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    Zfp608 zinc finger protein 608 [ Mus musculus (house mouse) ]

    Gene ID: 269023, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Zfp608provided by MGI
    Official Full Name
    zinc finger protein 608provided by MGI
    Primary source
    MGI:MGI:2442338
    See related
    Ensembl:ENSMUSG00000052713 AllianceGenome:MGI:2442338
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Znf608; 4932417D18Rik; D430007A19Rik
    Summary
    Predicted to enable metal ion binding activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in cerebral cortex; cerebral cortex intermediate zone; cerebral cortex subventricular zone; cerebral cortex ventricular layer; and cortical plate. Orthologous to human ZNF608 (zinc finger protein 608). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E14 (RPKM 3.8), whole brain E14.5 (RPKM 3.5) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    18 D3; 18 29.28 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (55021117..55125690, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (54888045..54992591, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene high mobility group box 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_44634 Neighboring gene predicted gene, 33732 Neighboring gene STARR-seq mESC enhancer starr_44636 Neighboring gene STARR-positive B cell enhancer ABC_E5660 Neighboring gene predicted gene, 54030 Neighboring gene STARR-seq mESC enhancer starr_44641 Neighboring gene STARR-positive B cell enhancer ABC_E8717 Neighboring gene STARR-positive B cell enhancer ABC_E1958 Neighboring gene STARR-seq mESC enhancer starr_44642 Neighboring gene predicted gene 4221 Neighboring gene predicted gene, 41731 Neighboring gene STARR-positive B cell enhancer mm9_chr18:55210076-55210376 Neighboring gene predicted gene, 24183

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Reciprocal regulation of Rag expression in thymocytes by the zinc-finger proteins, Zfp608 and Zfp609. Reed NP, et al. Genes Immun, 2013 Jan. PMID 23076336, Free PMC Article
    2. Transcriptional programs in transient embryonic zones of the cerebral cortex defined by high-resolution mRNA sequencing. Ayoub AE, et al. Proc Natl Acad Sci U S A, 2011 Sep 6. PMID 21873192, Free PMC Article
    3. Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation. Barnes CE, et al. Mol Omics, 2022 Jan 17. PMID 34709266, Free PMC Article
    4. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
    5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Zfp608 represses Rag1 and Rag2 expression indirectly by repressing the expression of Zfp609 in tymocytes.
      Title: Reciprocal regulation of Rag expression in thymocytes by the zinc-finger proteins, Zfp608 and Zfp609.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC116601

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of T cell differentiation in thymus TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 608

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360787.1 → NP_001347716.1  zinc finger protein 608 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC127314
      Conserved Domains (2) summary
      COG5189
      Location:85 → 166
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      PTZ00108
      Location:676 → 894
      PTZ00108; DNA topoisomerase 2-like protein; Provisional

    2. NM_175751.4 → NP_786927.2  zinc finger protein 608 isoform 1

      See identical proteins and their annotated locations for NP_786927.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC127314, BC092219
      Consensus CDS
      CCDS37824.1
      UniProtKB/Swiss-Prot
      Q56A10, Q6ZPU8, Q8BIG5, Q8BJ06
      UniProtKB/TrEMBL
      B9EKR3
      Related
      ENSMUSP00000068192.6, ENSMUST00000064763.7
      Conserved Domains (2) summary
      COG5189
      Location:511 → 592
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      PTZ00108
      Location:1102 → 1320
      PTZ00108; DNA topoisomerase 2-like protein; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      55021117..55125690 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006525957.5 → XP_006526020.1  zinc finger protein 608 isoform X1

      See identical proteins and their annotated locations for XP_006526020.1

      UniProtKB/Swiss-Prot
      Q56A10, Q6ZPU8, Q8BIG5, Q8BJ06
      UniProtKB/TrEMBL
      B9EKR3
      Conserved Domains (2) summary
      COG5189
      Location:511 → 592
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      PTZ00108
      Location:1102 → 1320
      PTZ00108; DNA topoisomerase 2-like protein; Provisional

    2. XM_030250475.2 → XP_030106335.1  zinc finger protein 608 isoform X2

      Conserved Domains (2) summary
      COG5189
      Location:85 → 166
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      PTZ00108
      Location:676 → 894
      PTZ00108; DNA topoisomerase 2-like protein; Provisional

    3. XM_030250473.2 → XP_030106333.1  zinc finger protein 608 isoform X1

      UniProtKB/Swiss-Prot
      Q56A10, Q6ZPU8, Q8BIG5, Q8BJ06
      UniProtKB/TrEMBL
      B9EKR3
      Conserved Domains (2) summary
      COG5189
      Location:511 → 592
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      PTZ00108
      Location:1102 → 1320
      PTZ00108; DNA topoisomerase 2-like protein; Provisional

    RNA

    1. XR_004939857.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q56A10.1 GenPept UniProtKB/Swiss-Prot:Q56A10

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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