Myl6b myosin, light polypeptide 6B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Myl6bprovided by MGI
Official Full Name: myosin, light polypeptide 6Bprovided by MGI
Primary source: MGI:MGI:1917789
See related: Ensembl:ENSMUSG00000039824 AllianceGenome:MGI:1917789
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MLC1SA; 5730437E04Rik
Summary: Predicted to enable cytoskeletal motor activity. Predicted to be a structural constituent of muscle. Predicted to be involved in muscle filament sliding and skeletal muscle tissue development. Predicted to be part of unconventional myosin complex. Is expressed in central nervous system; diaphragm; limb mesenchyme; skeletal musculature; and tail paraxial mesenchyme. Orthologous to human MYL6B (myosin light chain 6B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in limb E14.5 (RPKM 7.3), CNS E18 (RPKM 7.2) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 D3; 10 76.77 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (128330026..128334554, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (128494157..128498685, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables cytoskeletal motor activity	TAS Traceable Author Statement more info	PubMed
enables structural constituent of muscle	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of muscle	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in muscle contraction	TAS Traceable Author Statement more info	PubMed
involved_in muscle filament sliding	TAS Traceable Author Statement more info	PubMed
involved_in skeletal muscle tissue development	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of myosin II complex	IBA Inferred from Biological aspect of Ancestor more info
part_of myosin complex	TAS Traceable Author Statement more info	PubMed
part_of unconventional myosin complex	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: myosin light chain 6B

Names: myosin light chain 1 slow a; smooth muscle and nonmuscle myosin light chain alkali 6B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172259.1 → NP_758463.1 myosin light chain 6B

See identical proteins and their annotated locations for NP_758463.1

Status: PROVISIONAL

Source sequence(s)

BC037527

Consensus CDS

CCDS24279.1

UniProtKB/Swiss-Prot

Q8CI43

Related

ENSMUSP00000026428.4, ENSMUST00000026428.4

Conserved Domains (4) summary

PTZ00184
Location:57 → 206

PTZ00184; calmodulin; Provisional

smart00054
Location:67 → 95

EFh; EF-hand, calcium binding motif

cd00051
Location:150 → 204

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cl08302
Location:67 → 131

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...