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    Prrt3 proline-rich transmembrane protein 3 [ Mus musculus (house mouse) ]

    Gene ID: 210673, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Prrt3provided by MGI
    Official Full Name
    proline-rich transmembrane protein 3provided by MGI
    Primary source
    MGI:MGI:2444810
    See related
    Ensembl:ENSMUSG00000045009 AllianceGenome:MGI:2444810
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6330505P20; B230206N24Rik
    Summary
    Predicted to be located in membrane. Predicted to be integral component of membrane. Orthologous to human PRRT3 (proline rich transmembrane protein 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in cortex adult (RPKM 8.5), cerebellum adult (RPKM 8.3) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    6 E3; 6 52.77 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (113470599..113479071, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (113493638..113502082, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene interleukin 17 receptor C Neighboring gene STARR-positive B cell enhancer ABC_E684 Neighboring gene STARR-seq mESC enhancer starr_17041 Neighboring gene cysteine-rich with EGF-like domains 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:113467707-113467969 Neighboring gene ER membrane protein complex subunit 3 Neighboring gene Fanconi anemia, complementation group D2 Neighboring gene predicted gene, 46971

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Pancreatic islet and progenitor cell surface markers with cell sorting potential. Hald J, et al. Diabetologia, 2012 Jan. PMID 21947380
    2. Rescue of neuropsychiatric phenotypes in a mouse model of 16p11.2 duplication syndrome by genetic correction of an epilepsy network hub. Forrest MP, et al. Nat Commun, 2023 Feb 17. PMID 36808153, Free PMC Article
    3. Comprehensive identification of phosphorylation sites in postsynaptic density preparations. Trinidad JC, et al. Mol Cell Proteomics, 2006 May. PMID 16452087
    4. Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. Munton RP, et al. Mol Cell Proteomics, 2007 Feb. PMID 17114649
    5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    proline-rich transmembrane protein 3

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289699.1 → NP_001276628.1  proline-rich transmembrane protein 3 isoform a precursor

      See identical proteins and their annotated locations for NP_001276628.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AC153910, AK031947, AK136854
      Consensus CDS
      CCDS85122.1
      UniProtKB/TrEMBL
      A0A0N4SVB5
      Related
      ENSMUSP00000145443.2, ENSMUST00000204268.3
      Conserved Domains (1) summary
      PHA03247
      Location:64 → 464
      PHA03247; large tegument protein UL36; Provisional

    2. NM_001289700.1 → NP_001276629.1  proline-rich transmembrane protein 3 isoform a precursor

      See identical proteins and their annotated locations for NP_001276629.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AC153910, AK031947, AK136854, BC058349
      Consensus CDS
      CCDS85122.1
      UniProtKB/TrEMBL
      A0A0N4SVB5
      Related
      ENSMUSP00000145031.2, ENSMUST00000204134.3
      Conserved Domains (1) summary
      PHA03247
      Location:64 → 464
      PHA03247; large tegument protein UL36; Provisional

    3. NM_172487.4 → NP_766075.2  proline-rich transmembrane protein 3 isoform b precursor

      See identical proteins and their annotated locations for NP_766075.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (b) is shorter than isoform 1.
      Source sequence(s)
      AC153910, AK136854, BC058349
      Consensus CDS
      CCDS20424.1
      UniProtKB/Swiss-Prot
      Q6PE13
      Related
      ENSMUSP00000098620.2, ENSMUST00000101059.4
      Conserved Domains (2) summary
      PHA03247
      Location:64 → 463
      PHA03247; large tegument protein UL36; Provisional
      PRK07764
      Location:273 → 447
      PRK07764; DNA polymerase III subunits gamma and tau; Validated

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      113470599..113479071 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030255299.2 → XP_030111159.1  proline-rich transmembrane protein 3 isoform X2

      UniProtKB/Swiss-Prot
      Q6PE13
      Conserved Domains (2) summary
      PHA03247
      Location:64 → 463
      PHA03247; large tegument protein UL36; Provisional
      PRK07764
      Location:273 → 447
      PRK07764; DNA polymerase III subunits gamma and tau; Validated

    2. XM_006505843.5 → XP_006505906.1  proline-rich transmembrane protein 3 isoform X2

      See identical proteins and their annotated locations for XP_006505906.1

      UniProtKB/Swiss-Prot
      Q6PE13
      Conserved Domains (2) summary
      PHA03247
      Location:64 → 463
      PHA03247; large tegument protein UL36; Provisional
      PRK07764
      Location:273 → 447
      PRK07764; DNA polymerase III subunits gamma and tau; Validated

    3. XM_011241275.2 → XP_011239577.1  proline-rich transmembrane protein 3 isoform X1

      See identical proteins and their annotated locations for XP_011239577.1

      UniProtKB/TrEMBL
      A0A0N4SVB5
      Conserved Domains (1) summary
      PHA03247
      Location:64 → 464
      PHA03247; large tegument protein UL36; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PE13.1 GenPept UniProtKB/Swiss-Prot:Q6PE13

    Gene LinkOut

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