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    Galnt13 polypeptide N-acetylgalactosaminyltransferase 13 [ Mus musculus (house mouse) ]

    Gene ID: 271786, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Galnt13provided by MGI
    Official Full Name
    polypeptide N-acetylgalactosaminyltransferase 13provided by MGI
    Primary source
    MGI:MGI:2139447
    See related
    Ensembl:ENSMUSG00000060988 AllianceGenome:MGI:2139447
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A230002A12; A230020F20
    Summary
    Enables polypeptide N-acetylgalactosaminyltransferase activity. Acts upstream of or within protein O-linked glycosylation. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus. Is expressed in heart; liver; lung; metanephros; and nervous system. Orthologous to human GALNT13 (polypeptide N-acetylgalactosaminyltransferase 13). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in cerebellum adult (RPKM 5.4), frontal lobe adult (RPKM 1.6) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Galnt13 in Genome Data Viewer
    Location:
    2 C1.1; 2 30.77 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (54326217..55008321)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (54436211..55118309)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_04511 Neighboring gene STARR-seq mESC enhancer starr_04512 Neighboring gene predicted gene 14035 Neighboring gene ribosomal protein S9 pseudogene Neighboring gene predicted gene, 24549 Neighboring gene STARR-seq mESC enhancer starr_04513 Neighboring gene STARR-seq mESC enhancer starr_04514 Neighboring gene STARR-seq mESC enhancer starr_04516 Neighboring gene predicted gene, 25489 Neighboring gene STARR-seq mESC enhancer starr_04517 Neighboring gene STARR-seq mESC enhancer starr_04518 Neighboring gene STARR-positive B cell enhancer mm9_chr2:55104656-55104956 Neighboring gene cathepsin B pseudogene Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. pp-GalNAc-T13 induces high metastatic potential of murine Lewis lung cancer by generating trimeric Tn antigen. Matsumoto Y, et al. Biochem Biophys Res Commun, 2012 Mar 2. PMID 22306014
    2. T-cell-specific deletion of a polypeptide N-acetylgalactosaminyl-transferase gene by site-directed recombination. Hennet T, et al. Proc Natl Acad Sci U S A, 1995 Dec 19. PMID 8618846, Free PMC Article
    3. Polypeptide N-Acetylgalactosaminyltransferase 13 Contributes to Neurogenesis via Stabilizing the Mucin-type O-Glycoprotein Podoplanin. Xu Y, et al. J Biol Chem, 2016 Nov 4. PMID 27629416, Free PMC Article
    4. Trimeric Tn antigen on syndecan 1 produced by ppGalNAc-T13 enhances cancer metastasis via a complex formation with integrin α5β1 and matrix metalloproteinase 9. Matsumoto Y, et al. J Biol Chem, 2013 Aug 16. PMID 23814067, Free PMC Article
    5. Expression of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase isoforms in murine tissues determined by real-time PCR: a new view of a large family. Young WW Jr, et al. Glycobiology, 2003 Jul. PMID 12651884

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study suggests that ppGalNAc-T13 contributes to neuronal differentiation through glycosylating and stabilizing PDPN, which provides insights into the regulatory roles of O-glycosylation in mammalian neural development.
      Title: Polypeptide N-Acetylgalactosaminyltransferase 13 Contributes to Neurogenesis via Stabilizing the Mucin-type O-Glycoprotein Podoplanin.
    2. high expression of the ppGalNAc-T13 gene generates tTn antigen on Syndecan 1, leading to enhanced invasion and metastasis via the formation of a complex consisting of integrin alpha5beta1, Syndecan 1, and MMP-9 in the glycolipid-enriched microdomain/rafts.
      Title: Trimeric Tn antigen on syndecan 1 produced by ppGalNAc-T13 enhances cancer metastasis via a complex formation with integrin α5β1 and matrix metalloproteinase 9.
    3. These data suggested that high expression of pp-GalNAc-T13 gene generated trimeric Tn antigen on Syndecan-1, leading to the enhanced metastasis.
      Title: pp-GalNAc-T13 induces high metastatic potential of murine Lewis lung cancer by generating trimeric Tn antigen.
    4. cloning and characterization of pp-GalNAc-T13; expressed in all neuroblastoma cells examined and primary cultured neurons but not in glioblastoma cells and primary cultured astrocytes
      Title: Cloning and characterization of a new human UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase, designated pp-GalNAc-T13, that is specifically expressed in neurons and synthesizes GalNAc alpha-serine/threonine antigen.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (3) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables polypeptide N-acetylgalactosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables polypeptide N-acetylgalactosaminyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables polypeptide N-acetylgalactosaminyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein O-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein O-linked glycosylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein O-linked glycosylation via serine ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein O-linked glycosylation via threonine ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    polypeptide N-acetylgalactosaminyltransferase 13
    Names
    UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 13
    UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13
    galNAc-T13
    polypeptide GalNAc transferase 13
    pp-GaNTase 13
    pp-GalNAc-T13
    protein-UDP acetylgalactosaminyltransferase 13
    NP_766618.2
    XP_006498150.1
    XP_006498154.1
    XP_006498155.1
    XP_006498156.1
    XP_036018146.1
    XP_036018147.1
    XP_036018148.1
    XP_036018149.1
    XP_036018150.1
    XP_036018151.1
    XP_036018152.1
    XP_036018153.1
    XP_036018154.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173030.2 → NP_766618.2  polypeptide N-acetylgalactosaminyltransferase 13

      See identical proteins and their annotated locations for NP_766618.2

      Status: VALIDATED

      Source sequence(s)
      AK038387, AK038492, AL844895
      Consensus CDS
      CCDS16041.1
      UniProtKB/Swiss-Prot
      Q8BLE4, Q8BYT3, Q8CF93
      UniProtKB/TrEMBL
      A2RRI8
      Related
      ENSMUSP00000108254.2, ENSMUST00000112635.8
      Conserved Domains (2) summary
      cd02510
      Location:118 → 418
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      pfam00652
      Location:431 → 547
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      54326217..55008321
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498091.4 → XP_006498154.1  polypeptide N-acetylgalactosaminyltransferase 13 isoform X4

      See identical proteins and their annotated locations for XP_006498154.1

      UniProtKB/Swiss-Prot
      Q8BLE4, Q8BYT3, Q8CF93
      UniProtKB/TrEMBL
      A2RRI8
      Related
      ENSMUSP00000108255.2, ENSMUST00000112636.8
      Conserved Domains (2) summary
      cd02510
      Location:118 → 418
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      pfam00652
      Location:431 → 547
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    2. XM_036162258.1 → XP_036018151.1  polypeptide N-acetylgalactosaminyltransferase 13 isoform X3

      Conserved Domains (2) summary
      cd02510
      Location:118 → 418
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      pfam00652
      Location:431 → 548
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    3. XM_036162257.1 → XP_036018150.1  polypeptide N-acetylgalactosaminyltransferase 13 isoform X3

      Conserved Domains (2) summary
      cd02510
      Location:118 → 418
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      pfam00652
      Location:431 → 548
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    4. XM_006498092.3 → XP_006498155.1  polypeptide N-acetylgalactosaminyltransferase 13 isoform X4

      See identical proteins and their annotated locations for XP_006498155.1

      UniProtKB/Swiss-Prot
      Q8BLE4, Q8BYT3, Q8CF93
      UniProtKB/TrEMBL
      A2RRI8
      Related
      ENSMUSP00000063464.6, ENSMUST00000068595.6
      Conserved Domains (2) summary
      cd02510
      Location:118 → 418
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      pfam00652
      Location:431 → 547
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    5. XM_036162260.1 → XP_036018153.1  polypeptide N-acetylgalactosaminyltransferase 13 isoform X3

      Conserved Domains (2) summary
      cd02510
      Location:118 → 418
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      pfam00652
      Location:431 → 548
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    6. XM_036162261.1 → XP_036018154.1  polypeptide N-acetylgalactosaminyltransferase 13 isoform X4

      UniProtKB/Swiss-Prot
      Q8BLE4, Q8BYT3, Q8CF93
      UniProtKB/TrEMBL
      A2RRI8
      Related
      ENSMUSP00000108253.2, ENSMUST00000112634.8
      Conserved Domains (2) summary
      cd02510
      Location:118 → 418
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      pfam00652
      Location:431 → 547
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    7. XM_006498087.4 → XP_006498150.1  polypeptide N-acetylgalactosaminyltransferase 13 isoform X2

      See identical proteins and their annotated locations for XP_006498150.1

      Conserved Domains (2) summary
      cd02510
      Location:160 → 460
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      pfam00652
      Location:473 → 589
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    8. XM_036162253.1 → XP_036018146.1  polypeptide N-acetylgalactosaminyltransferase 13 isoform X1

      Conserved Domains (2) summary
      cd02510
      Location:160 → 460
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      pfam00652
      Location:473 → 590
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    9. XM_036162254.1 → XP_036018147.1  polypeptide N-acetylgalactosaminyltransferase 13 isoform X1

      Conserved Domains (2) summary
      cd02510
      Location:160 → 460
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      pfam00652
      Location:473 → 590
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    10. XM_006498093.5 → XP_006498156.1  polypeptide N-acetylgalactosaminyltransferase 13 isoform X5

      Conserved Domains (1) summary
      cd02510
      Location:160 → 429
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans

    11. XM_036162255.1 → XP_036018148.1  polypeptide N-acetylgalactosaminyltransferase 13 isoform X1

      Conserved Domains (2) summary
      cd02510
      Location:160 → 460
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      pfam00652
      Location:473 → 590
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    12. XM_036162259.1 → XP_036018152.1  polypeptide N-acetylgalactosaminyltransferase 13 isoform X3

      Conserved Domains (2) summary
      cd02510
      Location:118 → 418
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      pfam00652
      Location:431 → 548
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    13. XM_036162256.1 → XP_036018149.1  polypeptide N-acetylgalactosaminyltransferase 13 isoform X1

      Conserved Domains (2) summary
      cd02510
      Location:160 → 460
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      pfam00652
      Location:473 → 590
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    RNA

    1. XR_374098.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CF93.1 GenPept UniProtKB/Swiss-Prot:Q8CF93

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