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    Ankhd1 ankyrin repeat and KH domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 108857, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Ankhd1provided by MGI
    Official Full Name
    ankyrin repeat and KH domain containing 1provided by MGI
    Primary source
    MGI:MGI:1921733
    See related
    Ensembl:ENSMUSG00000024483 AllianceGenome:MGI:1921733
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mask; mFLJ00246; mKIAA1085; 1110004O12Rik; 4933432B13Rik; 9130019P20Rik; A530027J04Rik; A630021B20Rik
    Summary
    Predicted to be involved in innate immune response. Predicted to be active in cytoplasm. Is expressed in blastocyst; brain; and spinal cord. Orthologous to several human genes including ANKHD1-EIF4EBP3 (ANKHD1-EIF4EBP3 readthrough). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thymus adult (RPKM 13.2), limb E14.5 (RPKM 11.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    18 B2; 18 19.46 cM
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (36693656..36791961)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (36560603..36658908)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_44290 Neighboring gene heparin-binding EGF-like growth factor Neighboring gene predicted gene, 41698 Neighboring gene solute carrier family 4, sodium bicarbonate cotransporter, member 9 Neighboring gene STARR-seq mESC enhancer starr_44296 Neighboring gene proteasome (prosome, macropain) subunit, alpha type 4 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E5653 Neighboring gene eukaryotic translation initiation factor 4E binding protein 3 Neighboring gene steroid receptor RNA activator 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mask family proteins ANKHD1 and ANKRD17 regulate YAP nuclear import and stability. Sidor C, et al. Elife, 2019 Oct 29. PMID 31661072, Free PMC Article
    2. Gene fusion and overlapping reading frames in the mammalian genes for 4E-BP3 and MASK. Poulin F, et al. J Biol Chem, 2003 Dec 26. PMID 14557257
    3. Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDnas identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Apr 30. PMID 15449545
    4. Transcription factors expressed in olfactory bulb local progenitor cells revealed by genome-wide transcriptome profiling. Campbell GR, et al. Mol Cell Neurosci, 2011 Feb. PMID 21194568, Free PMC Article
    5. High-throughput screen for genes predominantly expressed in the ICM of mouse blastocysts by whole mount in situ hybridization. Yoshikawa T, et al. Gene Expr Patterns, 2006 Jan. PMID 16325481, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Readthrough Maskbp3

    Readthrough gene: Maskbp3, Included gene: Eif4ebp3

    Homology

    Clone Names

    • FLJ00246

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin repeat and KH domain-containing protein 1
    Names
    multiple ankyrin repeats, single KH-domain homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175375.3 → NP_780584.2  ankyrin repeat and KH domain-containing protein 1

      Status: VALIDATED

      Source sequence(s)
      AC115631, AK029322, AK042754, BC091647, BG804884, CD538664, CF742822, CJ165547
      Consensus CDS
      CCDS50256.1
      UniProtKB/TrEMBL
      E9PUR0, E9Q1M6
      Related
      ENSMUSP00000123270.3, ENSMUST00000155329.9
      Conserved Domains (7) summary
      cd00105
      Location:1696 → 1758
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      cd00204
      Location:370 → 494
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam05672
      Location:783 → 870
      MAP7; MAP7 (E-MAP-115) family
      pfam12796
      Location:279 → 368
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:377 → 428
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:409 → 438
      ANK; ANK repeat [structural motif]
      cl09111
      Location:817 → 855
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      36693656..36791961
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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