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    Otud4 OTU domain containing 4 [ Mus musculus (house mouse) ]

    Gene ID: 73945, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Otud4provided by MGI
    Official Full Name
    OTU domain containing 4provided by MGI
    Primary source
    MGI:MGI:1098801
    See related
    Ensembl:ENSMUSG00000036990 AllianceGenome:MGI:1098801
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D8Ertd69e; mKIAA1046; 4930431L18Rik
    Summary
    Enables Lys63-specific deubiquitinase activity. Involved in negative regulation of interleukin-1-mediated signaling pathway; negative regulation of toll-like receptor signaling pathway; and protein K63-linked deubiquitination. Predicted to be located in cytosol. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and immune system. Orthologous to human OTUD4 (OTU deubiquitinase 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 14.9), placenta adult (RPKM 12.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Otud4 in Genome Data Viewer
    Location:
    8 C1; 8 37.74 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (80366305..80404384)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (79639676..79677755)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene 5'-nucleotidase, cytosolic II pseudogene Neighboring gene STARR-seq mESC enhancer starr_22009 Neighboring gene STARR-seq mESC enhancer starr_22010 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E3787 Neighboring gene predicted gene, 51579 Neighboring gene tumor protein D52, pseudogene Neighboring gene ATP-binding cassette, sub-family E member 1 Neighboring gene STARR-positive B cell enhancer ABC_E9318 Neighboring gene anaphase promoting complex subunit 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Upregulation of glycolytic enzyme PFKFB3 by deubiquitinase OTUD4 promotes cardiac fibrosis post myocardial infarction. Wang F, et al. J Mol Med (Berl), 2023 Jun. PMID 37162556, Free PMC Article
    2. OTUD4 alleviates hepatic ischemia-reperfusion injury by suppressing the K63-linked ubiquitination of TRAF6. Liu H, et al. Biochem Biophys Res Commun, 2020 Mar 19. PMID 31964525
    3. Ubiquitination and deubiquitination of 4E-T regulate neural progenitor cell maintenance and neurogenesis by controlling P-body formation. Kedia S, et al. Cell Rep, 2022 Jul 12. PMID 35830814
    4. OTUD4 Is a Phospho-Activated K63 Deubiquitinase that Regulates MyD88-Dependent Signaling. Zhao Y, et al. Mol Cell, 2018 Feb 1. PMID 29395066, Free PMC Article
    5. Loss of the tumor suppressor BAP1 causes myeloid transformation. Dey A, et al. Science, 2012 Sep 21. PMID 22878500, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Upregulation of glycolytic enzyme PFKFB3 by deubiquitinase OTUD4 promotes cardiac fibrosis post myocardial infarction.
      Title: Upregulation of glycolytic enzyme PFKFB3 by deubiquitinase OTUD4 promotes cardiac fibrosis post myocardial infarction.
    2. OTUD4 alleviates hepatic ischemia-reperfusion injury by suppressing the K63-linked ubiquitination of TRAF6.
      Title: OTUD4 alleviates hepatic ischemia-reperfusion injury by suppressing the K63-linked ubiquitination of TRAF6.
    3. The authors show an essential role of OTUD4 in virus-triggered signaling and contribute to the understanding of deubiquitination-mediated regulation of innate antiviral responses.
      Title: Induction of OTUD4 by viral infection promotes antiviral responses through deubiquitinating and stabilizing MAVS.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (5)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables K63-linked deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables K63-linked deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables K63-linked deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA alkylation repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of interleukin-1-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of interleukin-1-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of interleukin-1-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of toll-like receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of toll-like receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of toll-like receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K48-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K63-linked deubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein K63-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of protein K48-linked deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of protein K48-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    OTU domain-containing protein 4
    NP_001074633.1
    NP_001242962.1
    XP_006531469.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081164.1 → NP_001074633.1  OTU domain-containing protein 4 isoform 2

      See identical proteins and their annotated locations for NP_001074633.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC101687
      Consensus CDS
      CCDS57626.1
      UniProtKB/TrEMBL
      A0A0R4J260
      Related
      ENSMUSP00000134097.2, ENSMUST00000173286.8
      Conserved Domains (2) summary
      pfam12293
      Location:557 → 643
      T4BSS_DotH_IcmK; Putative outer membrane core complex of type IVb secretion
      cl19932
      Location:42 → 121
      OTU; OTU-like cysteine protease

    2. NM_001256033.1 → NP_001242962.1  OTU domain-containing protein 4 isoform 1

      See identical proteins and their annotated locations for NP_001242962.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC101687, AW494258, BC138373
      Consensus CDS
      CCDS57625.1
      UniProtKB/Swiss-Prot
      B2RRE7, B7ZNI5, Q80TL3, Q9CUN2
      Related
      ENSMUSP00000133939.2, ENSMUST00000173078.8
      Conserved Domains (2) summary
      pfam12293
      Location:558 → 644
      T4BSS_DotH_IcmK; Putative outer membrane core complex of type IVb secretion
      cl19932
      Location:42 → 121
      OTU; OTU-like cysteine protease

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      80366305..80404384
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531406.5 → XP_006531469.1  OTU domain-containing protein 4 isoform X1

      Conserved Domains (2) summary
      PHA03247
      Location:478 → 807
      PHA03247; large tegument protein UL36; Provisional
      cl19932
      Location:3 → 56
      OTU; OTU-like cysteine protease
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B2RRE7.1 GenPept UniProtKB/Swiss-Prot:B2RRE7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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