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    Dock8 dedicator of cytokinesis 8 [ Mus musculus (house mouse) ]

    Gene ID: 76088, updated on 28-Aug-2021

    Summary

    Official Symbol
    Dock8provided by MGI
    Official Full Name
    dedicator of cytokinesis 8provided by MGI
    Primary source
    MGI:MGI:1921396
    See related
    Ensembl:ENSMUSG00000052085
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI461977; 1200017A24Rik; 5830472H07Rik; A130095G14Rik
    Expression
    Broad expression in thymus adult (RPKM 25.8), spleen adult (RPKM 17.9) and 18 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Dock8 in Genome Data Viewer
    Location:
    19; 19 B
    Exon count:
    52
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (24976753..25179796)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (24999321..25202432)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (25074019..25276922)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene forkhead box D4 Neighboring gene microRNA 3084-1 Neighboring gene COBW domain containing 1 Neighboring gene NADH:ubiquinone oxidoreductase subunit B4B Neighboring gene predicted gene, 34235 Neighboring gene predicted gene, 34186 Neighboring gene predicted gene, 24252 Neighboring gene KN motif and ankyrin repeat domains 1 Neighboring gene predicted gene, 34432 Neighboring gene predicted gene, 52392

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell leading edge IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in leading edge membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    dedicator of cytokinesis protein 8

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028785.3NP_083061.2  dedicator of cytokinesis protein 8

      See identical proteins and their annotated locations for NP_083061.2

      Status: VALIDATED

      Source sequence(s)
      AK028968, AK038285, AK050543, AK131180, DT909592
      Consensus CDS
      CCDS37943.1
      UniProtKB/Swiss-Prot
      Q8C147
      Related
      ENSMUSP00000025831.7, ENSMUST00000025831.8
      Conserved Domains (3) summary
      cd08696
      Location:560740
      C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11701
      Location:16372058
      DHR2_DOCK8; Dock Homology Region 2, a GEF domain, of Class C Dedicator of Cytokinesis 8
      pfam11878
      Location:73164
      DUF3398; Domain of unknown function (DUF3398)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      24976753..25179796
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527436.5XP_006527499.1  dedicator of cytokinesis protein 8 isoform X2

      Conserved Domains (2) summary
      cd08696
      Location:560740
      C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      pfam11878
      Location:56166
      DUF3398; Domain of unknown function (DUF3398)
    2. XM_011247397.4XP_011245699.1  dedicator of cytokinesis protein 8 isoform X1

      See identical proteins and their annotated locations for XP_011245699.1

      Conserved Domains (3) summary
      cd08696
      Location:492672
      C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11701
      Location:15691990
      DHR2_DOCK8; Dock Homology Region 2, a GEF domain, of Class C Dedicator of Cytokinesis 8
      pfam11878
      Location:198
      DUF3398; Domain of unknown function (DUF3398)
    3. XM_006527435.3XP_006527498.1  dedicator of cytokinesis protein 8 isoform X1

      See identical proteins and their annotated locations for XP_006527498.1

      Conserved Domains (3) summary
      cd08696
      Location:492672
      C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11701
      Location:15691990
      DHR2_DOCK8; Dock Homology Region 2, a GEF domain, of Class C Dedicator of Cytokinesis 8
      pfam11878
      Location:198
      DUF3398; Domain of unknown function (DUF3398)

    RNA

    1. XR_004940182.1 RNA Sequence

    2. XR_004940183.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_175233.3: Suppressed sequence

      Description
      NM_175233.3: This RefSeq was temporarily suppressed because currently there are not sufficient data to support this transcript.
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