Hoxa3 homeobox A3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hoxa3provided by MGI
Official Full Name: homeobox A3provided by MGI
Primary source: MGI:MGI:96175
See related: Ensembl:ENSMUSG00000079560 AllianceGenome:MGI:96175
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mo-10; Hox-1.5
Summary: Enables DNA-binding transcription factor activity and HMG box domain binding activity. Acts upstream of or within several processes, including animal organ development; blood vessel remodeling; and glossopharyngeal nerve morphogenesis. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including branchial arch; embryo mesenchyme; genitourinary system; gut; and nervous system. Used to study DiGeorge syndrome. Orthologous to human HOXA3 (homeobox A3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in colon adult (RPKM 3.5), ovary adult (RPKM 2.4) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 B3; 6 25.4 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (52146039..52190316, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (52169059..52213067, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Translation inhibitory elements from Hoxa3 and Hoxa11 mRNAs use uORFs for translation inhibition.
Title: Translation inhibitory elements from Hoxa3 and Hoxa11 mRNAs use uORFs for translation inhibition.
HOX paralogs selectively convert binding of ubiquitous transcription factors into tissue-specific patterns of enhancer activation.
Title: HOX paralogs selectively convert binding of ubiquitous transcription factors into tissue-specific patterns of enhancer activation.
HoxA3 induced upregulation of Jag1 ligand in endothelial cells, which led to cis-inhibition of the Notch pathway, rendering the HE nonresponsive to Notch signals.
Title: Notch activation is required for downregulation of HoxA3-dependent endothelial cell phenotype during blood formation.
Our findings suggest a role for Hox a3 protein activity in promoting M1-to-M2-like phenotypic switching via interactions with myeloid transcription factors and provide insight into mechanisms regulating this process in diabetic wound healing
Title: Enforced Expression of Hoxa3 Inhibits Classical and Promotes Alternative Activation of Macrophages In Vitro and In Vivo.
ultiple roles for HOXA3 in regulating thymus and parathyroid differentiation and morphogenesis in mouse.
Title: Multiple roles for HOXA3 in regulating thymus and parathyroid differentiation and morphogenesis in mouse.
Studies indicate that Hoxa3 promotes proliferation and differentiation of HSC/Ps into Gr-1+CD11b+ myeloid cells.
Title: Hoxa3 promotes the differentiation of hematopoietic progenitor cells into proangiogenic Gr-1+CD11b+ myeloid cells.
Data show that HoxA3 restrains haematopoietic differentiation of the earliest endothelial progenitors, and induces reversion of the earliest haematopoietic progenitors into CD41-negative endothelial cells.
Title: HoxA3 is an apical regulator of haemogenic endothelium.
demonstrate that zebrafish hoxa3a (zfhoxa3a) expressed from the mouse Hoxa3 locus can substitute for mouse Hoxa3 in some tissues, but has distinct or null phenotypes in others.
Title: Mouse and zebrafish Hoxa3 orthologues have nonequivalent in vivo protein function.
HOXA3 accelerates wound repair by mobilizing endothelial progenitor cells and attenuating the excessive inflammatory response of chronic wounds.
Title: HOXA3 modulates injury-induced mobilization and recruitment of bone marrow-derived cells.
homeobox gene hoxa3 is essential for the formation of the carotid body in the mouse embryos
Title: Homeobox gene hoxa3 is essential for the formation of the carotid body in the mouse embryos.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (9) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Hoxa3 (e-PCR), detects polymorphism
- UniSTS:143367

Hoxa5 (e-PCR), detects polymorphism
- UniSTS:143368

Hoxa5 (e-PCR), detects polymorphism
- UniSTS:143369

Hoxa6 (e-PCR), detects polymorphism
- UniSTS:143370

REN100444 (e-PCR)
- UniSTS:425241

MARC_6217-6218:992007117:1 (e-PCR)
- UniSTS:231213

UniSTS:57649 (e-PCR)
- UniSTS:57649

Hoxa3 (e-PCR), detects polymorphism
- UniSTS:536641

UniSTS:467536 (e-PCR)
- UniSTS:467536

Hoxa3 (e-PCR), detects polymorphism
- UniSTS:467536

UniSTS:467537 (e-PCR)
- UniSTS:467537

Hoxa6 (e-PCR), detects polymorphism
- UniSTS:467537

REN100507 (e-PCR)
- UniSTS:425304

NoName (e-PCR)
- UniSTS:548185

Hoxa5 (e-PCR), detects polymorphism
- UniSTS:239193

REN100511 (e-PCR)
- UniSTS:425308

REN100512 (e-PCR)
- UniSTS:425309

REN100522 (e-PCR)
- UniSTS:425319

REN100523 (e-PCR)
- UniSTS:425320

REN100524 (e-PCR)
- UniSTS:425321

NoName (e-PCR)
- UniSTS:489066

Hoxa4 (e-PCR), detects polymorphism
- UniSTS:515967

ECD16077 (e-PCR)
- UniSTS:297092

PMC316811P1 (e-PCR)
- UniSTS:273050

ECD03747 (e-PCR)
- UniSTS:284827

stSG609349 (e-PCR)
- UniSTS:449442

AV206827 (e-PCR)
- UniSTS:179372

NoName (e-PCR)
- UniSTS:235446

REN100363 (e-PCR)
- UniSTS:425160

REN100364 (e-PCR)
- UniSTS:425161

REN100365 (e-PCR)
- UniSTS:425162

Y00208 (e-PCR)
- UniSTS:125907

REN100375 (e-PCR)
- UniSTS:425172

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables HMG box domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within animal organ formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within animal organ morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in anterior/posterior pattern specification	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within anterior/posterior pattern specification	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within blood vessel remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cartilage development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic skeletal system development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in embryonic skeletal system morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within embryonic skeletal system morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of gene expression	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within glossopharyngeal nerve morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within glossopharyngeal nerve morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within parathyroid gland development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of parathyroid gland development	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within positive regulation of stem cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within specification of animal organ position	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of stem cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within thymus development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within thymus development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of thymus development	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within thyroid gland development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within thyroid gland development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: homeobox protein Hox-A3

Names: homeo box A3; homeobox protein Hox-1.5; homeobox protein MO-10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010452.4 → NP_034582.1 homeobox protein Hox-A3

See identical proteins and their annotated locations for NP_034582.1

Status: VALIDATED

Source sequence(s)

AC015583, AC091106

Consensus CDS

CCDS20140.1

UniProtKB/Swiss-Prot

P02831, Q4V9Z8, Q61197

Related

ENSMUSP00000110077.3, ENSMUST00000114434.9

Conserved Domains (3) summary

COG5576
Location:182 → 309

COG5576; Homeodomain-containing transcription factor [Transcription]

pfam00046
Location:196 → 249

Homeobox; Homeobox domain

pfam13293
Location:378 → 441

DUF4074; Domain of unknown function (DUF4074)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

52146039..52190316 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017321404.3 → XP_017176893.1 homeobox protein Hox-A3 isoform X1

UniProtKB/Swiss-Prot

P02831, Q4V9Z8, Q61197

Conserved Domains (3) summary

COG5576
Location:182 → 309

COG5576; Homeodomain-containing transcription factor [Transcription]

pfam00046
Location:196 → 249

Homeobox; Homeobox domain

pfam13293
Location:378 → 441

DUF4074; Domain of unknown function (DUF4074)
XM_017321403.2 → XP_017176892.1 homeobox protein Hox-A3 isoform X1

UniProtKB/Swiss-Prot

P02831, Q4V9Z8, Q61197

Conserved Domains (3) summary

COG5576
Location:182 → 309

COG5576; Homeodomain-containing transcription factor [Transcription]

pfam00046
Location:196 → 249

Homeobox; Homeobox domain

pfam13293
Location:378 → 441

DUF4074; Domain of unknown function (DUF4074)
XM_017321402.2 → XP_017176891.1 homeobox protein Hox-A3 isoform X1

UniProtKB/Swiss-Prot

P02831, Q4V9Z8, Q61197

Conserved Domains (3) summary

COG5576
Location:182 → 309

COG5576; Homeodomain-containing transcription factor [Transcription]

pfam00046
Location:196 → 249

Homeobox; Homeobox domain

pfam13293
Location:378 → 441

DUF4074; Domain of unknown function (DUF4074)
XM_011241225.4 → XP_011239527.1 homeobox protein Hox-A3 isoform X1

See identical proteins and their annotated locations for XP_011239527.1

UniProtKB/Swiss-Prot

P02831, Q4V9Z8, Q61197

Conserved Domains (3) summary

COG5576
Location:182 → 309

COG5576; Homeodomain-containing transcription factor [Transcription]

pfam00046
Location:196 → 249

Homeobox; Homeobox domain

pfam13293
Location:378 → 441

DUF4074; Domain of unknown function (DUF4074)