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    Nfatc2 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 [ Mus musculus (house mouse) ]

    Gene ID: 18019, updated on 6-Sep-2021

    Summary

    Official Symbol
    Nfatc2provided by MGI
    Official Full Name
    nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2provided by MGI
    Primary source
    MGI:MGI:102463
    See related
    Ensembl:ENSMUSG00000027544
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NF; NFA; NFAT1; Nfatp; NF-ATp; NF-ATc2; NFAT1-D; AI607462
    Expression
    Broad expression in spleen adult (RPKM 4.4), thymus adult (RPKM 3.6) and 24 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Nfatc2 in Genome Data Viewer
    Location:
    2 H3; 2 88.91 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (168318330..168443900, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (168476410..168601657, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (168301910..168427155, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 33262 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene predicted gene, 33413 Neighboring gene microRNA 7004 Neighboring gene ATPase, class II, type 9A Neighboring gene VISTA enhancer mm1375

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (4)  1 citation
    • Chemically induced (ENU) (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in B cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in calcineurin-NFAT signaling cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within calcineurin-NFAT signaling cascade IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cytokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within cytokine production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within myotube cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of vascular associated smooth muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of B cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of myoblast fusion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to xenobiotic stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of transcription regulator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of transcription regulator complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 

    General protein information

    Preferred Names
    nuclear factor of activated T-cells, cytoplasmic 2
    Names
    NFAT pre-existing subunit
    T-cell transcription factor NFAT1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037177.2NP_001032254.1  nuclear factor of activated T-cells, cytoplasmic 2 isoform b

      See identical proteins and their annotated locations for NP_001032254.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2, also known as IB-IIL-VIIa) lacks four 3' exons but contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AK135414, AW049827, EU887600
      Consensus CDS
      CCDS17113.1
      UniProtKB/TrEMBL
      B5B2R5
      Related
      ENSMUSP00000029057.6, ENSMUST00000029057.13
      Conserved Domains (2) summary
      cd07881
      Location:400574
      RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
      cl15674
      Location:579618
      IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
    2. NM_001037178.2NP_001032255.1  nuclear factor of activated T-cells, cytoplasmic 2 isoform c

      See identical proteins and their annotated locations for NP_001032255.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3, also known as IA-IIS-VIIa) contains alternate 5' and 3' exon structure, and it thus differs in both UTRs, initiates translation at a downstream in-frame start codon, and differs in the 3' coding region, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus and has a distinct C-terminus, compared to isoform a. Both variants 3 and 16 encode isoform c.
      Source sequence(s)
      AK044489, AW049827, EU887601
      Consensus CDS
      CCDS17114.1
      UniProtKB/TrEMBL
      Q8C443
      Related
      ENSMUSP00000130875.2, ENSMUST00000171689.8
      Conserved Domains (2) summary
      cd07881
      Location:179353
      RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
      cl15674
      Location:358397
      IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
    3. NM_001136073.2NP_001129545.1  nuclear factor of activated T-cells, cytoplasmic 2 isoform d

      See identical proteins and their annotated locations for NP_001129545.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4, also known as IB-IIL-Xa) contains an additional exon that results in an alternate 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (d) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AK135414, BP757417, EU887582
      Consensus CDS
      CCDS50803.1
      UniProtKB/TrEMBL
      B5B2P7
      Related
      ENSMUSP00000104812.2, ENSMUST00000109184.8
      Conserved Domains (2) summary
      cd07881
      Location:400574
      RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
      cd01178
      Location:579679
      IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
    4. NM_001291168.1NP_001278097.1  nuclear factor of activated T-cells, cytoplasmic 2 isoform e

      See identical proteins and their annotated locations for NP_001278097.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5, also known as IA-IIL-deltaXa) contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (e) has a distinct N-terminus and is shorter than isoform a.
      Source sequence(s)
      AK044489, BP757417, EU887585, EU887587
      UniProtKB/TrEMBL
      B5B2Q2, Q3TTU8
      Conserved Domains (2) summary
      cd07881
      Location:380554
      RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
      cd01178
      Location:559659
      IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
    5. NM_001291169.1NP_001278098.1  nuclear factor of activated T-cells, cytoplasmic 2 isoform f

      See identical proteins and their annotated locations for NP_001278098.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6, also known as IA-deltaII-Xa) contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and 5' coding region, and it also contains an additional exon that results in an alternate 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (f) has distinct N- and C-termini and is shorter than isoform a.
      Source sequence(s)
      AK044489, BP757417, EU887581
      UniProtKB/TrEMBL
      B5B2P6
      Conserved Domains (2) summary
      cd07881
      Location:380554
      RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
      cd01178
      Location:559659
      IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
    6. NM_001291170.1NP_001278099.1  nuclear factor of activated T-cells, cytoplasmic 2 isoform g

      See identical proteins and their annotated locations for NP_001278099.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7, also known as IA-IIS-deltaXa) contains alternate 5' exon structure, and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (g) is shorter at the N-terminus, compared to isoform a. Both variants 7 and 14 encode isoform g.
      Source sequence(s)
      AK044489, BP757417, EU887585, EU887589
      UniProtKB/TrEMBL
      B5B2Q4, Q3TTU8
      Conserved Domains (2) summary
      cd07881
      Location:179353
      RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
      cd01178
      Location:358458
      IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
    7. NM_001291171.1NP_001278100.1  nuclear factor of activated T-cells, cytoplasmic 2 isoform h

      See identical proteins and their annotated locations for NP_001278100.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8, also known as IA-deltaII-Xa) contains alternate 5' and 3' exon structure, and it thus differs in both UTRs, initiates translation at a downstream in-frame start codon, and differs in the 3' coding region, compared to variant 1. The encoded isoform (h) is shorter at at the N-terminus and has a distinct C-terminus, compared to isoform a. Both variants 8 and 13 encode isoform h.
      Source sequence(s)
      AK044489, BP757417, EU887585
      UniProtKB/TrEMBL
      Q3TTU8
      Related
      ENSMUST00000151292.8
      Conserved Domains (2) summary
      cd01178
      Location:129229
      IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
      cl08275
      Location:1124
      RHD-n; N-terminal sub-domain of the Rel homology domain (RHD)
    8. NM_001291172.1NP_001278101.1  nuclear factor of activated T-cells, cytoplasmic 2 isoform i

      See identical proteins and their annotated locations for NP_001278101.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9, also known as IA-IIL-VIIa) contains alternate 5' and 3' exon structure, and it thus differs in both UTRs and in the 5' and 3' coding regions, compared to variant 1. The encoded isoform (i) has distinct N- and C-termini and is shorter than isoform a.
      Source sequence(s)
      AK044489, AW049827, EU887599
      Consensus CDS
      CCDS71201.1
      UniProtKB/TrEMBL
      A2AQC8
      Related
      ENSMUSP00000118329.2, ENSMUST00000137451.2
      Conserved Domains (2) summary
      cd07881
      Location:380554
      RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
      cl15674
      Location:559598
      IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
    9. NM_001291173.1NP_001278102.1  nuclear factor of activated T-cells, cytoplasmic 2 isoform j

      See identical proteins and their annotated locations for NP_001278102.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10, also known as IA-deltaII-deltaXa) contains alternate 5' exon structure, and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (j) is shorter at the N-terminus, compared to isoform a. Both variants 10 and 15 encode isoform j.
      Source sequence(s)
      AK044489, BP757417, EU887585, EU887591
      UniProtKB/TrEMBL
      B5B2Q6, Q3TTU8
      Conserved Domains (2) summary
      cd01178
      Location:129229
      IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
      cl08275
      Location:1124
      RHD-n; N-terminal sub-domain of the Rel homology domain (RHD)
    10. NM_001291174.1NP_001278103.1  nuclear factor of activated T-cells, cytoplasmic 2 isoform k

      See identical proteins and their annotated locations for NP_001278103.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11, also known as IA-IIS-Xa) contains alternate 5' and 3' exon structure, and it thus differs in both UTRs, initiates translation at a downstream in-frame start codon, and differs in the 3' coding region, compared to variant 1. The encoded isoform (k) is shorter at the N-terminus and has a distinct C-terminus, compared to isoform a. Both variants 11 and 12 encode isoform k.
      Source sequence(s)
      AK044489, BP757417, EU887583
      UniProtKB/TrEMBL
      B5B2P8
      Conserved Domains (2) summary
      cd07881
      Location:179353
      RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
      cd01178
      Location:358458
      IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
    11. NM_001291175.1NP_001278104.1  nuclear factor of activated T-cells, cytoplasmic 2 isoform k

      See identical proteins and their annotated locations for NP_001278104.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (12, also known as IB-IIS-Xa) contains alternate 5' and 3' exon structure, and it thus differs in both UTRs, initiates translation at a downstream in-frame start codon, and differs in the 3' coding region, compared to variant 1. The encoded isoform (k) is shorter at the N-terminus and has a distinct C-terminus, compared to isoform a. Both variants 11 and 12 encode isoform k.
      Source sequence(s)
      AK135414, BP757417, EU887584
      UniProtKB/TrEMBL
      B5B2P8
      Conserved Domains (2) summary
      cd07881
      Location:179353
      RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
      cd01178
      Location:358458
      IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
    12. NM_001291176.1NP_001278105.1  nuclear factor of activated T-cells, cytoplasmic 2 isoform h

      See identical proteins and their annotated locations for NP_001278105.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (13, also known as IB-deltaII-Xa) contains alternate 5' and 3' exon structure, and it thus differs in both UTRs, initiates translation at a downstream in-frame start codon, and differs in the 3' coding region, compared to variant 1. The encoded isoform (h) is shorter at at the N-terminus and has a distinct C-terminus, compared to isoform a. Both variants 8 and 13 encode isoform h.
      Source sequence(s)
      AK135414, BP757417, EU887586
      UniProtKB/TrEMBL
      Q3TTU8
      Conserved Domains (2) summary
      cd01178
      Location:129229
      IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
      cl08275
      Location:1124
      RHD-n; N-terminal sub-domain of the Rel homology domain (RHD)
    13. NM_001291177.1NP_001278106.1  nuclear factor of activated T-cells, cytoplasmic 2 isoform g

      See identical proteins and their annotated locations for NP_001278106.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (14, also known as IB-IIS-deltaXa) contains alternate 5' exon structure, and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (g) is shorter at the N-terminus, compared to isoform a. Both variants 7 and 14 encode isoform g.
      Source sequence(s)
      AK135414, BP757417, EU887581, EU887590
      UniProtKB/TrEMBL
      B5B2P6, B5B2Q4
      Conserved Domains (2) summary
      cd07881
      Location:179353
      RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
      cd01178
      Location:358458
      IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
    14. NM_001291178.1NP_001278107.1  nuclear factor of activated T-cells, cytoplasmic 2 isoform j

      See identical proteins and their annotated locations for NP_001278107.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (15, also known as IB-deltaII-deltaXa) contains alternate 5' exon structure, and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (j) is shorter at the N-terminus, compared to isoform a. Both variants 10 and 15 encode isoform j.
      Source sequence(s)
      AK135414, BP757417, EU887581, EU887592
      UniProtKB/TrEMBL
      B5B2P6, B5B2Q6
      Conserved Domains (2) summary
      cd01178
      Location:129229
      IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
      cl08275
      Location:1124
      RHD-n; N-terminal sub-domain of the Rel homology domain (RHD)
    15. NM_001291179.1NP_001278108.1  nuclear factor of activated T-cells, cytoplasmic 2 isoform c

      See identical proteins and their annotated locations for NP_001278108.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (16, also known as IB-IIS-VIIa) contains alternate 5' and 3' exon structure, and it thus differs in both UTRs, initiates translation at a downstream in-frame start codon, and differs in the 3' coding region, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus and has a distinct C-terminus, compared to isoform a. Both variants 2 and 16 encode isoform c.
      Source sequence(s)
      AK135414, AW049827, EU887602
      Consensus CDS
      CCDS17114.1
      UniProtKB/TrEMBL
      Q8C443
      Conserved Domains (2) summary
      cd07881
      Location:179353
      RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
      cl15674
      Location:358397
      IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
    16. NM_010899.3NP_035029.2  nuclear factor of activated T-cells, cytoplasmic 2 isoform a

      See identical proteins and their annotated locations for NP_035029.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1, also known as IB-IIL-deltaXa) encodes the longest isoform (a).
      Source sequence(s)
      AK135414, BP757417, EU887581, EU887588
      Consensus CDS
      CCDS17112.1
      UniProtKB/Swiss-Prot
      Q60591
      UniProtKB/TrEMBL
      B5B2P6
      Related
      ENSMUSP00000074198.4, ENSMUST00000074618.10
      Conserved Domains (2) summary
      cd07881
      Location:400574
      RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
      cd01178
      Location:579679
      IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.

    RNA

    1. NR_111897.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (17, also known as IA-deltaII-VIIa) contains alternate 5' and 3' exon structure, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AK044489, AW049827, EU887603
    2. NR_111898.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (18, also known as IB-deltaII-VIIa) contains alternate 5' and 3' exon structure, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AK135414, AW049827, EU887604

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      168318330..168443900 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159313.1XP_036015206.1  nuclear factor of activated T-cells, cytoplasmic 2 isoform X1

      Conserved Domains (2) summary
      cd01178
      Location:261361
      IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
      cl08275
      Location:128256
      RHD-n; N-terminal sub-domain of the Rel homology domain (RHD)
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