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    Adam22 a disintegrin and metallopeptidase domain 22 [ Mus musculus (house mouse) ]

    Gene ID: 11496, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Adam22provided by MGI
    Official Full Name
    a disintegrin and metallopeptidase domain 22provided by MGI
    Primary source
    MGI:MGI:1340046
    See related
    Ensembl:ENSMUSG00000040537 AllianceGenome:MGI:1340046
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MDC2; 2900022I03Rik
    Summary
    This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. The protein encoded by this gene is believed to lack metalloproteinase activity due to the lack of a critical catalytic motif. Mice lacking the encoded protein exhibit severe ataxia, hypomyelination and premature death. Alternative splicing results in multiple transcript variants encoding different isoforms, some of which may undergo similar processing. [provided by RefSeq, May 2016]
    Expression
    Biased expression in cerebellum adult (RPKM 18.0), cortex adult (RPKM 14.5) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Adam22 in Genome Data Viewer
    Location:
    5 A1; 5 3.39 cM
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (8122353..8418312, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (8072347..8368312, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene 15731 Neighboring gene predicted gene, 52802 Neighboring gene 60S ribosomal protein L27 pseudogene Neighboring gene STARR-seq mESC enhancer starr_12380 Neighboring gene sorcin Neighboring gene STARR-seq mESC enhancer starr_12381 Neighboring gene predicted gene, 21759 Neighboring gene STARR-seq mESC enhancer starr_12382 Neighboring gene STARR-seq mESC enhancer starr_12383 Neighboring gene predicted gene, 23993 Neighboring gene STARR-seq mESC enhancer starr_12384 Neighboring gene ribosomal protein L19 pseudogene Neighboring gene STARR-seq mESC enhancer starr_12387 Neighboring gene solute carrier family 25, member 40 Neighboring gene DBF4 zinc finger Neighboring gene STARR-positive B cell enhancer mm9_chr5:8489752-8490052 Neighboring gene STARR-seq mESC enhancer starr_12390 Neighboring gene RUN domain containing 3B Neighboring gene ATP-binding cassette, sub-family B member 1A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. miR-221-3p inhibits oxidized low-density lipoprotein induced oxidative stress and apoptosis via targeting a disintegrin and metalloprotease-22. Zhuang X, et al. J Cell Biochem, 2019 Apr. PMID 30362166
    2. A Disintegrin and Metalloprotease-22 Attenuates Hypertrophic Remodeling in Mice Through Inhibition of the Protein Kinase B Signaling Pathway. Ren L, et al. J Am Heart Assoc, 2018 Jan 22. PMID 29358191, Free PMC Article
    3. LGI1 and LGI4 bind to ADAM22, ADAM23 and ADAM11. Sagane K, et al. Int J Biol Sci, 2008. PMID 18974846, Free PMC Article
    4. LGI1-ADAM22-MAGUK configures transsynaptic nanoalignment for synaptic transmission and epilepsy prevention. Fukata Y, et al. Proc Natl Acad Sci U S A, 2021 Jan 19. PMID 33397806, Free PMC Article
    5. The LGI1-ADAM22 protein complex directs synapse maturation through regulation of PSD-95 function. Lovero KL, et al. Proc Natl Acad Sci U S A, 2015 Jul 28. PMID 26178195, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A disintegrin and metalloproteinase 22 activates integrin beta1 through its disintegrin domain to promote the progression of pituitary adenoma.
      Title: A disintegrin and metalloproteinase 22 activates integrin β1 through its disintegrin domain to promote the progression of pituitary adenoma.
    2. LGI1-ADAM22-MAGUK configures transsynaptic nanoalignment for synaptic transmission and epilepsy prevention.
      Title: LGI1-ADAM22-MAGUK configures transsynaptic nanoalignment for synaptic transmission and epilepsy prevention.
    3. Results have identified ADAM22 as the most potential target of miR-221, and silencing ADAM22 resulted in a reduced foam cell formation and cell apoptosis.
      Title: miR-221-3p inhibits oxidized low-density lipoprotein induced oxidative stress and apoptosis via targeting a disintegrin and metalloprotease-22.
    4. ADAM22 negatively regulates cardiac myocyte AKT activation and the process of cardiac hypertrophy.
      Title: A Disintegrin and Metalloprotease-22 Attenuates Hypertrophic Remodeling in Mice Through Inhibition of the Protein Kinase B Signaling Pathway.
    5. LGI1 and ADAM22 form an essential synaptic organizing complex that coordinates the maturation of excitatory synapses by regulating the functional incorporation of PSD-95
      Title: The LGI1-ADAM22 protein complex directs synapse maturation through regulation of PSD-95 function.
    6. Interaction proteomics revealed the interactors of Caspr2, including CNTN2, KCNAs, members of the ADAM family (ADAM22, ADAM23 and ADAM11), members of LGI family and MAGUKs (DLGs and MPPs).
      Title: Interaction proteomics of canonical Caspr2 (CNTNAP2) reveals the presence of two Caspr2 isoforms with overlapping interactomes.
    7. ADAM22 is an axonal component of the Kv1 K+ channel complex that recruits membrane-associated guanylate kinase to juxtaparanodes
      Title: ADAM22, a Kv1 channel-interacting protein, recruits membrane-associated guanylate kinases to juxtaparanodes of myelinated axons.
    8. study identified LGI1 as a specific binding partner of ADAM22 protein from mouse brain, and demonstrated the specific interaction between LGI1 and ADAM22
      Title: LGI1 and LGI4 bind to ADAM22, ADAM23 and ADAM11.
    9. ADAM22 is closely involved in the correct functioning of the nervous system.
      Title: Ataxia and peripheral nerve hypomyelination in ADAM22-deficient mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within Schwann cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within adult locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within gliogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within myelination in peripheral nervous system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neurotransmitter receptor localization to postsynaptic specialization membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in neurotransmitter receptor localization to postsynaptic specialization membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in axon initial segment ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic density membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynaptic density membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic density membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    disintegrin and metalloproteinase domain-containing protein 22
    Names
    a disintegrin and metalloprotease domain (ADAM) 22

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007220.4 → NP_001007221.1  disintegrin and metalloproteinase domain-containing protein 22 isoform a precursor

      See identical proteins and their annotated locations for NP_001007221.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1, also known as alpha or A04) encodes isoform a. This isoform (a) may undergo protein processing similar to isoform 5.
      Source sequence(s)
      AC140364, AC152165, AC156022
      Consensus CDS
      CCDS19080.1
      UniProtKB/TrEMBL
      A4FUT9
      Related
      ENSMUSP00000049120.8, ENSMUST00000046838.14
      Conserved Domains (5) summary
      smart00608
      Location:528 → 669
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:237 → 434
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:451 → 525
      Disintegrin; Disintegrin
      pfam01421
      Location:237 → 436
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:73 → 185
      Pep_M12B_propep; Reprolysin family propeptide

    2. NM_001007221.4 → NP_001007222.1  disintegrin and metalloproteinase domain-containing protein 22 isoform b precursor

      See identical proteins and their annotated locations for NP_001007222.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2, also known as beta or A05) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a. This isoform (b) may undergo protein processing similar to isoform 5.
      Source sequence(s)
      AC140364, AC152165, AC156022
      UniProtKB/TrEMBL
      A4FUT9
      Conserved Domains (5) summary
      smart00608
      Location:528 → 669
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:237 → 434
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:451 → 525
      Disintegrin; Disintegrin
      pfam01421
      Location:237 → 436
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:73 → 185
      Pep_M12B_propep; Reprolysin family propeptide

    3. NM_001098225.3 → NP_001091695.1  disintegrin and metalloproteinase domain-containing protein 22 isoform c precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3, also known as G03) contains multiple differences in the 3' coding region and differs in the 3' UTR compared variant 1. The encoded isoform (c) has a distinct C-terminus and is longer than isoform a. This isoform (c) may undergo protein processing similar to isoform 5.
      Source sequence(s)
      AC140364, AC152165, AC156022
      Consensus CDS
      CCDS51411.1
      UniProtKB/TrEMBL
      A4FUT9
      Related
      ENSMUSP00000055000.8, ENSMUST00000050166.14
      Conserved Domains (5) summary
      smart00608
      Location:528 → 669
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:237 → 434
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:451 → 525
      Disintegrin; Disintegrin
      pfam01421
      Location:237 → 436
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:73 → 185
      Pep_M12B_propep; Reprolysin family propeptide

    4. NM_001310439.2 → NP_001297368.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 4 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4, also known as G07) contains multiple differences in the 3' coding region and differs in the 3' UTR compared variant 1. The encoded isoform (c) has a distinct C-terminus and is longer than isoform a. This isoform (4) may undergo protein processing similar to isoform 5.
      Source sequence(s)
      AC140364, AC152165, AC156022
      Consensus CDS
      CCDS80205.1
      UniProtKB/TrEMBL
      A4FUT9
      Related
      ENSMUSP00000111046.3, ENSMUST00000115388.9
      Conserved Domains (5) summary
      smart00608
      Location:528 → 669
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:237 → 434
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:451 → 525
      Disintegrin; Disintegrin
      pfam01421
      Location:237 → 436
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:73 → 185
      Pep_M12B_propep; Reprolysin family propeptide

    5. NM_001310440.2 → NP_001297369.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 5 preproprotein

      See identical proteins and their annotated locations for NP_001297369.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5, also known as G01) differs in the 3' coding region and 3' UTR compared to variant 1. The encoded isoform (c) has a longer C-terminus than isoform a.
      Source sequence(s)
      AC140364, AC152165, AC156022
      Consensus CDS
      CCDS80207.1
      UniProtKB/Swiss-Prot
      Q5TLI8, Q5TLI9, Q5TLJ0, Q5TLJ1, Q5TLJ2, Q5TLJ3, Q5TLJ4, Q5TLJ5, Q5TLJ6, Q5TLJ7, Q5TLJ8, Q5TLJ9, Q5TLK0, Q5TLK1, Q5TLK2, Q5TLK3, Q5TLK4, Q5TLK5, Q5TLK6, Q5TLK7, Q5TLK8, Q8BSF2, Q9R1V5, Q9R1V6
      UniProtKB/TrEMBL
      A4FUT9, D6QSS8
      Related
      ENSMUSP00000086139.5, ENSMUST00000088761.11
      Conserved Domains (5) summary
      smart00608
      Location:528 → 669
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:237 → 434
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:451 → 525
      Disintegrin; Disintegrin
      pfam01421
      Location:237 → 436
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:73 → 185
      Pep_M12B_propep; Reprolysin family propeptide

    6. NM_001418085.1 → NP_001405014.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 6 precursor

      Status: REVIEWED

      Source sequence(s)
      AC140364, AC152165, AC156022

    7. NM_001418086.1 → NP_001405015.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 7 precursor

      Status: REVIEWED

      Source sequence(s)
      AC140364, AC152165, AC156022

    8. NM_001418087.1 → NP_001405016.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 8 precursor

      Status: REVIEWED

      Source sequence(s)
      AC140364, AC152165, AC156022
      UniProtKB/TrEMBL
      D3YUQ0
      Related
      ENSMUSP00000111043.2, ENSMUST00000115385.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      8122353..8418312 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503534.5 → XP_006503597.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X7

      UniProtKB/TrEMBL
      A4FUT9
      Conserved Domains (5) summary
      smart00608
      Location:528 → 669
      ACR; ADAM Cysteine-Rich Domain
      pfam07974
      Location:677 → 709
      EGF_2; EGF-like domain
      pfam00200
      Location:451 → 524
      Disintegrin
      pfam01421
      Location:237 → 436
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:48 → 186
      Pep_M12B_propep; Reprolysin family propeptide

    2. XM_006503540.5 → XP_006503603.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X12

      UniProtKB/TrEMBL
      A4FUT9, D3YUP9
      Related
      ENSMUSP00000111044.2, ENSMUST00000115386.8
      Conserved Domains (5) summary
      smart00608
      Location:528 → 669
      ACR; ADAM Cysteine-Rich Domain
      pfam07974
      Location:677 → 709
      EGF_2; EGF-like domain
      pfam00200
      Location:451 → 524
      Disintegrin
      pfam01421
      Location:237 → 436
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:48 → 186
      Pep_M12B_propep; Reprolysin family propeptide

    3. XM_006503536.5 → XP_006503599.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X10

      UniProtKB/TrEMBL
      A4FUT9
      Conserved Domains (5) summary
      smart00608
      Location:528 → 669
      ACR; ADAM Cysteine-Rich Domain
      pfam07974
      Location:677 → 709
      EGF_2; EGF-like domain
      pfam00200
      Location:451 → 524
      Disintegrin
      pfam01421
      Location:237 → 436
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:48 → 186
      Pep_M12B_propep; Reprolysin family propeptide

    4. XM_006503537.5 → XP_006503600.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X11

      UniProtKB/TrEMBL
      A4FUT9
      Conserved Domains (5) summary
      smart00608
      Location:528 → 669
      ACR; ADAM Cysteine-Rich Domain
      pfam07974
      Location:677 → 709
      EGF_2; EGF-like domain
      pfam00200
      Location:451 → 524
      Disintegrin
      pfam01421
      Location:237 → 436
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:48 → 186
      Pep_M12B_propep; Reprolysin family propeptide

    5. XM_006503532.5 → XP_006503595.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X5

      UniProtKB/TrEMBL
      A4FUT9
      Conserved Domains (5) summary
      smart00608
      Location:528 → 669
      ACR; ADAM Cysteine-Rich Domain
      pfam07974
      Location:677 → 709
      EGF_2; EGF-like domain
      pfam00200
      Location:451 → 524
      Disintegrin
      pfam01421
      Location:237 → 436
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:48 → 186
      Pep_M12B_propep; Reprolysin family propeptide

    6. XM_006503533.5 → XP_006503596.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X6

      UniProtKB/TrEMBL
      A4FUT9
      Conserved Domains (5) summary
      smart00608
      Location:528 → 669
      ACR; ADAM Cysteine-Rich Domain
      pfam07974
      Location:677 → 709
      EGF_2; EGF-like domain
      pfam00200
      Location:451 → 524
      Disintegrin
      pfam01421
      Location:237 → 436
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:48 → 186
      Pep_M12B_propep; Reprolysin family propeptide

    7. XM_006503530.5 → XP_006503593.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X3

      UniProtKB/TrEMBL
      A4FUT9
      Conserved Domains (5) summary
      smart00608
      Location:528 → 669
      ACR; ADAM Cysteine-Rich Domain
      pfam07974
      Location:677 → 709
      EGF_2; EGF-like domain
      pfam00200
      Location:451 → 524
      Disintegrin
      pfam01421
      Location:237 → 436
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:48 → 186
      Pep_M12B_propep; Reprolysin family propeptide

    8. XM_006503528.5 → XP_006503591.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X1

      UniProtKB/TrEMBL
      A4FUT9
      Conserved Domains (5) summary
      smart00608
      Location:528 → 669
      ACR; ADAM Cysteine-Rich Domain
      pfam07974
      Location:677 → 709
      EGF_2; EGF-like domain
      pfam00200
      Location:451 → 524
      Disintegrin
      pfam01421
      Location:237 → 436
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:48 → 186
      Pep_M12B_propep; Reprolysin family propeptide

    9. XM_006503535.5 → XP_006503598.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X8

      UniProtKB/TrEMBL
      A4FUT9
      Conserved Domains (4) summary
      smart00608
      Location:528 → 669
      ACR; ADAM Cysteine-Rich Domain
      pfam00200
      Location:451 → 524
      Disintegrin
      pfam01421
      Location:237 → 436
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:48 → 186
      Pep_M12B_propep; Reprolysin family propeptide

    10. XM_006503531.5 → XP_006503594.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X4

      UniProtKB/TrEMBL
      A4FUT9
      Conserved Domains (5) summary
      smart00608
      Location:528 → 669
      ACR; ADAM Cysteine-Rich Domain
      pfam07974
      Location:677 → 709
      EGF_2; EGF-like domain
      pfam00200
      Location:451 → 524
      Disintegrin
      pfam01421
      Location:237 → 436
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:48 → 186
      Pep_M12B_propep; Reprolysin family propeptide

    11. XM_006503529.5 → XP_006503592.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X2

      UniProtKB/TrEMBL
      A4FUT9
      Conserved Domains (5) summary
      smart00608
      Location:528 → 669
      ACR; ADAM Cysteine-Rich Domain
      pfam07974
      Location:677 → 709
      EGF_2; EGF-like domain
      pfam00200
      Location:451 → 524
      Disintegrin
      pfam01421
      Location:237 → 436
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:48 → 186
      Pep_M12B_propep; Reprolysin family propeptide

    12. XM_030254064.2 → XP_030109924.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X13

      UniProtKB/TrEMBL
      A4FUT9
      Conserved Domains (4) summary
      smart00608
      Location:528 → 669
      ACR; ADAM Cysteine-Rich Domain
      pfam00200
      Location:451 → 524
      Disintegrin
      pfam01421
      Location:237 → 436
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:48 → 186
      Pep_M12B_propep; Reprolysin family propeptide

    RNA

    1. XR_376691.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9R1V6.2 GenPept UniProtKB/Swiss-Prot:Q9R1V6

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