Sgo2a shugoshin 2A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sgo2aprovided by MGI
Official Full Name: shugoshin 2Aprovided by MGI
Primary source: MGI:MGI:1098767
See related: Ensembl:ENSMUSG00000026039 AllianceGenome:MGI:1098767
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Sgol2; Sgol2a; Tripin; D1Ertd8e; 1110007N04Rik; 4932411A20Rik; 5730576N04Rik
Summary: Acts upstream of or within meiotic nuclear division; positive regulation of maintenance of meiotic sister chromatid cohesion, centromeric; and protein localization. Located in kinetochore. Is expressed in nervous system and oocyte. Orthologous to human SGO2 (shugoshin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in CNS E11.5 (RPKM 7.1), placenta adult (RPKM 4.8) and 12 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 1 C1.3; 1 28.86 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (58024499..58065436)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (57985340..58026277)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

By promoting proteolysis of cyclins and Cdc25B at germinal vesicle stage, APC/C associated Cdh1(APC/CCdh1) delays increase in Cdk1 activity, leading to germinal vesicle breakdown (GVBD); by moderating the rate at which Cdk1 is activated following GVBD, APC/CCdh1 creates conditions necessary for the removal of shugoshin-2 from chromosome arms by Aurora B/C kinase, an event crucial for efficient resolution of chiasmata.
Title: APC/C(Cdh1) Enables Removal of Shugoshin-2 from the Arms of Bivalent Chromosomes by Moderating Cyclin-Dependent Kinase Activity.
Molecular chaperone SET-assisted eviction of linker histones and Shugoshins is a fundamental step in mammalian mitotic progression.
Title: Phospho-H1 Decorates the Inter-chromatid Axis and Is Evicted along with Shugoshin by SET during Mitosis.
In mouse, Sgol2a encoding shugoshin-like 2a is necessary during meiosis in both sexes to maintain the integrity of the cohesin complex that tethers sister chromatids. Human SGO2 has not previously been implicated in any disorder, but in this case of POI and perhaps others, it is a candidate for unexplained infertility.
Title: Mutations of SGO2 and CLDN14 collectively cause coincidental Perrault syndrome.
Sgo2 localizes at the subtelomeres preferentially during G2 phase and is essential for the formation of a highly condensed subtelomeric chromatin body 'knob'.
Title: Shugoshin forms a specialized chromatin domain at subtelomeres that regulates transcription and replication timing.
Shugoshin 2 is necessary for the loading of MCAK at the inner centromere, but is dispensable for the loading of the outer kinetochore proteins BubR1 and CENP-E.
Title: Sequential assembly of centromeric proteins in male mouse meiosis.
SGOL2 is necessary for protecting centromeric cohesion during mammalian meiosis I. In vivo, the loss of SGOL2 promotes a premature release of the meiosis-specific REC8 cohesin complexes from anaphase I centromeres
Title: Shugoshin-2 is essential for the completion of meiosis but not for mitotic cell division in mice.
Results show that shugoshin Sgo2 is expressed in germ cells.
Title: Unified mode of centromeric protection by shugoshin in mammalian oocytes and somatic cells.

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1) 1 citation
Endonuclease-mediated (1)
Targeted (1)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

Sgol2 (e-PCR), detects polymorphism
- UniSTS:546564

15.MMHAP26FLE3.seq (e-PCR)
- UniSTS:123256

D1Ertd8e (e-PCR), detects polymorphism
- UniSTS:167300

NoName (e-PCR)
- UniSTS:234132

AV008062 (e-PCR)
- UniSTS:165079

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chromosome segregation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within female meiotic nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of maintenance of meiotic sister chromatid cohesion, centromeric	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within male meiotic nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in meiotic sister chromatid cohesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within meiotic sister chromatid cohesion involved in meiosis I	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within meiotic sister chromatid cohesion, centromeric	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of maintenance of meiotic sister chromatid cohesion, centromeric	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein localization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome, centromeric region	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome, centromeric region	ISO Inferred from Sequence Orthology more info
located_in condensed chromosome, centromeric region	IDA Inferred from Direct Assay more info	PubMed
is_active_in kinetochore	IBA Inferred from Biological aspect of Ancestor more info
located_in kinetochore	IDA Inferred from Direct Assay more info	PubMed
part_of mitotic cohesin complex	ISO Inferred from Sequence Orthology more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: shugoshin 2

Names: sgo2; shugoshin-like 2; shugoshin-like 2a

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001177867.1 → NP_001171338.1 shugoshin 2 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks a few of 5' exons but has an alternate 5' exon, as compared to variant 1. The resulting isoform (2) is shorter and has a different N-terminus, as compared to isoform 1.

Source sequence(s)

BC052742, CN716821

UniProtKB/Swiss-Prot

Q7TSY8

Conserved Domains (1) summary

pfam05539
Location:35 → 228

Pneumo_att_G; Pneumovirinae attachment membrane glycoprotein G
NM_199007.2 → NP_950172.1 shugoshin 2 isoform 1

See identical proteins and their annotated locations for NP_950172.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AK042448, AK138621, BC052742

Consensus CDS

CCDS35574.1

UniProtKB/Swiss-Prot

Q7TSY8, Q811I4, Q8C9C4, Q8CGJ4, Q9CS55

Related

ENSMUSP00000027202.9, ENSMUST00000027202.9

Conserved Domains (1) summary

pfam05539
Location:135 → 328

Pneumo_att_G; Pneumovirinae attachment membrane glycoprotein G