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    Krt222 keratin 222 [ Mus musculus (house mouse) ]

    Gene ID: 268481, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Krt222provided by MGI
    Official Full Name
    keratin 222provided by MGI
    Primary source
    MGI:MGI:2442728
    See related
    Ensembl:ENSMUSG00000035849 AllianceGenome:MGI:2442728
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6330509G02Rik
    Summary
    Predicted to enable structural molecule activity. Predicted to be located in intermediate filament. Orthologous to human KRT222 (keratin 222). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in cerebellum adult (RPKM 8.2), cortex adult (RPKM 5.5) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Krt222 in Genome Data Viewer
    Location:
    11 D; 11 62.92 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (99123587..99134973, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (99232761..99244147, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32249 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 Neighboring gene STARR-seq mESC enhancer starr_30702 Neighboring gene STARR-positive B cell enhancer ABC_E8451 Neighboring gene predicted gene, 32385 Neighboring gene keratin 24 Neighboring gene STARR-seq mESC enhancer starr_30703 Neighboring gene keratin 25

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. New consensus nomenclature for mammalian keratins. Schweizer J, et al. J Cell Biol, 2006 Jul 17. PMID 16831889, Free PMC Article
    2. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC100296

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in intermediate filament IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    keratin-like protein KRT222

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001361584.1 → NP_001348513.1  keratin-like protein KRT222 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK044068, BB850745, BC079890
      Consensus CDS
      CCDS88251.1
      Related
      ENSMUSP00000044561.7, ENSMUST00000038214.7
      Conserved Domains (1) summary
      pfam00038
      Location:2 → 109
      Filament; Intermediate filament protein

    2. NM_172946.3 → NP_766534.1  keratin-like protein KRT222 isoform 1

      See identical proteins and their annotated locations for NP_766534.1

      Status: VALIDATED

      Source sequence(s)
      AK031954, BB850745, BC079890
      Consensus CDS
      CCDS25375.1
      UniProtKB/Swiss-Prot
      Q3UU52, Q68FD8, Q8CCX5
      Related
      ENSMUSP00000099421.4, ENSMUST00000103132.10
      Conserved Domains (3) summary
      pfam07889
      Location:21 → 83
      DUF1664; Protein of unknown function (DUF1664)
      cd16269
      Location:118 → 131
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:46 → 146
      GBP_C; Guanylate-binding protein, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      99123587..99134973 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CCX5.1 GenPept UniProtKB/Swiss-Prot:Q8CCX5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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