Tigar Trp53 induced glycolysis regulatory phosphatase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tigarprovided by MGI
Official Full Name: Trp53 induced glycolysis regulatory phosphataseprovided by MGI
Primary source: MGI:MGI:2442752
See related: Ensembl:ENSMUSG00000038028 AllianceGenome:MGI:2442752
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 9630033F20Rik
Summary: Enables fructose-2,6-bisphosphate 2-phosphatase activity. Involved in negative regulation of neuron death and response to ischemia. Acts upstream of or within several processes, including fructose 2,6-bisphosphate metabolic process; negative regulation of catabolic process; and positive regulation of cardiac muscle cell apoptotic process. Located in mitochondrion. Is expressed in brain; immune system; and liver. Orthologous to human TIGAR (TP53 induced glycolysis regulatory phosphatase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in heart adult (RPKM 8.1), cerebellum adult (RPKM 5.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 F3; 6 61.92 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (127062079..127086564, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (127085116..127109552, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knockout of TIGAR enhances myocardial phosphofructokinase activity and preserves diastolic function in heart failure.
Title: Knockout of TIGAR enhances myocardial phosphofructokinase activity and preserves diastolic function in heart failure.
TIGAR alleviates oxidative stress in brain with extended ischemia via a pentose phosphate pathway-independent manner.
Title: TIGAR alleviates oxidative stress in brain with extended ischemia via a pentose phosphate pathway-independent manner.
The inhibition of TRIM35-mediated TIGAR ubiquitination enhances mitochondrial fusion and alleviates renal ischemia-reperfusion injury.
Title: The inhibition of TRIM35-mediated TIGAR ubiquitination enhances mitochondrial fusion and alleviates renal ischemia-reperfusion injury.
TIGAR deficiency enhances skeletal muscle thermogenesis by increasing neuromuscular junction cholinergic signaling.
Title: TIGAR deficiency enhances skeletal muscle thermogenesis by increasing neuromuscular junction cholinergic signaling.
TIGAR deficiency sensitizes angiotensin-II-induced renal fibrosis and glomerular injury.
Title: TIGAR deficiency sensitizes angiotensin-II-induced renal fibrosis and glomerular injury.
TIGAR plays neuroprotective roles in KA-induced excitotoxicity through reducing neuroinflammation and improving mitochondrial function.
Title: TIGAR plays neuroprotective roles in KA-induced excitotoxicity through reducing neuroinflammation and improving mitochondrial function.
Regulatory role of TIGAR on endothelial metabolism and angiogenesis.
Title: Regulatory role of TIGAR on endothelial metabolism and angiogenesis.
Impaired ribosome biogenesis checkpoint activation induces p53-dependent MCL-1 degradation and MYC-driven lymphoma death.
Title: Impaired ribosome biogenesis checkpoint activation induces p53-dependent MCL-1 degradation and MYC-driven lymphoma death.
Sirtuin 3 Alleviates Diabetic Cardiomyopathy by Regulating TIGAR and Cardiomyocyte Metabolism.
Title: Sirtuin 3 Alleviates Diabetic Cardiomyopathy by Regulating TIGAR and Cardiomyocyte Metabolism.
TIGAR mitigates atherosclerosis by promoting cholesterol efflux from macrophages.
Title: TIGAR mitigates atherosclerosis by promoting cholesterol efflux from macrophages.

Submit: New GeneRIF Correction See all GeneRIFs (27)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (7) 1 citation
Endonuclease-mediated (4)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:235559

AI595337 (e-PCR)
- UniSTS:165491

C85509 (e-PCR)
- UniSTS:208031

RH126720 (e-PCR)
- UniSTS:208032

NoName (e-PCR)
- UniSTS:490673

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables fructose-2,6-bisphosphate 2-phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables fructose-2,6-bisphosphate 2-phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables fructose-2,6-bisphosphate 2-phosphatase activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within autophagy	IEA Inferred from Electronic Annotation more info
acts_upstream_of cardiac muscle cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to cobalt ion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hypoxia	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fructose 2,6-bisphosphate metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of glucose catabolic process to lactate via pyruvate	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of glycolytic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within intestinal epithelial cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of mitophagy	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of glucose catabolic process to lactate via pyruvate	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of glycolytic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of glycolytic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of kinase activity	IC Inferred by Curator more info	PubMed
acts_upstream_of_or_within negative regulation of mitophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of programmed cell death	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of reactive oxygen species metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA repair	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cardiac muscle cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of hexokinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of pentose-phosphate shunt	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of reactive oxygen species metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of pentose-phosphate shunt	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of pentose-phosphate shunt	ISO Inferred from Sequence Orthology more info
involved_in regulation of response to DNA damage checkpoint signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to gamma radiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to ischemia	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to xenobiotic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: fructose-2,6-bisphosphatase TIGAR

Names: TP53-induced glycolysis and apoptosis regulator; TP53-induced glycolysis regulatory phosphatase; Trp53 induced glycolysis repulatory phosphatase; probable fructose-2,6-bisphosphatase TIGAR

NP_795977.1

EC 3.1.3.46

XP_006506317.1

EC 3.1.3.46

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_177003.5 → NP_795977.1 fructose-2,6-bisphosphatase TIGAR

See identical proteins and their annotated locations for NP_795977.1

Status: VALIDATED

Source sequence(s)

AC163683, AK145896

Consensus CDS

CCDS20563.1

UniProtKB/Swiss-Prot

Q8BZA9

UniProtKB/TrEMBL

B2RWB7

Related

ENSMUSP00000048643.9, ENSMUST00000039913.9

Conserved Domains (1) summary

pfam00300
Location:6 → 241

His_Phos_1; Histidine phosphatase superfamily (branch 1)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

127062079..127086564 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006506254.2 → XP_006506317.1 fructose-2,6-bisphosphatase TIGAR isoform X1

Conserved Domains (1) summary

cl11399
Location:1 → 163

HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction