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    Obi1 ORC ubiquitin ligase 1 [ Mus musculus (house mouse) ]

    Gene ID: 72486, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Obi1provided by MGI
    Official Full Name
    ORC ubiquitin ligase 1provided by MGI
    Primary source
    MGI:MGI:1919736
    See related
    Ensembl:ENSMUSG00000022120 AllianceGenome:MGI:1919736
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Obl1; Rnf219; 2610206B13Rik; 2810449K13Rik
    Summary
    Predicted to enable chromatin binding activity and ubiquitin-protein transferase activity. Acts upstream of or within positive regulation of mRNA splicing, via spliceosome. Predicted to be located in chromatin. Orthologous to human OBI1 (ORC ubiquitin ligase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E11.5 (RPKM 5.7), limb E14.5 (RPKM 3.7) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    14 E2.3; 14 54.24 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (104714970..104760148, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (104477534..104522712, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA D130079A08 gene Neighboring gene predicted gene, 35362 Neighboring gene POU domain, class 4, transcription factor 1 Neighboring gene predicted gene, 22021 Neighboring gene predicted gene, 35680

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. RNF219 interacts with CCR4-NOT in regulating stem cell differentiation. Du H, et al. J Mol Cell Biol, 2020 Oct 26. PMID 33104214, Free PMC Article
    2. Ring finger protein 219 regulates inflammatory responses by stabilizing sirtuin 1. Hwang JS, et al. Br J Pharmacol, 2020 Oct. PMID 32220064, Free PMC Article
    3. Functional and comparative genomic analysis of the piebald deletion region of mouse chromosome 14. Peterson KA, et al. Genomics, 2002 Aug. PMID 12160731
    4. In vivo dual-tagging proteomic approach in studying signaling pathways in immune response. Wang T, et al. J Proteome Res, 2005 May-Jun. PMID 15952741
    5. A broadly applicable high-throughput screening strategy identifies new regulators of Dlg4 (Psd-95) alternative splicing. Zheng S, et al. Genome Res, 2013 Jun. PMID 23636947, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RNF219 interacts with CCR4-NOT in regulating stem cell differentiation.
      Title: RNF219 interacts with CCR4-NOT in regulating stem cell differentiation.
    2. Ring finger protein 219 regulates inflammatory responses by stabilizing sirtuin 1.
      Title: Ring finger protein 219 regulates inflammatory responses by stabilizing sirtuin 1.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC35679

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein autoubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein monoubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ORC ubiquitin ligase 1
    Names
    ring finger protein 219
    NP_080323.3
    XP_011243508.1
    XP_036014750.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026047.4 → NP_080323.3  ORC ubiquitin ligase 1

      See identical proteins and their annotated locations for NP_080323.3

      Status: VALIDATED

      Source sequence(s)
      AC121997, BI986775, CN697474
      Consensus CDS
      CCDS27320.1
      UniProtKB/Swiss-Prot
      Q8K2Y0, Q9CYU1, Q9D1Y0
      UniProtKB/TrEMBL
      G3X8V5
      Related
      ENSMUSP00000022716.3, ENSMUST00000022716.4
      Conserved Domains (3) summary
      PHA03307
      Location:269 → 370
      PHA03307; transcriptional regulator ICP4; Provisional
      TIGR02168
      Location:90 → 307
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd16562
      Location:15 → 56
      RING-HC_RNF219; RING finger, HC subclass, found in RING finger protein 219 (RNF219) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      104714970..104760148 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158857.1 → XP_036014750.1  ORC ubiquitin ligase 1 isoform X1

    2. XM_011245206.3 → XP_011243508.1  ORC ubiquitin ligase 1 isoform X2

      See identical proteins and their annotated locations for XP_011243508.1

      UniProtKB/TrEMBL
      A0A2I3BRT6
      Related
      ENSMUSP00000154655.2, ENSMUST00000228448.2
      Conserved Domains (2) summary
      COG5432
      Location:18 → 165
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
      cd16562
      Location:15 → 56
      RING-HC_RNF219; RING finger, HC subclass, found in RING finger protein 219 (RNF219) and similar proteins

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_028253.1: Suppressed sequence

      Description
      NM_028253.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K2Y0.2 GenPept UniProtKB/Swiss-Prot:Q8K2Y0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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