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    Usp37 ubiquitin specific peptidase 37 [ Mus musculus (house mouse) ]

    Gene ID: 319651, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Usp37provided by MGI
    Official Full Name
    ubiquitin specific peptidase 37provided by MGI
    Primary source
    MGI:MGI:2442483
    See related
    Ensembl:ENSMUSG00000033364 AllianceGenome:MGI:2442483
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4932415L06Rik; C330008N13Rik
    Summary
    Predicted to enable cysteine-type endopeptidase activity; protein kinase binding activity; and thiol-dependent deubiquitinase. Predicted to be involved in G1/S transition of mitotic cell cycle; protein deubiquitination; and regulation of DNA replication. Predicted to act upstream of or within cell division. Predicted to be active in cytosol and nucleus. Orthologous to human USP37 (ubiquitin specific peptidase 37). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in duodenum adult (RPKM 7.5), small intestine adult (RPKM 7.5) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Usp37 in Genome Data Viewer
    Location:
    1 C3- C4; 1 38.54 cM
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (74474669..74583447, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (74435510..74544286, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:74433475-74433675 Neighboring gene STARR-positive B cell enhancer ABC_E2549 Neighboring gene solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 Neighboring gene STARR-seq mESC enhancer starr_01337 Neighboring gene predicted gene, 53562 Neighboring gene CTD small phosphatase 1 Neighboring gene microRNA 26b Neighboring gene villin 1 Neighboring gene STARR-positive B cell enhancer mm9_chr1:74552349-74552650 Neighboring gene CCR4-NOT transcription complex, subunit 9 Neighboring gene phospholipase C, delta 4 Neighboring gene STARR-seq mESC enhancer starr_01339 Neighboring gene zinc finger protein 142 Neighboring gene STARR-positive B cell enhancer ABC_E791 Neighboring gene BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Topoisomerase IIA in adult NSCs regulates SVZ neurogenesis by transcriptional activation of Usp37. Qin S, et al. Nucleic Acids Res, 2022 Sep 9. PMID 36029179, Free PMC Article
    2. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
    3. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767
    4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Topoisomerase IIA in adult NSCs regulates SVZ neurogenesis by transcriptional activation of Usp37.
      Title: Topoisomerase IIA in adult NSCs regulates SVZ neurogenesis by transcriptional activation of Usp37.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein K11-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K48-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 37
    Names
    deubiquitinating enzyme 37
    ubiquitin specific protease 37
    ubiquitin thioesterase 37
    ubiquitin thiolesterase 37
    ubiquitin-specific-processing protease 37
    NP_001297591.1
    NP_795946.2
    XP_006496117.1
    XP_006496120.1
    XP_036021582.1
    XP_036021584.1
    XP_036021585.1
    XP_036021586.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310662.1 → NP_001297591.1  ubiquitin carboxyl-terminal hydrolase 37 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC098570, AK030013, AK035640, BB624535
      Consensus CDS
      CCDS78616.1
      UniProtKB/Swiss-Prot
      B2RT12, Q69ZF6, Q8BZE6, Q8C0R0
      Related
      ENSMUSP00000035445.6, ENSMUST00000044260.11
      Conserved Domains (4) summary
      cd02257
      Location:342 → 601
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      cl02553
      Location:342 → 449
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:342 → 600
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam16674
      Location:3 → 104
      UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37

    2. NM_176972.4 → NP_795946.2  ubiquitin carboxyl-terminal hydrolase 37 isoform 1

      See identical proteins and their annotated locations for NP_795946.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC098570, AK030013, BC139091
      Consensus CDS
      CCDS15050.1
      UniProtKB/Swiss-Prot
      B2RT12, Q69ZF6, Q8BZE6, Q8C0R0
      UniProtKB/TrEMBL
      A0A0R4J2D0
      Related
      ENSMUSP00000140670.2, ENSMUST00000189257.7
      Conserved Domains (3) summary
      cd02257
      Location:886 → 949
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:342 → 601
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam16674
      Location:3 → 105
      UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      74474669..74583447 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165692.1 → XP_036021585.1  ubiquitin carboxyl-terminal hydrolase 37 isoform X1

      UniProtKB/Swiss-Prot
      B2RT12, Q69ZF6, Q8BZE6, Q8C0R0
      UniProtKB/TrEMBL
      A0A0R4J2D0
      Conserved Domains (3) summary
      cd02257
      Location:886 → 949
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:342 → 601
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam16674
      Location:3 → 105
      UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37

    2. XM_006496057.5 → XP_006496120.1  ubiquitin carboxyl-terminal hydrolase 37 isoform X2

      UniProtKB/Swiss-Prot
      B2RT12, Q69ZF6, Q8BZE6, Q8C0R0
      Conserved Domains (3) summary
      COG5207
      Location:342 → 936
      UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]
      pfam00443
      Location:342 → 601
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam16674
      Location:3 → 105
      UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37

    3. XM_006496054.4 → XP_006496117.1  ubiquitin carboxyl-terminal hydrolase 37 isoform X1

      See identical proteins and their annotated locations for XP_006496117.1

      UniProtKB/Swiss-Prot
      B2RT12, Q69ZF6, Q8BZE6, Q8C0R0
      UniProtKB/TrEMBL
      A0A0R4J2D0
      Conserved Domains (3) summary
      cd02257
      Location:886 → 949
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:342 → 601
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam16674
      Location:3 → 105
      UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37

    4. XM_036165691.1 → XP_036021584.1  ubiquitin carboxyl-terminal hydrolase 37 isoform X1

      UniProtKB/Swiss-Prot
      B2RT12, Q69ZF6, Q8BZE6, Q8C0R0
      UniProtKB/TrEMBL
      A0A0R4J2D0
      Conserved Domains (3) summary
      cd02257
      Location:886 → 949
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:342 → 601
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam16674
      Location:3 → 105
      UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37

    5. XM_036165689.1 → XP_036021582.1  ubiquitin carboxyl-terminal hydrolase 37 isoform X1

      UniProtKB/Swiss-Prot
      B2RT12, Q69ZF6, Q8BZE6, Q8C0R0
      UniProtKB/TrEMBL
      A0A0R4J2D0
      Conserved Domains (3) summary
      cd02257
      Location:886 → 949
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:342 → 601
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam16674
      Location:3 → 105
      UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37

    6. XM_036165693.1 → XP_036021586.1  ubiquitin carboxyl-terminal hydrolase 37 isoform X3

      UniProtKB/Swiss-Prot
      B2RT12, Q69ZF6, Q8BZE6, Q8C0R0
      Conserved Domains (2) summary
      pfam00443
      Location:342 → 601
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam16674
      Location:3 → 105
      UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37

    RNA

    1. XR_373256.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C0R0.1 GenPept UniProtKB/Swiss-Prot:Q8C0R0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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