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    Ncoa2 nuclear receptor coactivator 2 [ Mus musculus (house mouse) ]

    Gene ID: 17978, updated on 25-Apr-2024

    Summary

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    Official Symbol
    Ncoa2provided by MGI
    Official Full Name
    nuclear receptor coactivator 2provided by MGI
    Primary source
    MGI:MGI:1276533
    See related
    Ensembl:ENSMUSG00000005886 AllianceGenome:MGI:1276533
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TIF2; Grip1; SRC-2; GRIP-1; KAT13C; NCoA-2; bHLHe75; D1Ertd433e
    Summary
    Enables several functions, including RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; chromatin binding activity; and nuclear receptor coactivator activity. Involved in circadian regulation of gene expression; locomotor rhythm; and regulation of glucose metabolic process. Acts upstream of or within several processes, including cellular response to Thyroglobulin triiodothyronine; regulation of transcription by RNA polymerase II; and response to progesterone. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; hemolymphoid system; and sensory organ. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human NCOA2 (nuclear receptor coactivator 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 10.9), thymus adult (RPKM 8.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 A3; 1 4.12 cM
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (13209329..13444451, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (13139105..13374227, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_00263 Neighboring gene predicted gene, 39592 Neighboring gene STARR-seq mESC enhancer starr_00267 Neighboring gene PR domain containing 14 Neighboring gene STARR-seq mESC enhancer starr_00268 Neighboring gene STARR-seq mESC enhancer starr_00269 Neighboring gene predicted gene, 23169 Neighboring gene STARR-positive B cell enhancer mm9_chr1:13362488-13362789 Neighboring gene STARR-positive B cell enhancer ABC_E9461 Neighboring gene predicted gene, 51852 Neighboring gene predicted gene, 39595 Neighboring gene signal recognition particle receptor ('docking protein') pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Transient activation of AMPK preceding left ventricular pressure overload reduces adverse remodeling and preserves left ventricular function. Nam DH, et al. FASEB J, 2019 Jan. PMID 30024790, Free PMC Article
    2. SRC-2 orchestrates polygenic inputs for fine-tuning glucose homeostasis. Fleet T, et al. Proc Natl Acad Sci U S A, 2015 Nov 3. PMID 26487680, Free PMC Article
    3. A novel mutation of the hGR gene causing Chrousos syndrome. Nicolaides NC, et al. Eur J Clin Invest, 2015 Aug. PMID 26031419
    4. SRC-2 coactivator deficiency decreases functional reserve in response to pressure overload of mouse heart. Reineke EL, et al. PLoS One, 2012. PMID 23300926, Free PMC Article
    5. Role of transcriptional coregulator GRIP1 in the anti-inflammatory actions of glucocorticoids. Chinenov Y, et al. Proc Natl Acad Sci U S A, 2012 Jul 17. PMID 22753499, Free PMC Article

    See all (145) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Steroid receptor coactivator-2 drives epithelial reprogramming that enables murine embryo implantation.
      Title: Steroid receptor coactivator-2 drives epithelial reprogramming that enables murine embryo implantation.
    2. Ncoa2 Promotes CD8+ T cell-Mediated Antitumor Immunity by Stimulating T-cell Activation via Upregulation of PGC-1alpha Critical for Mitochondrial Function.
      Title: Ncoa2 Promotes CD8+ T cell-Mediated Antitumor Immunity by Stimulating T-cell Activation via Upregulation of PGC-1α Critical for Mitochondrial Function.
    3. HEY1-NCOA2 expression modulates chondrogenic differentiation and induces mesenchymal chondrosarcoma in mice.
      Title: HEY1-NCOA2 expression modulates chondrogenic differentiation and induces mesenchymal chondrosarcoma in mice.
    4. SRC2 controls CD4[+] T cell activation via stimulating c-Myc-mediated upregulation of amino acid transporter Slc7a5.
      Title: SRC2 controls CD4(+) T cell activation via stimulating c-Myc-mediated upregulation of amino acid transporter Slc7a5.
    5. NCOA2 coordinates with the transcriptional KAT2B-NF-kappaB partner to trigger inflammation response in acute kidney injury.
      Title: NCOA2 coordinates with the transcriptional KAT2B-NF-κB partner to trigger inflammation response in acute kidney injury.
    6. Hypothalamic steroid receptor coactivator-2 regulates adaptations to fasting and overnutrition.
      Title: Hypothalamic steroid receptor coactivator-2 regulates adaptations to fasting and overnutrition.
    7. Transcription cofactor GRIP1 differentially affects myeloid cell-driven neuroinflammation and response to IFN-beta therapy.
      Title: Transcription cofactor GRIP1 differentially affects myeloid cell-driven neuroinflammation and response to IFN-β therapy.
    8. Results suggest that SRC-2 coordinates cardiomyocyte secretion of VEGF downstream of the two major angiogenic stimuli occurring during pressure overload bridging both hypertrophic and hypoxia-stimulated paracrine signaling.
      Title: Steroid receptor coactivator-2 (SRC-2) coordinates cardiomyocyte paracrine signaling to promote pressure overload-induced angiogenesis.
    9. studies demonstrate that SRC-2 provides an essential link between the behavioral activities influenced by light cues and the metabolic homeostasis maintained by the liver
      Title: Genetic and Environmental Models of Circadian Disruption Link SRC-2 Function to Hepatic Pathology.
    10. the expression of MOZ-TIF2 fusion protein represses the transcription of p16INK4a and p19ARF and blocks senescence.
      Title: Expression of the MOZ-TIF2 oncoprotein in mice represses senescence.
    Submit: New GeneRIF Correction See all GeneRIFs (45)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (5)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • 9530095N19

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA polymerase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables aryl hydrocarbon receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nuclear estrogen receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear glucocorticoid receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear receptor coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear receptor coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nuclear receptor coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear retinoic acid receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear retinoid X receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear thyroid hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription coactivator activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to Thyroglobulin triiodothyronine IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to hormone stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in circadian regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in circadian rhythm IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in locomotor rhythm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA transcription by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in peroxisome proliferator activated receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of adipose tissue development NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of female receptivity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of glucocorticoid receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of cellular response to insulin stimulus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of glucose metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of lipid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to progesterone IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within rhythmic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of RNA polymerase II transcription regulator complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription regulator complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    nuclear receptor coactivator 2
    Names
    glucocorticoid receptor interacting protein 1
    steroid receptor coactivator 2
    transcriptional intermediary factor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001302702.1 → NP_001289631.1  nuclear receptor coactivator 2 isoform b

      See identical proteins and their annotated locations for NP_001289631.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (c) differs in the 5' UTR and lacks an in-frame exon compared to variant a. The encoded isoform (b) is shorter than isoform a.
      Source sequence(s)
      AC091248, AK028964, AK035719, AK038781, AK042893, AK087443, BP761474, BU703942
      Consensus CDS
      CCDS35514.1
      UniProtKB/TrEMBL
      E9PV80, Q7TPU7
      Related
      ENSMUSP00000080413.5, ENSMUST00000081713.11
      Conserved Domains (9) summary
      smart00091
      Location:118 → 175
      PAS; PAS domain
      pfam09606
      Location:1056 → 1334
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18950
      Location:28 → 91
      bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
      pfam07469
      Location:1210 → 1267
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:1002 → 1046
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:636 → 709
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:268 → 378
      PAS_11; PAS domain
      pfam16279
      Location:731 → 816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463 → 587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein

    2. NM_008678.3 → NP_032704.2  nuclear receptor coactivator 2 isoform a

      See identical proteins and their annotated locations for NP_032704.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (a) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC091248, AK028964, AK035719, AK038781, AK042893, AK052117, AK087443, BP761474, BU703942
      Consensus CDS
      CCDS35515.1
      UniProtKB/Swiss-Prot
      E9QMH9, O09001, P97759, Q61026
      UniProtKB/TrEMBL
      Q7TPU7
      Related
      ENSMUSP00000006037.7, ENSMUST00000006037.13
      Conserved Domains (9) summary
      smart00091
      Location:118 → 175
      PAS; PAS domain
      pfam09606
      Location:921 → 1424
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18950
      Location:28 → 91
      bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
      pfam07469
      Location:1279 → 1336
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:1071 → 1115
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:636 → 709
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:268 → 378
      PAS_11; PAS domain
      pfam16279
      Location:731 → 816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463 → 587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      13209329..13444451 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162692.1 → XP_036018585.1  nuclear receptor coactivator 2 isoform X4

      UniProtKB/Swiss-Prot
      E9QMH9, O09001, P97759, Q61026
      UniProtKB/TrEMBL
      Q7TPU7
      Conserved Domains (9) summary
      smart00091
      Location:118 → 175
      PAS; PAS domain
      pfam09606
      Location:921 → 1424
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18950
      Location:28 → 91
      bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
      pfam07469
      Location:1279 → 1336
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:1071 → 1115
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:636 → 709
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:268 → 378
      PAS_11; PAS domain
      pfam16279
      Location:731 → 816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463 → 587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein

    2. XM_036162710.1 → XP_036018603.1  nuclear receptor coactivator 2 isoform X7

      UniProtKB/TrEMBL
      E9PV80, Q7TPU7
      Related
      ENSMUSP00000069509.7, ENSMUST00000068304.13
      Conserved Domains (9) summary
      smart00091
      Location:118 → 175
      PAS; PAS domain
      pfam09606
      Location:1056 → 1334
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18950
      Location:28 → 91
      bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
      pfam07469
      Location:1210 → 1267
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:1002 → 1046
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:636 → 709
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:268 → 378
      PAS_11; PAS domain
      pfam16279
      Location:731 → 816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463 → 587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein

    3. XM_030252088.1 → XP_030107948.1  nuclear receptor coactivator 2 isoform X3

      UniProtKB/TrEMBL
      Q7TPU7
      Conserved Domains (8) summary
      smart00091
      Location:118 → 175
      PAS; PAS domain
      pfam08815
      Location:1076 → 1121
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam07469
      Location:1284 → 1340
      DUF1518; Domain of unknown function (DUF1518)
      pfam08832
      Location:636 → 709
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:268 → 378
      PAS_11; PAS domain
      pfam16279
      Location:731 → 816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463 → 587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein
      cd18950
      Location:28 → 91
      bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins

    4. XM_036162655.1 → XP_036018548.1  nuclear receptor coactivator 2 isoform X1

      UniProtKB/TrEMBL
      Q7TPU7
      Conserved Domains (9) summary
      smart00091
      Location:118 → 175
      PAS; PAS domain
      pfam09606
      Location:1130 → 1408
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18950
      Location:28 → 91
      bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
      pfam07469
      Location:1284 → 1341
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:1076 → 1120
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:636 → 709
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:268 → 378
      PAS_11; PAS domain
      pfam16279
      Location:731 → 816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463 → 587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein

    5. XM_030252095.2 → XP_030107955.1  nuclear receptor coactivator 2 isoform X7

      UniProtKB/TrEMBL
      E9PV80, Q7TPU7
      Conserved Domains (9) summary
      smart00091
      Location:118 → 175
      PAS; PAS domain
      pfam09606
      Location:1056 → 1334
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18950
      Location:28 → 91
      bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
      pfam07469
      Location:1210 → 1267
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:1002 → 1046
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:636 → 709
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:268 → 378
      PAS_11; PAS domain
      pfam16279
      Location:731 → 816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463 → 587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein

    6. XM_036162694.1 → XP_036018587.1  nuclear receptor coactivator 2 isoform X4

      UniProtKB/Swiss-Prot
      E9QMH9, O09001, P97759, Q61026
      UniProtKB/TrEMBL
      Q7TPU7
      Conserved Domains (9) summary
      smart00091
      Location:118 → 175
      PAS; PAS domain
      pfam09606
      Location:921 → 1424
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18950
      Location:28 → 91
      bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
      pfam07469
      Location:1279 → 1336
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:1071 → 1115
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:636 → 709
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:268 → 378
      PAS_11; PAS domain
      pfam16279
      Location:731 → 816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463 → 587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein

    7. XM_036162714.1 → XP_036018607.1  nuclear receptor coactivator 2 isoform X7

      UniProtKB/TrEMBL
      E9PV80, Q7TPU7
      Conserved Domains (9) summary
      smart00091
      Location:118 → 175
      PAS; PAS domain
      pfam09606
      Location:1056 → 1334
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18950
      Location:28 → 91
      bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
      pfam07469
      Location:1210 → 1267
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:1002 → 1046
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:636 → 709
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:268 → 378
      PAS_11; PAS domain
      pfam16279
      Location:731 → 816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463 → 587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein

    8. XM_036162698.1 → XP_036018591.1  nuclear receptor coactivator 2 isoform X4

      UniProtKB/Swiss-Prot
      E9QMH9, O09001, P97759, Q61026
      UniProtKB/TrEMBL
      Q7TPU7
      Conserved Domains (9) summary
      smart00091
      Location:118 → 175
      PAS; PAS domain
      pfam09606
      Location:921 → 1424
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18950
      Location:28 → 91
      bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
      pfam07469
      Location:1279 → 1336
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:1071 → 1115
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:636 → 709
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:268 → 378
      PAS_11; PAS domain
      pfam16279
      Location:731 → 816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463 → 587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein

    9. XM_036162703.1 → XP_036018596.1  nuclear receptor coactivator 2 isoform X6

      UniProtKB/TrEMBL
      Q7TPU7
      Conserved Domains (9) summary
      smart00091
      Location:118 → 175
      PAS; PAS domain
      pfam09606
      Location:1056 → 1334
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18950
      Location:28 → 91
      bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
      pfam07469
      Location:1210 → 1267
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:1002 → 1046
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:636 → 709
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:268 → 378
      PAS_11; PAS domain
      pfam16279
      Location:731 → 816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463 → 587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein

    10. XM_030252090.2 → XP_030107950.1  nuclear receptor coactivator 2 isoform X5

      UniProtKB/TrEMBL
      Q7TPU7
      Conserved Domains (10) summary
      TIGR01628
      Location:902 → 1021
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      smart00091
      Location:118 → 175
      PAS; PAS domain
      pfam08815
      Location:1007 → 1052
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam09606
      Location:1070 → 1360
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam07469
      Location:1215 → 1271
      DUF1518; Domain of unknown function (DUF1518)
      pfam08832
      Location:636 → 709
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:268 → 378
      PAS_11; PAS domain
      pfam16279
      Location:731 → 816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463 → 587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein
      cd18950
      Location:28 → 91
      bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins

    11. XM_030252087.2 → XP_030107947.1  nuclear receptor coactivator 2 isoform X2

      UniProtKB/TrEMBL
      Q7TPU7
      Conserved Domains (9) summary
      smart00091
      Location:118 → 175
      PAS; PAS domain
      pfam08815
      Location:1071 → 1116
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam09606
      Location:921 → 1424
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam07469
      Location:1279 → 1335
      DUF1518; Domain of unknown function (DUF1518)
      pfam08832
      Location:636 → 709
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:268 → 378
      PAS_11; PAS domain
      pfam16279
      Location:731 → 816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463 → 587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein
      cd18950
      Location:28 → 91
      bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins

    12. XM_030252072.2 → XP_030107932.1  nuclear receptor coactivator 2 isoform X1

      UniProtKB/TrEMBL
      Q7TPU7
      Conserved Domains (9) summary
      smart00091
      Location:118 → 175
      PAS; PAS domain
      pfam09606
      Location:1130 → 1408
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18950
      Location:28 → 91
      bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
      pfam07469
      Location:1284 → 1341
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:1076 → 1120
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:636 → 709
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:268 → 378
      PAS_11; PAS domain
      pfam16279
      Location:731 → 816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463 → 587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein

    13. XM_030252093.2 → XP_030107953.1  nuclear receptor coactivator 2 isoform X6

      UniProtKB/TrEMBL
      Q7TPU7
      Conserved Domains (9) summary
      smart00091
      Location:118 → 175
      PAS; PAS domain
      pfam09606
      Location:1056 → 1334
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18950
      Location:28 → 91
      bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
      pfam07469
      Location:1210 → 1267
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:1002 → 1046
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:636 → 709
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:268 → 378
      PAS_11; PAS domain
      pfam16279
      Location:731 → 816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463 → 587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein

    14. XM_017319241.3 → XP_017174730.1  nuclear receptor coactivator 2 isoform X5

      UniProtKB/TrEMBL
      Q7TPU7
      Conserved Domains (10) summary
      TIGR01628
      Location:902 → 1021
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      smart00091
      Location:118 → 175
      PAS; PAS domain
      pfam08815
      Location:1007 → 1052
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam09606
      Location:1070 → 1360
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam07469
      Location:1215 → 1271
      DUF1518; Domain of unknown function (DUF1518)
      pfam08832
      Location:636 → 709
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:268 → 378
      PAS_11; PAS domain
      pfam16279
      Location:731 → 816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463 → 587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein
      cd18950
      Location:28 → 91
      bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins

    15. XM_017319229.3 → XP_017174718.1  nuclear receptor coactivator 2 isoform X1

      UniProtKB/TrEMBL
      Q7TPU7
      Conserved Domains (9) summary
      smart00091
      Location:118 → 175
      PAS; PAS domain
      pfam09606
      Location:1130 → 1408
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18950
      Location:28 → 91
      bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
      pfam07469
      Location:1284 → 1341
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:1076 → 1120
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:636 → 709
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:268 → 378
      PAS_11; PAS domain
      pfam16279
      Location:731 → 816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463 → 587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein

    16. XM_030252082.2 → XP_030107942.1  nuclear receptor coactivator 2 isoform X1

      UniProtKB/TrEMBL
      Q7TPU7
      Conserved Domains (9) summary
      smart00091
      Location:118 → 175
      PAS; PAS domain
      pfam09606
      Location:1130 → 1408
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18950
      Location:28 → 91
      bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
      pfam07469
      Location:1284 → 1341
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:1076 → 1120
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:636 → 709
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:268 → 378
      PAS_11; PAS domain
      pfam16279
      Location:731 → 816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463 → 587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein

    17. XM_030252068.2 → XP_030107928.1  nuclear receptor coactivator 2 isoform X1

      UniProtKB/TrEMBL
      Q7TPU7
      Conserved Domains (9) summary
      smart00091
      Location:118 → 175
      PAS; PAS domain
      pfam09606
      Location:1130 → 1408
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18950
      Location:28 → 91
      bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
      pfam07469
      Location:1284 → 1341
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:1076 → 1120
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:636 → 709
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:268 → 378
      PAS_11; PAS domain
      pfam16279
      Location:731 → 816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463 → 587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein

    18. XM_017319235.3 → XP_017174724.1  nuclear receptor coactivator 2 isoform X1

      UniProtKB/TrEMBL
      Q7TPU7
      Conserved Domains (9) summary
      smart00091
      Location:118 → 175
      PAS; PAS domain
      pfam09606
      Location:1130 → 1408
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18950
      Location:28 → 91
      bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
      pfam07469
      Location:1284 → 1341
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:1076 → 1120
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:636 → 709
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:268 → 378
      PAS_11; PAS domain
      pfam16279
      Location:731 → 816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463 → 587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein

    19. XM_036162665.1 → XP_036018558.1  nuclear receptor coactivator 2 isoform X1

      UniProtKB/TrEMBL
      Q7TPU7
      Conserved Domains (9) summary
      smart00091
      Location:118 → 175
      PAS; PAS domain
      pfam09606
      Location:1130 → 1408
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18950
      Location:28 → 91
      bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
      pfam07469
      Location:1284 → 1341
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:1076 → 1120
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:636 → 709
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:268 → 378
      PAS_11; PAS domain
      pfam16279
      Location:731 → 816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463 → 587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein

    20. XM_036162709.1 → XP_036018602.1  nuclear receptor coactivator 2 isoform X6

      UniProtKB/TrEMBL
      Q7TPU7
      Conserved Domains (9) summary
      smart00091
      Location:118 → 175
      PAS; PAS domain
      pfam09606
      Location:1056 → 1334
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18950
      Location:28 → 91
      bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
      pfam07469
      Location:1210 → 1267
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:1002 → 1046
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:636 → 709
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:268 → 378
      PAS_11; PAS domain
      pfam16279
      Location:731 → 816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463 → 587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein

    21. XM_017319233.3 → XP_017174722.1  nuclear receptor coactivator 2 isoform X1

      UniProtKB/TrEMBL
      Q7TPU7
      Conserved Domains (9) summary
      smart00091
      Location:118 → 175
      PAS; PAS domain
      pfam09606
      Location:1130 → 1408
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18950
      Location:28 → 91
      bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
      pfam07469
      Location:1284 → 1341
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:1076 → 1120
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:636 → 709
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:268 → 378
      PAS_11; PAS domain
      pfam16279
      Location:731 → 816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463 → 587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein

    22. XM_030252070.2 → XP_030107930.1  nuclear receptor coactivator 2 isoform X1

      UniProtKB/TrEMBL
      Q7TPU7
      Conserved Domains (9) summary
      smart00091
      Location:118 → 175
      PAS; PAS domain
      pfam09606
      Location:1130 → 1408
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18950
      Location:28 → 91
      bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
      pfam07469
      Location:1284 → 1341
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:1076 → 1120
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:636 → 709
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:268 → 378
      PAS_11; PAS domain
      pfam16279
      Location:731 → 816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463 → 587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein

    23. XM_017319232.3 → XP_017174721.1  nuclear receptor coactivator 2 isoform X1

      UniProtKB/TrEMBL
      Q7TPU7
      Conserved Domains (9) summary
      smart00091
      Location:118 → 175
      PAS; PAS domain
      pfam09606
      Location:1130 → 1408
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18950
      Location:28 → 91
      bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
      pfam07469
      Location:1284 → 1341
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:1076 → 1120
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:636 → 709
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:268 → 378
      PAS_11; PAS domain
      pfam16279
      Location:731 → 816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463 → 587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein

    24. XM_030252066.2 → XP_030107926.1  nuclear receptor coactivator 2 isoform X1

      UniProtKB/TrEMBL
      Q7TPU7
      Conserved Domains (9) summary
      smart00091
      Location:118 → 175
      PAS; PAS domain
      pfam09606
      Location:1130 → 1408
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18950
      Location:28 → 91
      bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
      pfam07469
      Location:1284 → 1341
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:1076 → 1120
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:636 → 709
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:268 → 378
      PAS_11; PAS domain
      pfam16279
      Location:731 → 816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463 → 587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein

    25. XM_036162671.1 → XP_036018564.1  nuclear receptor coactivator 2 isoform X1

      UniProtKB/TrEMBL
      Q7TPU7
      Conserved Domains (9) summary
      smart00091
      Location:118 → 175
      PAS; PAS domain
      pfam09606
      Location:1130 → 1408
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18950
      Location:28 → 91
      bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
      pfam07469
      Location:1284 → 1341
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:1076 → 1120
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:636 → 709
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:268 → 378
      PAS_11; PAS domain
      pfam16279
      Location:731 → 816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463 → 587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein

    26. XM_036162677.1 → XP_036018570.1  nuclear receptor coactivator 2 isoform X1

      UniProtKB/TrEMBL
      Q7TPU7
      Conserved Domains (9) summary
      smart00091
      Location:118 → 175
      PAS; PAS domain
      pfam09606
      Location:1130 → 1408
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18950
      Location:28 → 91
      bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
      pfam07469
      Location:1284 → 1341
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:1076 → 1120
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:636 → 709
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:268 → 378
      PAS_11; PAS domain
      pfam16279
      Location:731 → 816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463 → 587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein

    27. XM_030252075.2 → XP_030107935.1  nuclear receptor coactivator 2 isoform X1

      UniProtKB/TrEMBL
      Q7TPU7
      Conserved Domains (9) summary
      smart00091
      Location:118 → 175
      PAS; PAS domain
      pfam09606
      Location:1130 → 1408
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18950
      Location:28 → 91
      bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
      pfam07469
      Location:1284 → 1341
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:1076 → 1120
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:636 → 709
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:268 → 378
      PAS_11; PAS domain
      pfam16279
      Location:731 → 816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463 → 587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein

    28. XM_030252077.2 → XP_030107937.1  nuclear receptor coactivator 2 isoform X1

      UniProtKB/TrEMBL
      Q7TPU7
      Conserved Domains (9) summary
      smart00091
      Location:118 → 175
      PAS; PAS domain
      pfam09606
      Location:1130 → 1408
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18950
      Location:28 → 91
      bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
      pfam07469
      Location:1284 → 1341
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:1076 → 1120
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:636 → 709
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:268 → 378
      PAS_11; PAS domain
      pfam16279
      Location:731 → 816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463 → 587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein

    29. XM_030252083.2 → XP_030107943.1  nuclear receptor coactivator 2 isoform X1

      UniProtKB/TrEMBL
      Q7TPU7
      Conserved Domains (9) summary
      smart00091
      Location:118 → 175
      PAS; PAS domain
      pfam09606
      Location:1130 → 1408
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18950
      Location:28 → 91
      bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins
      pfam07469
      Location:1284 → 1341
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:1076 → 1120
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:636 → 709
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:268 → 378
      PAS_11; PAS domain
      pfam16279
      Location:731 → 816
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:463 → 587
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001077695.1: Suppressed sequence

      Description
      NM_001077695.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61026.3 GenPept UniProtKB/Swiss-Prot:Q61026

    Gene LinkOut

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