Snx5 sorting nexin 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Snx5provided by MGI
Official Full Name: sorting nexin 5provided by MGI
Primary source: MGI:MGI:1916428
See related: Ensembl:ENSMUSG00000027423 AllianceGenome:MGI:1916428
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: D2Ertd52e; 0910001N05Rik; 1810032P22Rik
Summary: Predicted to enable D1 dopamine receptor binding activity; dynactin binding activity; and phosphatidylinositol phosphate binding activity. Predicted to be involved in several processes, including positive regulation of renal sodium excretion; regulation of signal transduction; and retrograde transport, endosome to Golgi. Predicted to act upstream of or within endocytosis and protein transport. Predicted to be located in several cellular components, including brush border; macropinocytic cup; and tubular endosome. Predicted to be extrinsic component of cytoplasmic side of plasma membrane and extrinsic component of endosome membrane. Predicted to be part of retromer complex. Predicted to be active in endosome. Predicted to colocalize with early endosome membrane. Is expressed in several structures, including alimentary system; brain; cranium; genitourinary system; and sensory organ. Orthologous to human SNX5 (sorting nexin 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in placenta adult (RPKM 42.1), liver E14 (RPKM 37.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 G1; 2 70.98 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (144092043..144112713, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (144250123..144270902, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sorting nexin-5 is not required for normal spermatogenesis and male fertilization in mice.
Title: Sorting nexin-5 is not required for normal spermatogenesis and male fertilization in mice.
Sorting nexin 5 mediates virus-induced autophagy and immunity.
Title: Sorting nexin 5 mediates virus-induced autophagy and immunity.
Finally, Chlamydia trachomatis infection interferes with the SNX5:cation-independent mannose-6-phosphate receptor interaction, suggesting that Chlamydia IncE and cation-independent mannose-6-phosphate receptor are dependent on the same binding surface on SNX5.
Title: Chlamydia interfere with an interaction between the mannose-6-phosphate receptor and sorting nexins to counteract host restriction.
thyroid cancer model using carcinogen and an anti-thyroidal agent revealed that Snx5(-/-) mice developed metastasizing thyroid tumors with activation of MAP kinase and AKT pathways
Title: Loss of sorting nexin 5 stabilizes internalized growth factor receptors to promote thyroid cancer progression.
findings reveal the important contribution of dorsal ruffing to receptor-activated macropinocytosis in primary macrophages and show that SNX5 selectively regulates macropinosomes derived from the dorsal ruffles.
Title: Sorting nexin 5 selectively regulates dorsal-ruffle-mediated macropinocytosis in primary macrophages.
Histological analysis revealed that Snx5(-/-) mice exhibited thickened alveolar walls associated with undifferentiated alveolar epithelial type I cells. In contrast, type II cells were intact, exhibiting normal surfactant synthesis and secretion.
Title: Disruption of sorting nexin 5 causes respiratory failure associated with undifferentiated alveolar epithelial type I cells in mice.
Data indicate high expression of sorting nexin 5 (Snx5) in chemically induced papillary thyroid carcinoma.
Title: Sorting nexin 5 of a new diagnostic marker of papillary thyroid carcinoma regulates Caspase-2.
SNX5 requires the generation of phosphoinositides for recruitment to the plasma membrane and, moreover, influences the level of macropinocytic activity
Title: A role for SNX5 in the regulation of macropinocytosis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH140677 (e-PCR)
- UniSTS:222745

D2Ertd52e (e-PCR), detects polymorphism
- UniSTS:167329

AA851347 (e-PCR)
- UniSTS:243367

RH136412 (e-PCR)
- UniSTS:210402

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables D1 dopamine receptor binding	ISO Inferred from Sequence Orthology more info
enables dynactin binding	IBA Inferred from Biological aspect of Ancestor more info
enables dynactin binding	ISO Inferred from Sequence Orthology more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3,5-bisphosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-4-phosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-5-phosphate binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within endocytosis	IEA Inferred from Electronic Annotation more info
involved_in epidermal growth factor catabolic process	ISO Inferred from Sequence Orthology more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in pinocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in pinocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
involved_in retrograde transport, endosome to Golgi	IBA Inferred from Biological aspect of Ancestor more info
involved_in retrograde transport, endosome to Golgi	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in brush border	ISO Inferred from Sequence Orthology more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic side of early endosome membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in macropinocytic cup	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of retromer complex	ISO Inferred from Sequence Orthology more info
located_in tubular endosome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sorting nexin-5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001199188.2 → NP_001186117.1 sorting nexin-5

See identical proteins and their annotated locations for NP_001186117.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.

Source sequence(s)

AL808123, AL824710

Consensus CDS

CCDS16815.1

UniProtKB/Swiss-Prot

Q543N9, Q9D8U8

UniProtKB/TrEMBL

Q3TJN6, Q8C5E7

Related

ENSMUSP00000105657.4, ENSMUST00000110030.10

Conserved Domains (2) summary

cd07663
Location:185 → 402

BAR_SNX5; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 5

cl02563
Location:29 → 169

PX_domain; The Phox Homology domain, a phosphoinositide binding module
NM_024225.6 → NP_077187.1 sorting nexin-5

See identical proteins and their annotated locations for NP_077187.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

AL808123, AL824710

Consensus CDS

CCDS16815.1

UniProtKB/Swiss-Prot

Q543N9, Q9D8U8

UniProtKB/TrEMBL

Q3TJN6, Q8C5E7

Related

ENSMUSP00000028909.5, ENSMUST00000028909.5

Conserved Domains (2) summary

cd07663
Location:185 → 402

BAR_SNX5; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 5

cl02563
Location:29 → 169

PX_domain; The Phox Homology domain, a phosphoinositide binding module