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    Bach2 BTB and CNC homology, basic leucine zipper transcription factor 2 [ Mus musculus (house mouse) ]

    Gene ID: 12014, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Bach2provided by MGI
    Official Full Name
    BTB and CNC homology, basic leucine zipper transcription factor 2provided by MGI
    Primary source
    MGI:MGI:894679
    See related
    Ensembl:ENSMUSG00000040270 AllianceGenome:MGI:894679
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    E030004N02Rik
    Summary
    Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in import into nucleus and negative regulation of transcription by RNA polymerase II. Acts upstream of or within regulation of transcription, DNA-templated. Located in nucleus. Is expressed in several structures, including central nervous system; limb bud; reproductive system; retina; and urinary system. Human ortholog(s) of this gene implicated in immunodeficiency 60. Orthologous to human BACH2 (BTB domain and CNC homolog 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in whole brain E14.5 (RPKM 5.3), CNS E14 (RPKM 5.0) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Bach2 in Genome Data Viewer
    Location:
    4 A5; 4 14.02 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (32238413..32586109)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (32238413..32586109)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E4615 Neighboring gene STARR-positive B cell enhancer ABC_E7959 Neighboring gene nuclear encoded tRNA glycine 3 (anticodon CCC) Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:32345161-32345344 Neighboring gene VISTA enhancer mm720 Neighboring gene STARR-positive B cell enhancer ABC_E7960 Neighboring gene STARR-positive B cell enhancer ABC_E11713 Neighboring gene STARR-positive B cell enhancer ABC_E6157 Neighboring gene STARR-positive B cell enhancer ABC_E1639 Neighboring gene STARR-positive B cell enhancer mm9_chr4:32478184-32478485 Neighboring gene STARR-seq mESC enhancer starr_09864 Neighboring gene VISTA enhancer mm510 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:32647355-32647538 Neighboring gene STARR-seq mESC enhancer starr_09865 Neighboring gene STARR-positive B cell enhancer ABC_E6158 Neighboring gene BTB and CNC homology 2, opposite strand Neighboring gene STARR-seq mESC enhancer starr_09866 Neighboring gene gap junction protein, alpha 10 Neighboring gene caspase 8 associated protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Super-killer CTLs are generated by single gene deletion of Bach2. Barton PR, et al. Eur J Immunol, 2022 Nov. PMID 36086884, Free PMC Article
    2. BACH2 in TRegs Limits the Number of Adipose Tissue Regulatory T Cells and Restrains Type 2 Immunity to Fungal Allergens. Contreras A, et al. J Immunol Res, 2022. PMID 36033397, Free PMC Article
    3. Bach2 regulates B cell survival to maintain germinal centers and promote B cell memory. Hu Q, et al. Biochem Biophys Res Commun, 2022 Aug 27. PMID 35716600
    4. Prioritization of autoimmune disease-associated genetic variants that perturb regulatory element activity in T cells. Mouri K, et al. Nat Genet, 2022 May. PMID 35513721, Free PMC Article
    5. Continuous Culture of Mouse Primary B Lymphocytes by Forced Expression of Bach2. Finney J, et al. J Immunol, 2021 Sep 1. PMID 34389622, Free PMC Article

    See all (94) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cutting Edge: Bach2 Integrates Cytokine Signals to Arbitrate Differentiation Decisions between T Follicular Helper and Th17 Lineages.
      Title: Cutting Edge: Bach2 Integrates Cytokine Signals to Arbitrate Differentiation Decisions between T Follicular Helper and Th17 Lineages.
    2. Super-killer CTLs are generated by single gene deletion of Bach2.
      Title: Super-killer CTLs are generated by single gene deletion of Bach2.
    3. The transcription factor Bach2 negatively regulates murine natural killer cell maturation and function.
      Title: The transcription factor Bach2 negatively regulates murine natural killer cell maturation and function.
    4. BACH2 in TRegs Limits the Number of Adipose Tissue Regulatory T Cells and Restrains Type 2 Immunity to Fungal Allergens.
      Title: BACH2 in TRegs Limits the Number of Adipose Tissue Regulatory T Cells and Restrains Type 2 Immunity to Fungal Allergens.
    5. Bach2 regulates B cell survival to maintain germinal centers and promote B cell memory.
      Title: Bach2 regulates B cell survival to maintain germinal centers and promote B cell memory.
    6. Bach2 Deficiency Promotes Intestinal Epithelial Regeneration by Accelerating DNA Repair in Intestinal Stem Cells.
      Title: Bach2 Deficiency Promotes Intestinal Epithelial Regeneration by Accelerating DNA Repair in Intestinal Stem Cells.
    7. Continuous Culture of Mouse Primary B Lymphocytes by Forced Expression of Bach2.
      Title: Continuous Culture of Mouse Primary B Lymphocytes by Forced Expression of Bach2.
    8. BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8(+) T cells.
      Title: BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8(+) T cells.
    9. BACH2 drives quiescence and maintenance of resting Treg cells to promote homeostasis and cancer immunosuppression.
      Title: BACH2 drives quiescence and maintenance of resting Treg cells to promote homeostasis and cancer immunosuppression.
    10. Bach2 Deficiency Leads to Spontaneous Expansion of IL-4-Producing T Follicular Helper Cells and Autoimmunity.
      Title: Bach2 Deficiency Leads to Spontaneous Expansion of IL-4-Producing T Follicular Helper Cells and Autoimmunity.
    Submit: New GeneRIF Correction See all GeneRIFs (52)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC117590

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ion binding EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in primary adaptive immune response involving T cells and B cells ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transcription regulator protein BACH2
    Names
    BTB and CNC homolog 2
    BTB and CNC homology 2
    Transcription regulator protein BACH2 (BTB and CNC homolog 2)

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109661.1 → NP_001103131.1  transcription regulator protein BACH2

      See identical proteins and their annotated locations for NP_001103131.1

      Status: VALIDATED

      Source sequence(s)
      AL831746, BC131642, CX200493
      Consensus CDS
      CCDS51135.1
      UniProtKB/Swiss-Prot
      A2ANU8, A2ANU9, A2RRI0, P97303
      Related
      ENSMUSP00000131592.2, ENSMUST00000171600.2
      Conserved Domains (2) summary
      cd14719
      Location:639 → 709
      bZIP_BACH; Basic leucine zipper (bZIP) domain of BTB and CNC homolog (BACH) proteins: a DNA-binding and dimerization domain
      cd18278
      Location:6 → 129
      BTB_POZ_BACH2; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      32238413..32586109
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011249909.3 → XP_011248211.1  transcription regulator protein BACH2 isoform X2

      See identical proteins and their annotated locations for XP_011248211.1

      UniProtKB/Swiss-Prot
      A2ANU8, A2ANU9, A2RRI0, P97303
      Related
      ENSMUSP00000103815.3, ENSMUST00000108180.9
      Conserved Domains (2) summary
      cd14719
      Location:639 → 709
      bZIP_BACH; Basic leucine zipper (bZIP) domain of BTB and CNC homolog (BACH) proteins: a DNA-binding and dimerization domain
      cd18278
      Location:6 → 129
      BTB_POZ_BACH2; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2)

    2. XM_030253112.2 → XP_030108972.1  transcription regulator protein BACH2 isoform X2

      UniProtKB/Swiss-Prot
      A2ANU8, A2ANU9, A2RRI0, P97303
      Conserved Domains (2) summary
      cd14719
      Location:639 → 709
      bZIP_BACH; Basic leucine zipper (bZIP) domain of BTB and CNC homolog (BACH) proteins: a DNA-binding and dimerization domain
      cd18278
      Location:6 → 129
      BTB_POZ_BACH2; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2)

    3. XM_011249908.4 → XP_011248210.1  transcription regulator protein BACH2 isoform X1

      See identical proteins and their annotated locations for XP_011248210.1

      Conserved Domains (2) summary
      cd14719
      Location:646 → 716
      bZIP_BACH; Basic leucine zipper (bZIP) domain of BTB and CNC homolog (BACH) proteins: a DNA-binding and dimerization domain
      cd18278
      Location:13 → 136
      BTB_POZ_BACH2; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2)

    4. XM_006537566.5 → XP_006537629.1  transcription regulator protein BACH2 isoform X1

      See identical proteins and their annotated locations for XP_006537629.1

      Conserved Domains (2) summary
      cd14719
      Location:646 → 716
      bZIP_BACH; Basic leucine zipper (bZIP) domain of BTB and CNC homolog (BACH) proteins: a DNA-binding and dimerization domain
      cd18278
      Location:13 → 136
      BTB_POZ_BACH2; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2)

    5. XM_030253109.2 → XP_030108969.1  transcription regulator protein BACH2 isoform X1

      Conserved Domains (2) summary
      cd14719
      Location:646 → 716
      bZIP_BACH; Basic leucine zipper (bZIP) domain of BTB and CNC homolog (BACH) proteins: a DNA-binding and dimerization domain
      cd18278
      Location:13 → 136
      BTB_POZ_BACH2; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2)

    6. XM_036163607.1 → XP_036019500.1  transcription regulator protein BACH2 isoform X2

      UniProtKB/Swiss-Prot
      A2ANU8, A2ANU9, A2RRI0, P97303
      Conserved Domains (2) summary
      cd14719
      Location:639 → 709
      bZIP_BACH; Basic leucine zipper (bZIP) domain of BTB and CNC homolog (BACH) proteins: a DNA-binding and dimerization domain
      cd18278
      Location:6 → 129
      BTB_POZ_BACH2; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2)

    7. XM_036163608.1 → XP_036019501.1  transcription regulator protein BACH2 isoform X2

      UniProtKB/Swiss-Prot
      A2ANU8, A2ANU9, A2RRI0, P97303
      Conserved Domains (2) summary
      cd14719
      Location:639 → 709
      bZIP_BACH; Basic leucine zipper (bZIP) domain of BTB and CNC homolog (BACH) proteins: a DNA-binding and dimerization domain
      cd18278
      Location:6 → 129
      BTB_POZ_BACH2; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2)

    8. XM_006537567.5 → XP_006537630.1  transcription regulator protein BACH2 isoform X2

      See identical proteins and their annotated locations for XP_006537630.1

      UniProtKB/Swiss-Prot
      A2ANU8, A2ANU9, A2RRI0, P97303
      Conserved Domains (2) summary
      cd14719
      Location:639 → 709
      bZIP_BACH; Basic leucine zipper (bZIP) domain of BTB and CNC homolog (BACH) proteins: a DNA-binding and dimerization domain
      cd18278
      Location:6 → 129
      BTB_POZ_BACH2; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2)

    9. XM_011249910.4 → XP_011248212.1  transcription regulator protein BACH2 isoform X3

      Conserved Domains (1) summary
      cd14719
      Location:522 → 592
      bZIP_BACH; Basic leucine zipper (bZIP) domain of BTB and CNC homolog (BACH) proteins: a DNA-binding and dimerization domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_007521.3: Suppressed sequence

      Description
      NM_007521.3: This RefSeq was permanently suppressed because it represents a poorly supported variant with non-consensus splice sites.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P97303.3 GenPept UniProtKB/Swiss-Prot:P97303

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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