expressed in brain. Orthologous to human REXO5 (RNA exonuclease 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis adult (RPKM 4.4), CNS E11.5 (RPKM 2.0) and 19 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    Location:
    7 F2; 7 64.21 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (119393331..119488130)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (119794117..119880443)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57786 Neighboring gene acyl-CoA synthetase medium-chain family member 3 Neighboring gene exoribonuclease 2 Neighboring gene STARR-seq mESC enhancer starr_20039 Neighboring gene defective in cullin neddylation 1 domain containing 3 Neighboring gene STARR-positive B cell enhancer ABC_E3747 Neighboring gene STARR-seq mESC enhancer starr_20040 Neighboring gene LYR motif containing 1 Neighboring gene STARR-seq mESC enhancer starr_20041 Neighboring gene dynein, axonemal, heavy chain 3 Neighboring gene predicted gene, 53369

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC59529

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    RNA exonuclease 5
    Names
    exonuclease NEF-sp

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004187.1NP_001004187.1  RNA exonuclease 5 isoform 1

      See identical proteins and their annotated locations for NP_001004187.1

      Status: VALIDATED

      Source sequence(s)
      BC053445
      Consensus CDS
      CCDS21787.1
      UniProtKB/TrEMBL
      Q7TSF9
      Related
      ENSMUSP00000033218.9, ENSMUST00000033218.15
      Conserved Domains (2) summary
      cl10012
      Location:225317
      DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
      cl17169
      Location:424462
      RRM_SF; RNA recognition motif (RRM) superfamily
    2. NM_001370778.1NP_001357707.1  RNA exonuclease 5 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC122423, AC164158
      UniProtKB/TrEMBL
      D3YW29
      Related
      ENSMUSP00000102130.2, ENSMUST00000106520.9
      Conserved Domains (2) summary
      cd06145
      Location:225373
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      cl17169
      Location:490560
      RRM_SF; RNA recognition motif (RRM) superfamily
    3. NM_028129.2NP_082405.1  RNA exonuclease 5 isoform 2

      See identical proteins and their annotated locations for NP_082405.1

      Status: VALIDATED

      Source sequence(s)
      AC122423, AC164158
      Consensus CDS
      CCDS21788.1
      UniProtKB/TrEMBL
      D3Z3J7
      Related
      ENSMUSP00000081694.3, ENSMUST00000084644.3
      Conserved Domains (2) summary
      cd06145
      Location:33181
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      cl17169
      Location:298368
      RRM_SF; RNA recognition motif (RRM) superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      119393331..119488130
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241845.4XP_011240147.1  RNA exonuclease 5 isoform X1

      UniProtKB/TrEMBL
      D3YW29
      Conserved Domains (2) summary
      cd06145
      Location:225373
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      cl17169
      Location:490560
      RRM_SF; RNA recognition motif (RRM) superfamily
    2. XM_006507994.5XP_006508057.1  RNA exonuclease 5 isoform X5

      UniProtKB/TrEMBL
      D3YW29
      Conserved Domains (2) summary
      cd06145
      Location:225373
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      cl17169
      Location:490560
      RRM_SF; RNA recognition motif (RRM) superfamily
    3. XM_036153220.1XP_036009113.1  RNA exonuclease 5 isoform X4

      UniProtKB/TrEMBL
      D3YW29
      Conserved Domains (2) summary
      cd06145
      Location:225373
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      cl17169
      Location:555625
      RRM_SF; RNA recognition motif (RRM) superfamily
    4. XM_006507991.5XP_006508054.1  RNA exonuclease 5 isoform X2

      See identical proteins and their annotated locations for XP_006508054.1

      UniProtKB/TrEMBL
      D3YW29
      Conserved Domains (2) summary
      cd06145
      Location:225373
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      cl17169
      Location:490560
      RRM_SF; RNA recognition motif (RRM) superfamily
    5. XM_030242744.2XP_030098604.1  RNA exonuclease 5 isoform X2

      UniProtKB/TrEMBL
      D3YW29
      Conserved Domains (2) summary
      cd06145
      Location:225373
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      cl17169
      Location:490560
      RRM_SF; RNA recognition motif (RRM) superfamily
    6. XM_006507990.5XP_006508053.1  RNA exonuclease 5 isoform X2

      See identical proteins and their annotated locations for XP_006508053.1

      UniProtKB/TrEMBL
      D3YW29
      Conserved Domains (2) summary
      cd06145
      Location:225373
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      cl17169
      Location:490560
      RRM_SF; RNA recognition motif (RRM) superfamily
    7. XM_030242746.2XP_030098606.1  RNA exonuclease 5 isoform X6

      UniProtKB/TrEMBL
      D3YW29
      Conserved Domains (2) summary
      cd06145
      Location:225373
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      cl17169
      Location:490560
      RRM_SF; RNA recognition motif (RRM) superfamily
    8. XM_006507992.5XP_006508055.1  RNA exonuclease 5 isoform X3

      UniProtKB/TrEMBL
      D3YW29
      Conserved Domains (2) summary
      cd06145
      Location:225373
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      cl17169
      Location:490560
      RRM_SF; RNA recognition motif (RRM) superfamily
    9. XM_006508000.5XP_006508063.1  RNA exonuclease 5 isoform X15

      See identical proteins and their annotated locations for XP_006508063.1

      Conserved Domains (2) summary
      cd06145
      Location:225373
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      cl17169
      Location:490528
      RRM_SF; RNA recognition motif (RRM) superfamily
    10. XM_006507998.5XP_006508061.1  RNA exonuclease 5 isoform X12

      UniProtKB/TrEMBL
      D3YW29
      Conserved Domains (2) summary
      cd06145
      Location:225373
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      cl17169
      Location:490560
      RRM_SF; RNA recognition motif (RRM) superfamily
    11. XM_036153228.1XP_036009121.1  RNA exonuclease 5 isoform X13

      Conserved Domains (2) summary
      cd06145
      Location:225373
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      cl17169
      Location:555598
      RRM_SF; RNA recognition motif (RRM) superfamily
    12. XM_006507999.5XP_006508062.1  RNA exonuclease 5 isoform X15

      See identical proteins and their annotated locations for XP_006508062.1

      Conserved Domains (2) summary
      cd06145
      Location:225373
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      cl17169
      Location:490528
      RRM_SF; RNA recognition motif (RRM) superfamily
    13. XM_036153221.1XP_036009114.1  RNA exonuclease 5 isoform X7

      UniProtKB/TrEMBL
      A0A1Z1GHX5
      Conserved Domains (2) summary
      cl10012
      Location:225317
      DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
      cl17169
      Location:424494
      RRM_SF; RNA recognition motif (RRM) superfamily
    14. XM_036153227.1XP_036009120.1  RNA exonuclease 5 isoform X11

      Conserved Domains (2) summary
      cd06145
      Location:33181
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      cl17169
      Location:298368
      RRM_SF; RNA recognition motif (RRM) superfamily
    15. XM_036153229.1XP_036009122.1  RNA exonuclease 5 isoform X14

      Conserved Domains (2) summary
      cd06145
      Location:145293
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      cl17169
      Location:410480
      RRM_SF; RNA recognition motif (RRM) superfamily
    16. XM_036153226.1XP_036009119.1  RNA exonuclease 5 isoform X11

      Conserved Domains (2) summary
      cd06145
      Location:33181
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      cl17169
      Location:298368
      RRM_SF; RNA recognition motif (RRM) superfamily
    17. XM_036153224.1XP_036009117.1  RNA exonuclease 5 isoform X10

      UniProtKB/TrEMBL
      D3YW29
      Conserved Domains (2) summary
      cd06145
      Location:126274
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      cl17169
      Location:391461
      RRM_SF; RNA recognition motif (RRM) superfamily
    18. XM_036153223.1XP_036009116.1  RNA exonuclease 5 isoform X9

      UniProtKB/TrEMBL
      D3YW29
      Conserved Domains (2) summary
      cd06145
      Location:143291
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      cl17169
      Location:408478
      RRM_SF; RNA recognition motif (RRM) superfamily
    19. XM_036153225.1XP_036009118.1  RNA exonuclease 5 isoform X11

      Conserved Domains (2) summary
      cd06145
      Location:33181
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      cl17169
      Location:298368
      RRM_SF; RNA recognition motif (RRM) superfamily
    20. XM_036153222.1XP_036009115.1  RNA exonuclease 5 isoform X8

      UniProtKB/TrEMBL
      D3YW29
      Conserved Domains (2) summary
      cd06145
      Location:145293
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      cl17169
      Location:410480
      RRM_SF; RNA recognition motif (RRM) superfamily

    RNA

    1. XR_869733.4 RNA Sequence

    2. XR_378253.5 RNA Sequence

    3. XR_378258.5 RNA Sequence

      Related
      ENSMUST00000133758.9
    4. XR_004934130.1 RNA Sequence

    5. XR_004934132.1 RNA Sequence

    6. XR_004934131.1 RNA Sequence

    7. XR_004934133.1 RNA Sequence

    8. XR_004934134.1 RNA Sequence

    9. XR_004934135.1 RNA Sequence

    10. XR_004934136.1 RNA Sequence

    11. XR_004934137.1 RNA Sequence

    12. XR_004934138.1 RNA Sequence