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    Recql RecQ protein-like [ Mus musculus (house mouse) ]

    Gene ID: 19691, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Recqlprovided by MGI
    Official Full Name
    RecQ protein-likeprovided by MGI
    Primary source
    MGI:MGI:103021
    See related
    Ensembl:ENSMUSG00000030243 AllianceGenome:MGI:103021
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RecQ1
    Summary
    Predicted to enable 3'-5' DNA helicase activity; ATP-dependent DNA/DNA annealing activity; and four-way junction helicase activity. Predicted to be involved in DNA unwinding involved in DNA replication and double-strand break repair via homologous recombination. Predicted to be located in nucleoplasm. Predicted to be active in chromosome and cytoplasm. Is expressed in cerebral cortex subventricular zone. Human ortholog(s) of this gene implicated in hepatocellular carcinoma; lung cancer; and pancreatic cancer. Orthologous to human RECQL (RecQ like helicase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 4.8), CNS E14 (RPKM 3.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    6 G2; 6 73.91 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (142296068..142332802, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (142350342..142387100, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene solute carrier organic anion transporter family, member 1a5 Neighboring gene STARR-seq mESC enhancer starr_17703 Neighboring gene islet amyloid polypeptide Neighboring gene 60S ribosomal protein L18 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E6502 Neighboring gene pyridine nucleotide-disulphide oxidoreductase domain 1 Neighboring gene STARR-positive B cell enhancer ABC_E1716 Neighboring gene golgi transport 1B Neighboring gene spexin hormone

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. RECQL, a member of the RecQ family of DNA helicases, suppresses chromosomal instability. Sharma S, et al. Mol Cell Biol, 2007 Mar. PMID 17158923, Free PMC Article
    2. Cloning of two isoforms of mouse DNA helicase Q1/RecQL cDNA; alpha form is expressed ubiquitously and beta form specifically in the testis. Wang WS, et al. Biochim Biophys Acta, 1998 Nov 26. PMID 9838113
    3. Chromosomal localization of the gene encoding the human DNA helicase RECQL and its mouse homologue. Puranam KL, et al. Genomics, 1995 Apr 10. PMID 7607686
    4. RecQ helicases: suppressors of tumorigenesis and premature aging. Bachrati CZ, et al. Biochem J, 2003 Sep 15. PMID 12803543, Free PMC Article
    5. Mapping of six germ-cell-specific genes to mouse chromosomes. Matsui M, et al. Mamm Genome, 1997. PMID 9337410

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Recql suppresses chromosomal instability.
      Title: RECQL, a member of the RecQ family of DNA helicases, suppresses chromosomal instability.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3'-5' DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3'-5' DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA/DNA annealing activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables double-stranded DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables four-way junction helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA unwinding involved in DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in replication fork processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ATP-dependent DNA helicase Q1
    Names
    DNA 3'-5' helicase Q1
    DNA-dependent ATPase Q1
    recQ protein-like 1
    NP_001191835.1
    NP_001191836.1
    NP_001342440.1
    NP_001397234.1
    NP_001397235.1
    NP_001397236.1
    NP_001397237.1
    NP_001397238.1
    NP_075529.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001204906.2 → NP_001191835.1  ATP-dependent DNA helicase Q1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and uses an alternate splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC102125, AC142413
      Consensus CDS
      CCDS57466.1
      UniProtKB/TrEMBL
      E9Q3N0, Q3UFL0
      Related
      ENSMUSP00000098394.4, ENSMUST00000100832.10
      Conserved Domains (5) summary
      TIGR00614
      Location:81 → 543
      recQ_fam; ATP-dependent DNA helicase, RecQ family
      cd00079
      Location:285 → 417
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      pfam00270
      Location:93 → 268
      DEAD; DEAD/DEAH box helicase
      pfam16124
      Location:422 → 478
      RecQ_Zn_bind; RecQ zinc-binding
      cl09632
      Location:484 → 576
      RQC; RQC domain

    2. NM_001204907.2 → NP_001191836.1  ATP-dependent DNA helicase Q1 isoform 3

      See identical proteins and their annotated locations for NP_001191836.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and uses an alternate splice site in the 3' coding region, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1. Variants 3 and 9 both encode the same isoform (3).
      Source sequence(s)
      AC102125, AC142413
      Consensus CDS
      CCDS57465.1
      UniProtKB/TrEMBL
      Q3UFL0, Q3UUK0
      Related
      ENSMUSP00000032370.7, ENSMUST00000032370.13
      Conserved Domains (1) summary
      TIGR00614
      Location:81 → 543
      recQ_fam; ATP-dependent DNA helicase, RecQ family

    3. NM_001355511.2 → NP_001342440.1  ATP-dependent DNA helicase Q1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1, and encodes isoform 1. Variants 1 and 4 encode the same protein (isoform 1).
      Source sequence(s)
      AC102125, AC142413
      Consensus CDS
      CCDS39695.1
      UniProtKB/Swiss-Prot
      Q3TPI5, Q9Z128, Q9Z129
      UniProtKB/TrEMBL
      Q91YU1
      Conserved Domains (1) summary
      TIGR00614
      Location:81 → 543
      recQ_fam; ATP-dependent DNA helicase, RecQ family

    4. NM_001410305.1 → NP_001397234.1  ATP-dependent DNA helicase Q1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC102125, AC142413
      UniProtKB/Swiss-Prot
      Q3TPI5, Q9Z128, Q9Z129

    5. NM_001410306.1 → NP_001397235.1  ATP-dependent DNA helicase Q1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC102125, AC142413

    6. NM_001410307.1 → NP_001397236.1  ATP-dependent DNA helicase Q1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC102125, AC142413

    7. NM_001410308.1 → NP_001397237.1  ATP-dependent DNA helicase Q1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC102125, AC142413

    8. NM_001410309.1 → NP_001397238.1  ATP-dependent DNA helicase Q1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC102125, AC142413
      UniProtKB/TrEMBL
      Q3UUK0

    9. NM_023042.4 → NP_075529.2  ATP-dependent DNA helicase Q1 isoform 1

      See identical proteins and their annotated locations for NP_075529.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1, 4, and 5 all encode the same isoform (1).
      Source sequence(s)
      AC102125, AC142413
      Consensus CDS
      CCDS39695.1
      UniProtKB/Swiss-Prot
      Q3TPI5, Q9Z128, Q9Z129
      UniProtKB/TrEMBL
      Q91YU1
      Related
      ENSMUSP00000107434.3, ENSMUST00000111803.9
      Conserved Domains (1) summary
      TIGR00614
      Location:81 → 543
      recQ_fam; ATP-dependent DNA helicase, RecQ family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      142296068..142332802 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z129.2 GenPept UniProtKB/Swiss-Prot:Q9Z129

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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