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    Marchf3 membrane associated ring-CH-type finger 3 [ Mus musculus (house mouse) ]

    Gene ID: 320253, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Marchf3provided by MGI
    Official Full Name
    membrane associated ring-CH-type finger 3provided by MGI
    Primary source
    MGI:MGI:2443667
    See related
    Ensembl:ENSMUSG00000032656 AllianceGenome:MGI:2443667
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    March3; MARCH-III; 6330411I15Rik; A530081L18Rik
    Summary
    Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in protein ubiquitination. Predicted to act upstream of or within endocytosis. Predicted to be located in endosome and lysosome. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and integumental system. Orthologous to human MARCHF3 (membrane associated ring-CH-type finger 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in liver E14.5 (RPKM 13.9), liver E14 (RPKM 12.2) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    18 D3; 18 30.92 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (56894788..57058587, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (56761716..56925515, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10992 Neighboring gene predicted gene, 41738 Neighboring gene lamin B1 Neighboring gene STARR-seq mESC enhancer starr_44677 Neighboring gene predicted gene 15345 Neighboring gene VISTA enhancer mm109 Neighboring gene STARR-positive B cell enhancer ABC_E5663 Neighboring gene STARR-positive B cell enhancer ABC_E1959 Neighboring gene ribosomal protein S3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_44682 Neighboring gene predicted gene, 34632 Neighboring gene RIKEN cDNA C330018D20 gene Neighboring gene predicted gene 10536

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. MARCH3 attenuates IL-1β-triggered inflammation by mediating K48-linked polyubiquitination and degradation of IL-1RI. Lin H, et al. Proc Natl Acad Sci U S A, 2018 Dec 4. PMID 30442668, Free PMC Article
    2. The membrane-associated ubiquitin ligases MARCH2 and MARCH3 target IL-5 receptor alpha to negatively regulate eosinophilic airway inflammation. Zeng LW, et al. Cell Mol Immunol, 2022 Oct. PMID 35982175, Free PMC Article
    3. MARCH3 negatively regulates IL-3-triggered inflammatory response by mediating K48-linked polyubiquitination and degradation of IL-3Rα. Feng L, et al. Signal Transduct Target Ther, 2022 Jan 24. PMID 35075102, Free PMC Article
    4. Integrated microarray and ChIP analysis identifies multiple Foxa2 dependent target genes in the notochord. Tamplin OJ, et al. Dev Biol, 2011 Dec 15. PMID 22008794
    5. A global genomic transcriptional code associated with CNS-expressed genes. Bailey PJ, et al. Exp Cell Res, 2006 Oct 1. PMID 16919269

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The membrane-associated ubiquitin ligases MARCH2 and MARCH3 target IL-5 receptor alpha to negatively regulate eosinophilic airway inflammation.
      Title: The membrane-associated ubiquitin ligases MARCH2 and MARCH3 target IL-5 receptor alpha to negatively regulate eosinophilic airway inflammation.
    2. MARCH3 negatively regulates IL-3-triggered inflammatory response by mediating K48-linked polyubiquitination and degradation of IL-3Ralpha.
      Title: MARCH3 negatively regulates IL-3-triggered inflammatory response by mediating K48-linked polyubiquitination and degradation of IL-3Rα.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (1)  1 citation

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC130167, MGC130168

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase MARCHF3
    Names
    E3 ubiquitin-protein ligase MARCH3
    RING-type E3 ubiquitin transferase MARCH3
    RING-type E3 ubiquitin transferase MARCHF3
    membrane-associated RING finger protein 3
    membrane-associated RING-CH protein III
    membrane-associated ring finger (C3HC4) 3
    NP_001361156.1
    NP_001361157.1
    NP_796089.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001374227.1 → NP_001361156.1  E3 ubiquitin-protein ligase MARCHF3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC109152, AC158763
      Consensus CDS
      CCDS89244.1
      UniProtKB/TrEMBL
      F8WJC4
      Related
      ENSMUSP00000047946.7, ENSMUST00000035278.7
      Conserved Domains (1) summary
      cd16699
      Location:70 → 120
      RING_CH-C4HC3_MARCH2_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH2, MARCH3, and similar proteins

    2. NM_001374228.1 → NP_001361157.1  E3 ubiquitin-protein ligase MARCHF3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC109152, AC158763
      Conserved Domains (1) summary
      cd16699
      Location:70 → 120
      RING_CH-C4HC3_MARCH2_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH2, MARCH3, and similar proteins

    3. NM_177115.3 → NP_796089.1  E3 ubiquitin-protein ligase MARCHF3 isoform 2

      See identical proteins and their annotated locations for NP_796089.1

      Status: VALIDATED

      Source sequence(s)
      AC109152, AC158763
      Consensus CDS
      CCDS29262.1
      UniProtKB/Swiss-Prot
      Q3KNK5, Q8BRX9
      Related
      ENSMUSP00000099976.2, ENSMUST00000102912.8
      Conserved Domains (1) summary
      cd16699
      Location:70 → 120
      RING_CH-C4HC3_MARCH2_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH2, MARCH3, and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      56894788..57058587 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BRX9.1 GenPept UniProtKB/Swiss-Prot:Q8BRX9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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