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    Rnps1 RNA binding protein with serine rich domain 1 [ Mus musculus (house mouse) ]

    Gene ID: 19826, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Rnps1provided by MGI
    Official Full Name
    RNA binding protein with serine rich domain 1provided by MGI
    Primary source
    MGI:MGI:97960
    See related
    Ensembl:ENSMUSG00000034681 AllianceGenome:MGI:97960
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable mRNA 3'-UTR binding activity. Predicted to be involved in mRNA metabolic process; positive regulation of apoptotic process; and regulation of mRNA splicing, via spliceosome. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be located in nucleus. Predicted to be part of ASAP complex. Predicted to be active in cytoplasm and nucleoplasm. Is expressed in central nervous system; sensory organ; thymus; and tooth. Orthologous to human RNPS1 (RNA binding protein with serine rich domain 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 88.5), CNS E14 (RPKM 86.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rnps1 in Genome Data Viewer
    Location:
    17 A3.3; 17 12.39 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (24633620..24644872)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (24414646..24425898)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene ATP-binding cassette, sub-family A member 3 Neighboring gene predicted gene, 25618 Neighboring gene STARR-seq mESC enhancer starr_42084 Neighboring gene RIKEN cDNA D330041H03 gene Neighboring gene STARR-positive B cell enhancer ABC_E3188 Neighboring gene enoyl-Coenzyme A delta isomerase 1 Neighboring gene deoxyribonuclease 1-like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. RNPS1 inhibits excessive tumor necrosis factor/tumor necrosis factor receptor signaling to support hematopoiesis in mice. Zhong X, et al. Proc Natl Acad Sci U S A, 2022 May 3. PMID 35482923, Free PMC Article
    2. RNPS1 inhibition aggravates ischemic brain injury and promotes neuronal death. Zhang Z, et al. Biochem Biophys Res Commun, 2020 Feb 26. PMID 31831174
    3. Cell type-specific expression of hnRNP proteins. Kamma H, et al. Exp Cell Res, 1995 Nov. PMID 7589244
    4. Sequence of a complete murine cDNA reflecting an S phase-prevalent transcript encoding a protein with two types of nucleic acid binding motifs. Schmidt G, et al. Biochim Biophys Acta, 1993 Nov 16. PMID 8241277
    5. Exon Junction Complex Shapes the Transcriptome by Repressing Recursive Splicing. Blazquez L, et al. Mol Cell, 2018 Nov 1. PMID 30388411, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RNPS1 inhibits excessive tumor necrosis factor/tumor necrosis factor receptor signaling to support hematopoiesis in mice.
      Title: RNPS1 inhibits excessive tumor necrosis factor/tumor necrosis factor receptor signaling to support hematopoiesis in mice.
    2. RNPS1 inhibition aggravates ischemic brain injury and promotes neuronal death.
      Title: RNPS1 inhibition aggravates ischemic brain injury and promotes neuronal death.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA 3'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of ASAP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ASAP complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    RNA-binding protein with serine-rich domain 1
    Names
    ribonucleic acid binding protein S1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080127.1 → NP_001073596.1  RNA-binding protein with serine-rich domain 1 isoform 1

      See identical proteins and their annotated locations for NP_001073596.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an internal exon in the 5' UTR, compared to variant 1. Variants 1, 2 and 4 encode the same isoform (1).
      Source sequence(s)
      AK151150, BX526195, CJ058744
      Consensus CDS
      CCDS37488.1
      UniProtKB/Swiss-Prot
      Q3TMJ1, Q922H8, Q99M28
      Related
      ENSMUSP00000085867.6, ENSMUST00000088512.13
      Conserved Domains (1) summary
      cd12365
      Location:163 → 236
      RRM_RNPS1; RNA recognition motif (RRM) found in RNA-binding protein with serine-rich domain 1 (RNPS1) and similar proteins

    2. NM_001080128.1 → NP_001073597.1  RNA-binding protein with serine-rich domain 1 isoform 2

      See identical proteins and their annotated locations for NP_001073597.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two consecutive exons in the 5' region, which results in an alternate translation start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK165905, BX526195, BY013195
      Consensus CDS
      CCDS37487.1
      UniProtKB/Swiss-Prot
      Q99M28
      Related
      ENSMUSP00000111028.2, ENSMUST00000115371.9
      Conserved Domains (1) summary
      cd12365
      Location:140 → 213
      RRM_RNPS1; RNA recognition motif (RRM) found in RNA-binding protein with serine-rich domain 1 (RNPS1) and similar proteins

    3. NM_001357626.1 → NP_001344555.1  RNA-binding protein with serine-rich domain 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 4 encode the same isoform (1).
      Source sequence(s)
      AC154237, BQ174147
      Consensus CDS
      CCDS37488.1
      UniProtKB/Swiss-Prot
      Q3TMJ1, Q922H8, Q99M28
      Conserved Domains (1) summary
      cd12365
      Location:163 → 236
      RRM_RNPS1; RNA recognition motif (RRM) found in RNA-binding protein with serine-rich domain 1 (RNPS1) and similar proteins

    4. NM_009070.2 → NP_033096.2  RNA-binding protein with serine-rich domain 1 isoform 1

      See identical proteins and their annotated locations for NP_033096.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1, 2 and 4 encode the same isoform (1).
      Source sequence(s)
      AK151150, BB868062, BX526195
      Consensus CDS
      CCDS37488.1
      UniProtKB/Swiss-Prot
      Q3TMJ1, Q922H8, Q99M28
      Related
      ENSMUSP00000126345.2, ENSMUST00000163717.2
      Conserved Domains (1) summary
      cd12365
      Location:163 → 236
      RRM_RNPS1; RNA recognition motif (RRM) found in RNA-binding protein with serine-rich domain 1 (RNPS1) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      24633620..24644872
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99M28.1 GenPept UniProtKB/Swiss-Prot:Q99M28

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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