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    Ttll13 tubulin tyrosine ligase-like family, member 13 [ Mus musculus (house mouse) ]

    Gene ID: 269954, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Ttll13provided by MGI
    Official Full Name
    tubulin tyrosine ligase-like family, member 13provided by MGI
    Primary source
    MGI:MGI:1920845
    See related
    Ensembl:ENSMUSG00000045467 AllianceGenome:MGI:1920845
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4921538O11; 1700111A04Rik
    Summary
    Predicted to enable tubulin binding activity and tubulin-glutamic acid ligase activity. Predicted to be involved in microtubule cytoskeleton organization and protein polyglutamylation. Predicted to be located in microtubule. Predicted to be active in cilium. Orthologous to human TTLL13 (tubulin tyrosine ligase like 13). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward testis adult (RPKM 120.2) See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 D2; 7 45.57 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (79896101..79910569)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (80246353..80260821)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10446 Neighboring gene calcium and integrin binding 1 Neighboring gene GDP-D-glucose phosphorylase 1 Neighboring gene STARR-positive B cell enhancer ABC_E4940 Neighboring gene neugrin, neurite outgrowth associated Neighboring gene STARR-positive B cell enhancer ABC_E2826 Neighboring gene vacuolar protein sorting 33B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A targeted multienzyme mechanism for selective microtubule polyglutamylation. van Dijk J, et al. Mol Cell, 2007 May 11. PMID 17499049
    2. Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice. Ye B, et al. Nat Commun, 2018 Mar 28. PMID 29593216, Free PMC Article
    3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (2) 
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tubulin-glutamic acid ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tubulin-glutamic acid ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein modification process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein polyglutamylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tubulin polyglutamylase TTLL13
    Names
    tubulin--tyrosine ligase-like protein 13

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001396015.1 → NP_001382944.1  tubulin polyglutamylase TTLL13 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC109232
      UniProtKB/TrEMBL
      A6H647
      Related
      ENSMUSP00000145702.2, ENSMUST00000205270.2
      Conserved Domains (1) summary
      pfam03133
      Location:133 → 418
      TTL; Tubulin-tyrosine ligase family

    2. NM_177765.4 → NP_808433.2  tubulin polyglutamylase TTLL13 isoform 2

      See identical proteins and their annotated locations for NP_808433.2

      Status: VALIDATED

      Source sequence(s)
      AC109232
      Consensus CDS
      CCDS39996.1
      UniProtKB/Swiss-Prot
      A4Q9F6, Q8C0W9
      UniProtKB/TrEMBL
      A6H647
      Related
      ENSMUSP00000062795.7, ENSMUST00000058266.9
      Conserved Domains (1) summary
      pfam03133
      Location:133 → 418
      TTL; Tubulin-tyrosine ligase family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      79896101..79910569
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540925.4 → XP_006540988.2  tubulin polyglutamylase TTLL13 isoform X7

      UniProtKB/TrEMBL
      A6H647
      Conserved Domains (2) summary
      TIGR03185
      Location:383 → 552
      DNA_S_dndD; DNA sulfur modification protein DndD
      pfam03133
      Location:71 → 356
      TTL; Tubulin-tyrosine ligase family

    2. XM_030242619.1 → XP_030098479.1  tubulin polyglutamylase TTLL13 isoform X7

      UniProtKB/TrEMBL
      A6H647
      Conserved Domains (2) summary
      TIGR03185
      Location:383 → 552
      DNA_S_dndD; DNA sulfur modification protein DndD
      pfam03133
      Location:71 → 356
      TTL; Tubulin-tyrosine ligase family

    3. XM_030242621.2 → XP_030098481.1  tubulin polyglutamylase TTLL13 isoform X11

      UniProtKB/TrEMBL
      A6H647
      Conserved Domains (2) summary
      TIGR03185
      Location:340 → 509
      DNA_S_dndD; DNA sulfur modification protein DndD
      pfam03133
      Location:28 → 313
      TTL; Tubulin-tyrosine ligase family

    4. XM_006540914.5 → XP_006540977.1  tubulin polyglutamylase TTLL13 isoform X1

      See identical proteins and their annotated locations for XP_006540977.1

      UniProtKB/TrEMBL
      A6H647
      Conserved Domains (2) summary
      TIGR03185
      Location:466 → 635
      DNA_S_dndD; DNA sulfur modification protein DndD
      pfam03133
      Location:154 → 439
      TTL; Tubulin-tyrosine ligase family

    5. XM_006540915.5 → XP_006540978.1  tubulin polyglutamylase TTLL13 isoform X1

      See identical proteins and their annotated locations for XP_006540978.1

      UniProtKB/TrEMBL
      A6H647
      Conserved Domains (2) summary
      TIGR03185
      Location:466 → 635
      DNA_S_dndD; DNA sulfur modification protein DndD
      pfam03133
      Location:154 → 439
      TTL; Tubulin-tyrosine ligase family

    6. XM_006540913.5 → XP_006540976.1  tubulin polyglutamylase TTLL13 isoform X1

      See identical proteins and their annotated locations for XP_006540976.1

      UniProtKB/TrEMBL
      A6H647
      Conserved Domains (2) summary
      TIGR03185
      Location:466 → 635
      DNA_S_dndD; DNA sulfur modification protein DndD
      pfam03133
      Location:154 → 439
      TTL; Tubulin-tyrosine ligase family

    7. XM_006540918.5 → XP_006540981.1  tubulin polyglutamylase TTLL13 isoform X4

      UniProtKB/TrEMBL
      A6H647
      Conserved Domains (2) summary
      TIGR03185
      Location:466 → 635
      DNA_S_dndD; DNA sulfur modification protein DndD
      pfam03133
      Location:154 → 439
      TTL; Tubulin-tyrosine ligase family

    8. XM_006540920.5 → XP_006540983.1  tubulin polyglutamylase TTLL13 isoform X8

      See identical proteins and their annotated locations for XP_006540983.1

      Conserved Domains (2) summary
      TIGR03185
      Location:466 → 635
      DNA_S_dndD; DNA sulfur modification protein DndD
      pfam03133
      Location:154 → 439
      TTL; Tubulin-tyrosine ligase family

    9. XM_006540921.5 → XP_006540984.1  tubulin polyglutamylase TTLL13 isoform X8

      See identical proteins and their annotated locations for XP_006540984.1

      Conserved Domains (2) summary
      TIGR03185
      Location:466 → 635
      DNA_S_dndD; DNA sulfur modification protein DndD
      pfam03133
      Location:154 → 439
      TTL; Tubulin-tyrosine ligase family

    10. XM_006540916.5 → XP_006540979.1  tubulin polyglutamylase TTLL13 isoform X2

      UniProtKB/TrEMBL
      A6H647
      Conserved Domains (2) summary
      TIGR03185
      Location:466 → 632
      DNA_S_dndD; DNA sulfur modification protein DndD
      pfam03133
      Location:154 → 439
      TTL; Tubulin-tyrosine ligase family

    11. XM_036153142.1 → XP_036009035.1  tubulin polyglutamylase TTLL13 isoform X6

      UniProtKB/TrEMBL
      A6H647
      Conserved Domains (1) summary
      pfam03133
      Location:154 → 439
      TTL; Tubulin-tyrosine ligase family

    12. XM_030242620.2 → XP_030098480.1  tubulin polyglutamylase TTLL13 isoform X9

      Conserved Domains (2) summary
      TIGR03185
      Location:466 → 632
      DNA_S_dndD; DNA sulfur modification protein DndD
      pfam03133
      Location:154 → 439
      TTL; Tubulin-tyrosine ligase family

    13. XM_006540917.5 → XP_006540980.1  tubulin polyglutamylase TTLL13 isoform X3

      UniProtKB/TrEMBL
      A6H647
      Conserved Domains (2) summary
      TIGR03185
      Location:445 → 614
      DNA_S_dndD; DNA sulfur modification protein DndD
      pfam03133
      Location:133 → 418
      TTL; Tubulin-tyrosine ligase family

    14. XM_006540922.5 → XP_006540985.1  tubulin polyglutamylase TTLL13 isoform X10

      UniProtKB/TrEMBL
      A6H647
      Conserved Domains (2) summary
      TIGR03185
      Location:361 → 530
      DNA_S_dndD; DNA sulfur modification protein DndD
      pfam03133
      Location:49 → 334
      TTL; Tubulin-tyrosine ligase family

    15. XM_017322293.3 → XP_017177782.1  tubulin polyglutamylase TTLL13 isoform X11

      UniProtKB/TrEMBL
      A6H647
      Conserved Domains (2) summary
      TIGR03185
      Location:340 → 509
      DNA_S_dndD; DNA sulfur modification protein DndD
      pfam03133
      Location:28 → 313
      TTL; Tubulin-tyrosine ligase family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A4Q9F6.1 GenPept UniProtKB/Swiss-Prot:A4Q9F6

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