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    Dnajc14 DnaJ heat shock protein family (Hsp40) member C14 [ Mus musculus (house mouse) ]

    Gene ID: 74330, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Dnajc14provided by MGI
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member C14provided by MGI
    Primary source
    MGI:MGI:1921580
    See related
    Ensembl:ENSMUSG00000025354 AllianceGenome:MGI:1921580
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DNAJ; HDJ3; LIP6; DRIP78; 5730551F12Rik
    Summary
    Predicted to enable dopamine receptor binding activity. Predicted to act upstream of or within protein transport. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be integral component of membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Orthologous to human DNAJC14 (DnaJ heat shock protein family (Hsp40) member C14). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in placenta adult (RPKM 8.4), CNS E11.5 (RPKM 8.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    10 D3; 10 77.16 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (128641423..128655317)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (128804904..128819448)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein SA, pseudogene 2 Neighboring gene matrix metallopeptidase 19 Neighboring gene transmembrane protein 198b Neighboring gene STARR-positive B cell enhancer ABC_E1817 Neighboring gene STARR-positive B cell enhancer ABC_E74 Neighboring gene ORM1-like 2 (S. cerevisiae) Neighboring gene SAP domain containing ribonucleoprotein Neighboring gene STARR-positive B cell enhancer ABC_E10662 Neighboring gene growth differentiation factor 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Dopamine D1 receptor density in the mPFC responds to cognitive demands and receptor turnover contributes to general cognitive ability in mice. Wass C, et al. Sci Rep, 2018 Mar 14. PMID 29540721, Free PMC Article
    2. Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. Sundberg JP, et al. PLoS One, 2017. PMID 28700664, Free PMC Article
    3. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables dopamine receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dopamine receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dnaJ homolog subfamily C member 14
    Names
    DnaJ (Hsp40) homolog, subfamily C, member 14

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359824.1 → NP_001346753.1  dnaJ homolog subfamily C member 14

      Status: VALIDATED

      Source sequence(s)
      AC131081, AK017830, AK045445, AK082579, BE688094
      Consensus CDS
      CCDS24294.1
      UniProtKB/Swiss-Prot
      Q3TX73, Q8BUU3, Q921R4, Q9CYB7
      UniProtKB/TrEMBL
      Q8BLF3
      Related
      ENSMUSP00000151343.2, ENSMUST00000219508.2
      Conserved Domains (2) summary
      pfam00226
      Location:444 → 505
      DnaJ; DnaJ domain
      pfam14901
      Location:533 → 621
      Jiv90; Cleavage inducing molecular chaperone

    2. NM_001359825.1 → NP_001346754.1  dnaJ homolog subfamily C member 14

      Status: VALIDATED

      Source sequence(s)
      AC131081, AK045445, AK082579, BE688094
      Consensus CDS
      CCDS24294.1
      UniProtKB/Swiss-Prot
      Q3TX73, Q8BUU3, Q921R4, Q9CYB7
      UniProtKB/TrEMBL
      Q8BLF3
      Related
      ENSMUSP00000151530.2, ENSMUST00000217745.2
      Conserved Domains (2) summary
      pfam00226
      Location:444 → 505
      DnaJ; DnaJ domain
      pfam14901
      Location:533 → 621
      Jiv90; Cleavage inducing molecular chaperone

    3. NM_028873.5 → NP_083149.3  dnaJ homolog subfamily C member 14

      See identical proteins and their annotated locations for NP_083149.3

      Status: VALIDATED

      Source sequence(s)
      AK017830, AK082579, AK083878, BE688094
      Consensus CDS
      CCDS24294.1
      UniProtKB/Swiss-Prot
      Q3TX73, Q8BUU3, Q921R4, Q9CYB7
      UniProtKB/TrEMBL
      Q8BLF3
      Related
      ENSMUSP00000026410.2, ENSMUST00000026410.2
      Conserved Domains (2) summary
      pfam00226
      Location:444 → 505
      DnaJ; DnaJ domain
      pfam14901
      Location:533 → 621
      Jiv90; Cleavage inducing molecular chaperone

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      128641423..128655317
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q921R4.2 GenPept UniProtKB/Swiss-Prot:Q921R4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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