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    Pole2 polymerase (DNA directed), epsilon 2 (p59 subunit) [ Mus musculus (house mouse) ]

    Gene ID: 18974, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Pole2provided by MGI
    Official Full Name
    polymerase (DNA directed), epsilon 2 (p59 subunit)provided by MGI
    Primary source
    MGI:MGI:1197514
    See related
    Ensembl:ENSMUSG00000020974 AllianceGenome:MGI:1197514
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable DNA binding activity. Predicted to be involved in DNA-dependent DNA replication and error-prone translesion synthesis. Predicted to act upstream of or within DNA replication. Predicted to be located in nuclear body. Predicted to be part of epsilon DNA polymerase complex. Is expressed in several structures, including limb mesenchyme; musculature; nervous system; respiratory system; and tongue. Orthologous to human POLE2 (DNA polymerase epsilon 2, accessory subunit). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in liver E14 (RPKM 11.5), liver E14.5 (RPKM 10.1) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    12 C2; 12 28.73 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (69248547..69274979, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (69201773..69228205, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9330151L19 gene Neighboring gene mannoside acetylglucosaminyltransferase 2 Neighboring gene dynein, axonemal assembly factor 2 Neighboring gene STARR-seq mESC enhancer starr_32361 Neighboring gene STARR-positive B cell enhancer ABC_E10753 Neighboring gene kelch domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_32363 Neighboring gene kelch domain containing 2 Neighboring gene nuclear export mediator factor Neighboring gene STARR-seq mESC enhancer starr_32364 Neighboring gene STARR-positive B cell enhancer ABC_E10754

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The small subunits of human and mouse DNA polymerase epsilon are homologous to the second largest subunit of the yeast Saccharomyces cerevisiae DNA polymerase epsilon. Jokela M, et al. Nucleic Acids Res, 1998 Feb 1. PMID 9443964, Free PMC Article
    2. The second largest subunit of mouse DNA polymerase epsilon, DPE2, interacts with SAP18 and recruits the Sin3 co-repressor protein to DNA. Wada M, et al. J Biochem, 2002 Mar. PMID 11872158
    3. Polε Instability Drives Replication Stress, Abnormal Development, and Tumorigenesis. Bellelli R, et al. Mol Cell, 2018 May 17. PMID 29754823, Free PMC Article
    4. Role of FEN1 S187 phosphorylation in counteracting oxygen-induced stress and regulating postnatal heart development. Zhou L, et al. FASEB J, 2017 Jan. PMID 27694478, Free PMC Article
    5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The second largest subunit of mouse DNA polymerase epsilon was found to interact with SAP18. The interaction induced repression of transcription.
      Title: The second largest subunit of mouse DNA polymerase epsilon, DPE2, interacts with SAP18 and recruits the Sin3 co-repressor protein to DNA.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA-templated DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA-templated DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in error-prone translesion synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of epsilon DNA polymerase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of epsilon DNA polymerase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA polymerase epsilon subunit 2
    Names
    DNA polymerase II subunit 2
    DNA polymerase epsilon small subunit
    DNA polymerase epsilon subunit B
    NP_035263.1
    XP_006515661.1
    XP_006515662.1
    XP_011242320.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011133.2 → NP_035263.1  DNA polymerase epsilon subunit 2

      See identical proteins and their annotated locations for NP_035263.1

      Status: PROVISIONAL

      Source sequence(s)
      AF036898, AK077592
      Consensus CDS
      CCDS36463.1
      UniProtKB/Swiss-Prot
      O54956, Q6P3Y7, Q8BP72
      UniProtKB/TrEMBL
      Q3TA87
      Related
      ENSMUSP00000021359.6, ENSMUST00000021359.7
      Conserved Domains (2) summary
      pfam04042
      Location:288 → 489
      DNA_pol_E_B; DNA polymerase alpha/epsilon subunit B
      pfam12213
      Location:3 → 73
      Dpoe2NT; DNA polymerases epsilon N terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      69248547..69274979 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011244018.2 → XP_011242320.1  DNA polymerase epsilon subunit 2 isoform X1

      UniProtKB/TrEMBL
      Q3TA87
      Conserved Domains (1) summary
      pfam04042
      Location:228 → 429
      DNA_pol_E_B; DNA polymerase alpha/epsilon subunit B

    2. XM_006515599.1 → XP_006515662.1  DNA polymerase epsilon subunit 2 isoform X3

      Conserved Domains (1) summary
      pfam04042
      Location:40 → 241
      DNA_pol_E_B; DNA polymerase alpha/epsilon subunit B

    3. XM_006515598.4 → XP_006515661.1  DNA polymerase epsilon subunit 2 isoform X2

      UniProtKB/TrEMBL
      A0A1Y7VN66
      Conserved Domains (2) summary
      pfam12213
      Location:4 → 74
      Dpoe2NT; DNA polymerases epsilon N terminal
      cl13995
      Location:288 → 404
      MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O54956.2 GenPept UniProtKB/Swiss-Prot:O54956

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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