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    Depp1 DEPP1 autophagy regulator [ Mus musculus (house mouse) ]

    Gene ID: 213393, updated on 2-Apr-2024

    Summary

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    Official Symbol
    Depp1provided by MGI
    Official Full Name
    DEPP1 autophagy regulatorprovided by MGI
    Primary source
    MGI:MGI:1918730
    See related
    Ensembl:ENSMUSG00000048489 AllianceGenome:MGI:1918730
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Depp; Fseg; 8430408G22Rik
    Summary
    Predicted to be involved in regulation of autophagy. Predicted to act upstream of or within autophagy. Located in mitochondrion. Is expressed in endothelium of renal artery and metanephros. Orthologous to human DEPP1 (DEPP1 autophagy regulator). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in liver adult (RPKM 61.7), liver E18 (RPKM 58.4) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    6 E3; 6 53.83 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (116627645..116629808)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (116650684..116652847)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 422 Neighboring gene STARR-seq mESC enhancer starr_17106 Neighboring gene Ras association (RalGDS/AF-6) domain family member 4 Neighboring gene STARR-positive B cell enhancer ABC_E6474 Neighboring gene microRNA 7043 Neighboring gene STARR-positive B cell enhancer ABC_E2202 Neighboring gene STARR-positive B cell enhancer mm9_chr6:116632394-116632695 Neighboring gene transmembrane protein 72 Neighboring gene predicted gene, 22882

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. DEPP Deficiency Contributes to Browning of White Adipose Tissue. Guo F, et al. Int J Mol Sci, 2022 Jun 12. PMID 35743009, Free PMC Article
    2. DEPP/DEPP1/C10ORF10 regulates hepatic glucose and fat metabolism partly via ROS-induced FGF21. Li W, et al. FASEB J, 2018 Oct. PMID 29702025
    3. Insulin-mediated regulation of decidual protein induced by progesterone (DEPP) in adipose tissue and liver. Kuroda Y, et al. Horm Metab Res, 2010 Mar. PMID 19937567
    4. Accelerated coronary angiogenesis by vegfr1-knockout endocardial cells. Zhang Z, et al. PLoS One, 2013. PMID 23894673, Free PMC Article
    5. Isolation of arterial-specific genes by subtractive hybridization reveals molecular heterogeneity among arterial endothelial cells. Shin D, et al. Dev Dyn, 2005 Aug. PMID 15977181

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Clone Names

    • MGC6835

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein DEPP1
    Names
    decidual protein induced by progesterone
    fat-specific expressed
    fat-specific-expressed gene protein
    protein DEPP

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166580.1 → NP_001160052.1  protein DEPP1

      See identical proteins and their annotated locations for NP_001160052.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC160973, BC058515
      Consensus CDS
      CCDS51882.1
      UniProtKB/Swiss-Prot
      Q8BU66, Q8K2F3
      Related
      ENSMUSP00000136165.2, ENSMUST00000178241.4
      Conserved Domains (1) summary
      pfam15343
      Location:25 → 205
      DEPP; Decidual protein induced by progesterone family

    2. NM_145980.2 → NP_666092.1  protein DEPP1

      See identical proteins and their annotated locations for NP_666092.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript.
      Source sequence(s)
      AK078806, AK087284, BB683812
      Consensus CDS
      CCDS51882.1
      UniProtKB/Swiss-Prot
      Q8BU66, Q8K2F3
      Related
      ENSMUSP00000070203.6, ENSMUST00000067354.10
      Conserved Domains (1) summary
      pfam15343
      Location:25 → 205
      DEPP; Decidual protein induced by progesterone family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      116627645..116629808
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K2F3.1 GenPept UniProtKB/Swiss-Prot:Q8K2F3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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