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    Eomes eomesodermin [ Mus musculus (house mouse) ]

    Gene ID: 13813, updated on 1-Oct-2021

    Summary

    Official Symbol
    Eomesprovided by MGI
    Official Full Name
    eomesoderminprovided by MGI
    Primary source
    MGI:MGI:1201683
    See related
    Ensembl:ENSMUSG00000032446
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tbr; Tbr2; TBR-2; C77258
    Expression
    Biased expression in CNS E14 (RPKM 10.8), frontal lobe adult (RPKM 6.7) and 6 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Eomes in Genome Data Viewer
    Location:
    9 70.21 cM; 9 F3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (118307254..118315200)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (118478186..118486132)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (118387307..118395250)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene pluripotency associated transcript 11 Neighboring gene predicted gene, 33285 Neighboring gene predicted gene, 33408 Neighboring gene predicted gene, 22479 Neighboring gene predicted gene, 33460 Neighboring gene golgi autoantigen, golgin subfamily a, 4 Neighboring gene family with sequence similarity 64, member A pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in CD8-positive, alpha-beta T cell differentiation involved in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in CD8-positive, alpha-beta T cell differentiation involved in immune response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in CD8-positive, alpha-beta T cell differentiation involved in immune response ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within anatomical structure morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within blastocyst development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in brain development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cardioblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell differentiation involved in embryonic placenta development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell fate specification IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cerebral cortex neuron differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cerebral cortex regionalization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within endoderm development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within endoderm formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in endoderm formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in endodermal cell fate specification IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within endodermal cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within gastrulation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within interferon-gamma production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within mesendoderm development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mesoderm formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within mesoderm formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mesodermal to mesenchymal transition involved in gastrulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within olfactory bulb development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within skeletal muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within trophectodermal cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within trophectodermal cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in intracellular anatomical structure IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    eomesodermin homolog
    Names
    T-box brain protein 2
    T-brain-2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164789.1NP_001158261.1  eomesodermin homolog isoform 2

      See identical proteins and their annotated locations for NP_001158261.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      BB611989, BC094319
      Consensus CDS
      CCDS52960.1
      UniProtKB/Swiss-Prot
      O54839
      Related
      ENSMUSP00000107393.2, ENSMUST00000111763.8
      Conserved Domains (2) summary
      cd00182
      Location:269462
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
      pfam16176
      Location:465686
      T-box_assoc; T-box transcription factor-associated
    2. NM_010136.3NP_034266.2  eomesodermin homolog isoform 1

      See identical proteins and their annotated locations for NP_034266.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BB611989, BC094319
      Consensus CDS
      CCDS23603.1
      UniProtKB/Swiss-Prot
      O54839
      Related
      ENSMUSP00000035020.9, ENSMUST00000035020.15
      Conserved Domains (2) summary
      cd00182
      Location:269462
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
      pfam16176
      Location:484705
      T-box_assoc; T-box transcription factor-associated

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      118307254..118315200
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511940.4XP_006512003.1  eomesodermin homolog isoform X1

      Related
      ENSMUSP00000118079.2, ENSMUST00000150633.2
      Conserved Domains (1) summary
      pfam00907
      Location:271458
      T-box
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