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    Nosip nitric oxide synthase interacting protein [ Mus musculus (house mouse) ]

    Gene ID: 66394, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Nosipprovided by MGI
    Official Full Name
    nitric oxide synthase interacting proteinprovided by MGI
    Primary source
    MGI:MGI:1913644
    See related
    Ensembl:ENSMUSG00000003421 AllianceGenome:MGI:1913644
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CGI-25; 2310061K06Rik
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in negative regulation of nitric-oxide synthase activity. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be active in nucleus. Used to study holoprosencephaly. Orthologous to human NOSIP (nitric oxide synthase interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary adult (RPKM 33.0), thymus adult (RPKM 26.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 B3; 7 29.1 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44711840..44727927)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45062417..45078503)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene proline rich 12 Neighboring gene STARR-positive B cell enhancer ABC_E6541 Neighboring gene STARR-positive B cell enhancer ABC_E2235 Neighboring gene proline-rich Gla (G-carboxyglutamic acid) polypeptide 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:52317657-52317840 Neighboring gene reticulocalbin 3, EF-hand calcium binding domain Neighboring gene Fc fragment of IgG receptor and transporter

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Nosip functions during vertebrate eye and cranial cartilage development. Flach H, et al. Dev Dyn, 2018 Sep. PMID 30055071
    2. Developmental neurogenesis in mouse and Xenopus is impaired in the absence of Nosip. Hoffmeister M, et al. Dev Biol, 2017 Sep 1. PMID 28663132
    3. The ubiquitin E3 ligase NOSIP modulates protein phosphatase 2A activity in craniofacial development. Hoffmeister M, et al. PLoS One, 2014. PMID 25546391, Free PMC Article
    4. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
    5. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Rudra D, et al. Nat Immunol, 2012 Oct. PMID 22922362, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (4) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC115777

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular sequestering activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of catalytic activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of nitric-oxide synthase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of nitric oxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    nitric oxide synthase-interacting protein
    Names
    E3 ubiquitin-protein ligase NOSIP
    RING-type E3 ubiquitin transferase NOSIP
    NP_001157156.1
    NP_079809.1
    XP_017167721.1
    XP_030098752.1
    XP_036009246.1
    XP_036009247.1
    XP_036009248.1
    XP_036009249.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163684.1 → NP_001157156.1  nitric oxide synthase-interacting protein isoform 2

      See identical proteins and their annotated locations for NP_001157156.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. This results in a shorter protein (isoform 2) compared to isoform 1.
      Source sequence(s)
      AC126256, AK007962, DV648837
      Consensus CDS
      CCDS52242.1
      UniProtKB/Swiss-Prot
      Q9D6T0
      Related
      ENSMUSP00000103460.3, ENSMUST00000107829.9
      Conserved Domains (2) summary
      pfam15906
      Location:4 → 78
      zf-NOSIP; Zinc-finger of nitric oxide synthase-interacting protein
      cd16662
      Location:195 → 259
      RING-Ubox2_NOSIP; U-box domain 2, a modified RING finger, found in nitric oxide synthase-interacting protein (NOSIP) and similar proteins

    2. NM_025533.3 → NP_079809.1  nitric oxide synthase-interacting protein isoform 1

      See identical proteins and their annotated locations for NP_079809.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC126256, BC089029, DV648837
      Consensus CDS
      CCDS21228.1
      UniProtKB/Swiss-Prot
      Q9D6T0, Q9D8J9
      Related
      ENSMUSP00000003513.4, ENSMUST00000003513.11
      Conserved Domains (2) summary
      pfam15906
      Location:4 → 78
      zf-NOSIP; Zinc-finger of nitric oxide synthase-interacting protein
      cd16662
      Location:220 → 284
      RING-Ubox2_NOSIP; U-box domain 2, a modified RING finger, found in nitric oxide synthase-interacting protein (NOSIP) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      44711840..44727927
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153353.1 → XP_036009246.1  nitric oxide synthase-interacting protein isoform X2

      Conserved Domains (2) summary
      pfam15906
      Location:4 → 78
      zf-NOSIP; Zinc-finger of nitric oxide synthase-interacting protein
      cd16662
      Location:218 → 282
      RING-Ubox2_NOSIP; U-box domain 2, a modified RING finger, found in nitric oxide synthase-interacting protein (NOSIP) and similar proteins

    2. XM_017312232.2 → XP_017167721.1  nitric oxide synthase-interacting protein isoform X1

      UniProtKB/Swiss-Prot
      Q9D6T0, Q9D8J9
      Conserved Domains (2) summary
      pfam15906
      Location:4 → 78
      zf-NOSIP; Zinc-finger of nitric oxide synthase-interacting protein
      cd16662
      Location:220 → 284
      RING-Ubox2_NOSIP; U-box domain 2, a modified RING finger, found in nitric oxide synthase-interacting protein (NOSIP) and similar proteins

    3. XM_030242892.1 → XP_030098752.1  nitric oxide synthase-interacting protein isoform X3

      Conserved Domains (2) summary
      pfam15906
      Location:4 → 78
      zf-NOSIP; Zinc-finger of nitric oxide synthase-interacting protein
      cd16662
      Location:195 → 259
      RING-Ubox2_NOSIP; U-box domain 2, a modified RING finger, found in nitric oxide synthase-interacting protein (NOSIP) and similar proteins

    4. XM_036153355.1 → XP_036009248.1  nitric oxide synthase-interacting protein isoform X4

      Conserved Domains (2) summary
      pfam15906
      Location:4 → 78
      zf-NOSIP; Zinc-finger of nitric oxide synthase-interacting protein
      cd16662
      Location:193 → 257
      RING-Ubox2_NOSIP; U-box domain 2, a modified RING finger, found in nitric oxide synthase-interacting protein (NOSIP) and similar proteins

    5. XM_036153354.1 → XP_036009247.1  nitric oxide synthase-interacting protein isoform X2

      Conserved Domains (2) summary
      pfam15906
      Location:4 → 78
      zf-NOSIP; Zinc-finger of nitric oxide synthase-interacting protein
      cd16662
      Location:218 → 282
      RING-Ubox2_NOSIP; U-box domain 2, a modified RING finger, found in nitric oxide synthase-interacting protein (NOSIP) and similar proteins

    6. XM_036153356.1 → XP_036009249.1  nitric oxide synthase-interacting protein isoform X4

      Conserved Domains (2) summary
      pfam15906
      Location:4 → 78
      zf-NOSIP; Zinc-finger of nitric oxide synthase-interacting protein
      cd16662
      Location:193 → 257
      RING-Ubox2_NOSIP; U-box domain 2, a modified RING finger, found in nitric oxide synthase-interacting protein (NOSIP) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D6T0.1 GenPept UniProtKB/Swiss-Prot:Q9D6T0

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