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    Mtmr9 myotubularin related protein 9 [ Mus musculus (house mouse) ]

    Gene ID: 210376, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Mtmr9provided by MGI
    Official Full Name
    myotubularin related protein 9provided by MGI
    Primary source
    MGI:MGI:2442842
    See related
    Ensembl:ENSMUSG00000035078 AllianceGenome:MGI:2442842
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MTMR8; mMTMH3; LIP-STYX; 9430075G12Rik
    Summary
    Enables enzyme regulator activity. Predicted to be involved in several processes, including phosphatidylinositol dephosphorylation; protein stabilization; and regulation of dephosphorylation. Predicted to act upstream of or within endocytosis. Predicted to be located in cytosol. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and membrane. Is expressed in cranial ganglion; dorsal root ganglion; and trigeminal nerve. Orthologous to human MTMR9 (myotubularin related protein 9). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 15.6), whole brain E14.5 (RPKM 14.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    14 D1; 14 33.32 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (63757100..63781402, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (63519651..63544027, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_36924 Neighboring gene family with sequence similarity 167, member A Neighboring gene STARR-seq mESC enhancer starr_36926 Neighboring gene predicted gene 17232 Neighboring gene L-threonine dehydrogenase Neighboring gene STARR-positive B cell enhancer ABC_E8564 Neighboring gene VISTA enhancer mm1542 Neighboring gene predicted gene 15918 Neighboring gene STARR-seq mESC enhancer starr_36930 Neighboring gene X-linked Kx blood group related 6 Neighboring gene STARR-seq mESC enhancer starr_36931 Neighboring gene predicted gene, 38524

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The role of myotubularin-related phosphatases in the control of autophagy and programmed cell death. Zou J, et al. Adv Biol Regul, 2012 Jan. PMID 22056831, Free PMC Article
    2. Lipid phosphatases identified by screening a mouse phosphatase shRNA library regulate T-cell differentiation and protein kinase B AKT signaling. Guo L, et al. Proc Natl Acad Sci U S A, 2013 May 14. PMID 23630283, Free PMC Article
    3. Regulation of leptin by agouti. Claycombe KJ, et al. Physiol Genomics, 2000 Apr 27. PMID 11015588
    4. Sequential breakdown of 3-phosphorylated phosphoinositides is essential for the completion of macropinocytosis. Maekawa M, et al. Proc Natl Acad Sci U S A, 2014 Mar 18. PMID 24591580, Free PMC Article
    5. Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9. Mochizuki Y, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12890864, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MTMR7 forms a complex with MTMR9 and dephosphorylates phosphatidylinositol 3-phosphate and Ins(1,3)P2 in neuronal cells.
      Title: Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC54783

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein phosphatase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylinositol dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of phosphatidylinositol dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    myotubularin-related protein 9
    Names
    inactive phosphatidylinositol 3-phosphatase 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177594.1 → NP_808262.1  myotubularin-related protein 9

      See identical proteins and their annotated locations for NP_808262.1

      Status: PROVISIONAL

      Source sequence(s)
      BC046275
      Consensus CDS
      CCDS27203.1
      UniProtKB/Swiss-Prot
      A6H6P1, Q80XL4, Q9Z2D0
      UniProtKB/TrEMBL
      Q3U896
      Related
      ENSMUSP00000059894.6, ENSMUST00000058679.7
      Conserved Domains (2) summary
      cd13211
      Location:1 → 97
      PH-GRAM_MTMR9; Myotubularian (MTM) related 9 protein (MTMR9) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam06602
      Location:108 → 444
      Myotub-related; Myotubularin-like phosphatase domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      63757100..63781402 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247706.2 → XP_030103566.1  myotubularin-related protein 9 isoform X1

      UniProtKB/TrEMBL
      Q3U896
      Conserved Domains (1) summary
      pfam06602
      Location:23 → 360
      Myotub-related; Myotubularin-like phosphatase domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z2D0.2 GenPept UniProtKB/Swiss-Prot:Q9Z2D0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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