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    Mindy1 MINDY lysine 48 deubiquitinase 1 [ Mus musculus (house mouse) ]

    Gene ID: 75007, updated on 23-Jun-2021

    Summary

    Official Symbol
    Mindy1provided by MGI
    Official Full Name
    MINDY lysine 48 deubiquitinase 1provided by MGI
    Primary source
    MGI:MGI:1922257
    See related
    Ensembl:ENSMUSG00000038712
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ni; Fam6; cI-4; cI-40; Fam63a; AA562754; AA960384; AW561904; mKIAA1390; 1810005H09Rik; 4930504E06Rik
    Expression
    Ubiquitous expression in adrenal adult (RPKM 42.0), ovary adult (RPKM 32.3) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Mindy1 in Genome Data Viewer
    Location:
    3; 3 F2.1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (95189237..95203477)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (95281926..95296166)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (95086866..95100083)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11 Neighboring gene CDC42 small effector 1 Neighboring gene predicted gene 128 Neighboring gene BCL2/adenovirus E1B 19kD interacting protein like Neighboring gene prune exopolyphosphatase Neighboring gene annexin A9 Neighboring gene uncharacterized LOC115489748 Neighboring gene ceramide synthase 2 Neighboring gene SET domain, bifurcated 1 Neighboring gene predicted gene, 37500

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables K48-linked polyubiquitin modification-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables Lys48-specific deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables Lys48-specific deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cysteine-type carboxypeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables cysteine-type carboxypeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables thiol-dependent deubiquitinase IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in protein K48-linked deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cell periphery IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ubiquitin carboxyl-terminal hydrolase MINDY-1
    Names
    NF-E2 inducible protein
    deubiquitinating enzyme MINDY-1
    family with sequence similarity 63, member A
    protein FAM63A
    NP_598619.2
    NP_955769.1
    XP_006502282.1
    XP_011238563.1
    XP_030108719.1
    XP_030108720.1
    XP_036019260.1
    XP_036019261.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133858.4NP_598619.2  ubiquitin carboxyl-terminal hydrolase MINDY-1 isoform 2

      See identical proteins and their annotated locations for NP_598619.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.
      Source sequence(s)
      AK036838, BC094388, BQ571591
      Consensus CDS
      CCDS17611.1
      UniProtKB/Swiss-Prot
      Q76LS9
      Related
      ENSMUSP00000043910.8, ENSMUST00000039537.14
      Conserved Domains (1) summary
      pfam04424
      Location:144261
      DUF544; Protein of unknown function (DUF544)
    2. NM_199475.1NP_955769.1  ubiquitin carboxyl-terminal hydrolase MINDY-1 isoform 1

      See identical proteins and their annotated locations for NP_955769.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC094388, BC132301, BQ571591
      Consensus CDS
      CCDS57233.1
      UniProtKB/Swiss-Prot
      Q76LS9
      UniProtKB/TrEMBL
      B7ZMR0
      Related
      ENSMUSP00000102805.3, ENSMUST00000107187.9
      Conserved Domains (1) summary
      pfam04424
      Location:144261
      MINDY_DUB; MINDY deubiquitinase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      95189237..95203477
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006502219.4XP_006502282.1  ubiquitin carboxyl-terminal hydrolase MINDY-1 isoform X1

      See identical proteins and their annotated locations for XP_006502282.1

      UniProtKB/Swiss-Prot
      Q76LS9
      UniProtKB/TrEMBL
      B7ZMR0
      Conserved Domains (1) summary
      pfam04424
      Location:144261
      MINDY_DUB; MINDY deubiquitinase
    2. XM_036163368.1XP_036019261.1  ubiquitin carboxyl-terminal hydrolase MINDY-1 isoform X2

      Conserved Domains (1) summary
      pfam04424
      Location:164
      MINDY_DUB; MINDY deubiquitinase
    3. XM_036163367.1XP_036019260.1  ubiquitin carboxyl-terminal hydrolase MINDY-1 isoform X1

      Conserved Domains (1) summary
      pfam04424
      Location:144261
      MINDY_DUB; MINDY deubiquitinase
    4. XM_030252859.2XP_030108719.1  ubiquitin carboxyl-terminal hydrolase MINDY-1 isoform X2

      Conserved Domains (1) summary
      pfam04424
      Location:164
      MINDY_DUB; MINDY deubiquitinase
    5. XM_011240261.3XP_011238563.1  ubiquitin carboxyl-terminal hydrolase MINDY-1 isoform X2

      See identical proteins and their annotated locations for XP_011238563.1

      Conserved Domains (1) summary
      pfam04424
      Location:164
      MINDY_DUB; MINDY deubiquitinase
    6. XM_030252860.1XP_030108720.1  ubiquitin carboxyl-terminal hydrolase MINDY-1 isoform X3

      Conserved Domains (1) summary
      pfam04424
      Location:164
      MINDY_DUB; MINDY deubiquitinase
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