Dcstamp dendrocyte expressed seven transmembrane protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dcstampprovided by MGI
Official Full Name: dendrocyte expressed seven transmembrane proteinprovided by MGI
Primary source: MGI:MGI:1923016
See related: Ensembl:ENSMUSG00000022303 AllianceGenome:MGI:1923016
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: FIND; Tm7sf4; DC-STAMP; mDC-STAMP; 4833414I07Rik
Summary: Involved in several processes, including cellular response to cytokine stimulus; myeloid leukocyte differentiation; and positive regulation of bone resorption. Located in cell surface; endoplasmic reticulum membrane; and endosome membrane. Orthologous to human DCSTAMP (dendrocyte expressed seven transmembrane protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 15 B3.1; 15 15.51 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (39609326..39624334)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (39745930..39760938)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hypoxia-induced factor 1alpha promotes osteotomy-induced regional acceleratory phenomenon via DC-STAMP mediated membrane fusion.
Title: Hypoxia-induced factor 1α promotes osteotomy-induced regional acceleratory phenomenon via DC-STAMP mediated membrane fusion.
Connective tissue growth factor (CTGF) regulates the fusion of osteoclast precursors by inhibiting Bcl6 in periodontitis.
Title: Connective tissue growth factor (CTGF) regulates the fusion of osteoclast precursors by inhibiting Bcl6 in periodontitis.
Multinuclear macrophages of BCG-infected mice express CD antigens and DC-STAMP in the process of fusion.
Title: In Vitro Analysis of the Expression of CD11, CD29, CD36, and DC-STAMP Molecules during the Formation of Multinuclear Macrophages in BCG-Infected Mice.
These results suggested that hyperphosphatemia in the patients with CKD suppresses bone resorption by inhibiting osteoclastogenesis, and this impairs the regulation of bone metabolism.
Title: Inorganic phosphate-induced impairment of osteoclast cell-cell fusion by the inhibition of AP-1-mediated DC-STAMP expression.
Immunoreceptor tyrosine-based inhibitory motif DC-STAMP is a functional motif that regulates osteoclast differentiation through the NFATc1/Ca(2+) axis.
Title: Dendritic Cell-Specific Transmembrane Protein (DC-STAMP) Regulates Osteoclast Differentiation via the Ca(2+) /NFATc1 Axis.
These results suggest that Luman regulates the multinucleation of osteoclasts by promoting cell fusion of mononuclear osteoclasts through DC-STAMP induction and intracellular distribution during osteoclastogenesis.
Title: Luman is involved in osteoclastogenesis through the regulation of DC-STAMP expression, stability and localization.
miR-7b inhibits osteoclastogenesis and cell-cell fusion by directly targeting DC-STAMP.
Title: MiR-7b directly targets DC-STAMP causing suppression of NFATc1 and c-Fos signaling during osteoclast fusion and differentiation.
our data indicate that Pin1 is a determinant of bone mass through the regulation of the osteoclast fusion protein DC-STAMP
Title: Pin1 regulates osteoclast fusion through suppression of the master regulator of cell fusion DC-STAMP.
Mechanical vibration of osteoclast precursor cells reduces DC-STAMP expression in osteoclast precursor cells.
Title: Mechanical vibration inhibits osteoclast formation by reducing DC-STAMP receptor expression in osteoclast precursor cells.
DC-STAMP, Siglec-15, Tspan7 and Mst1r expression was downregulated by docosahexaenoic acid, but not eicosapentaenoic acid during osteoclastogenesis in vitro.
Title: Impact of docosahexaenoic acid on gene expression during osteoclastogenesis in vitro--a comprehensive analysis.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to interleukin-4	ISO Inferred from Sequence Orthology more info
involved_in cellular response to macrophage colony-stimulating factor stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to tumor necrosis factor	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
involved_in membrane fusion	IDA Inferred from Direct Assay more info	PubMed
involved_in membrane fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in myeloid dendritic cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell growth	IDA Inferred from Direct Assay more info	PubMed
involved_in osteoclast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within osteoclast fusion	IDA Inferred from Direct Assay more info	PubMed
involved_in osteoclast fusion	IDA Inferred from Direct Assay more info	PubMed
involved_in osteoclast fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of bone resorption	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of macrophage fusion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of macrophage fusion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of macrophage fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of monocyte differentiation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in endosome membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: dendritic cell-specific transmembrane protein

Names: dentrocyte expressed seven transmembrane protein; transmembrane 7 superfamily member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001289506.1 → NP_001276435.1 dendritic cell-specific transmembrane protein isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses ans alternate splice site compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AC158776

UniProtKB/TrEMBL

B7ZP05

Conserved Domains (1) summary

pfam07782
Location:242 → 420

DC_STAMP; DC-STAMP-like protein
NM_001289508.1 → NP_001276437.1 dendritic cell-specific transmembrane protein isoform 3

See identical proteins and their annotated locations for NP_001276437.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate splice site compared to variant 1. The encoded isoform (3) is shorter than isoform 1.

Source sequence(s)

AB109561, AC158776

Consensus CDS

CCDS88758.1

UniProtKB/TrEMBL

B7ZP05

Related

ENSMUSP00000154397.2, ENSMUST00000227368.2

Conserved Domains (1) summary

pfam07782
Location:242 → 365

DC_STAMP; DC-STAMP-like protein
NM_001289512.1 → NP_001276441.1 dendritic cell-specific transmembrane protein isoform 4

See identical proteins and their annotated locations for NP_001276441.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks an in-frame exon in the 3' coding region compared to variant 1. The encoded isoform (4) is shorter than isoform 1.

Source sequence(s)

AC158776, AK014697

Consensus CDS

CCDS88759.1

UniProtKB/Swiss-Prot

Q7TNJ0

Related

ENSMUSP00000154362.2, ENSMUST00000228556.2

Conserved Domains (1) summary

pfam07782
Location:242 → 356

DC_STAMP; DC-STAMP-like protein
NM_001289513.1 → NP_001276442.1 dendritic cell-specific transmembrane protein isoform 5

Status: VALIDATED

Description

Transcript Variant: This variant (5) uses two alternate splice sites in the coding region, one of which results in a frame shift compared to variant 1. The encoded isoform (5) is shorter and has a distinct C-terminus compared to isoform 1.

Source sequence(s)

AC158776

Consensus CDS

CCDS88757.1

UniProtKB/TrEMBL

A0A2I3BPX1, B7ZP05

Related

ENSMUSP00000153957.2, ENSMUST00000227792.2

Conserved Domains (1) summary

pfam07782
Location:242 → 365

DC_STAMP; DC-STAMP-like protein
NM_029422.4 → NP_083698.1 dendritic cell-specific transmembrane protein isoform 1

See identical proteins and their annotated locations for NP_083698.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC158776, AY517483

Consensus CDS

CCDS27444.1

UniProtKB/Swiss-Prot

B2RT61, Q6R315, Q7TNI9, Q7TNJ0, Q9D619

UniProtKB/TrEMBL

Q3U482

Related

ENSMUSP00000022913.5, ENSMUST00000022913.6

Conserved Domains (1) summary

pfam07782
Location:242 → 421

DC_STAMP; DC-STAMP-like protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

39609326..39624334

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006521519.3 → XP_006521582.1 dendritic cell-specific transmembrane protein isoform X1

Conserved Domains (1) summary

pfam07782
Location:57 → 236

DC_STAMP; DC-STAMP-like protein