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    Tmcc1 transmembrane and coiled coil domains 1 [ Mus musculus (house mouse) ]

    Gene ID: 330401, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Tmcc1provided by MGI
    Official Full Name
    transmembrane and coiled coil domains 1provided by MGI
    Primary source
    MGI:MGI:2442368
    See related
    Ensembl:ENSMUSG00000030126 AllianceGenome:MGI:2442368
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0779; 3632431M01Rik
    Summary
    Predicted to enable identical protein binding activity. Predicted to be involved in several processes, including endosome fission; endosome membrane tubulation; and membrane fission. Predicted to be located in cytosol; endoplasmic reticulum-endosome membrane contact site; and rough endoplasmic reticulum. Predicted to be active in endomembrane system. Is expressed in nervous system and olfactory epithelium. Orthologous to human TMCC1 (transmembrane and coiled-coil domain family 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 13.3), whole brain E14.5 (RPKM 6.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    6 E3; 6 53.72 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (115995572..116170485, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (116018611..116193521, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:115921305-115921458 Neighboring gene plexin D1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:115938993-115939194 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:115939698-115939944 Neighboring gene predicted gene, 53336 Neighboring gene STARR-positive B cell enhancer ABC_E3672 Neighboring gene STARR-positive B cell enhancer ABC_E6473 Neighboring gene RIKEN cDNA 9530062K07 gene Neighboring gene H2A histone family, member Z pseudogene Neighboring gene WASH complex subunit 2 Neighboring gene predicted gene, 52873

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Circular RNA Tmcc1 improves astrocytic glutamate metabolism and spatial memory via NF-κB and CREB signaling in a bile duct ligation mouse model: transcriptional and cellular analyses. Jo D, et al. J Neuroinflammation, 2023 May 22. PMID 37217942, Free PMC Article
    2. In silico identification of new candidate genes for hereditary congenital facial paresis. Tomás-Roca L, et al. Int J Dev Neurosci, 2011 Jun. PMID 21345367
    3. Identifying new candidate genes for hereditary facial paresis on chromosome 3q21-q22 by RNA in situ hybridization in mouse. van der Zwaag B, et al. Genomics, 2005 Jul. PMID 15953540
    4. Phosphoproteomic analysis of the developing mouse brain. Ballif BA, et al. Mol Cell Proteomics, 2004 Nov. PMID 15345747
    5. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Circular RNA Tmcc1 improves astrocytic glutamate metabolism and spatial memory via NF-kappaB and CREB signaling in a bile duct ligation mouse model: transcriptional and cellular analyses.
      Title: Circular RNA Tmcc1 improves astrocytic glutamate metabolism and spatial memory via NF-κB and CREB signaling in a bile duct ligation mouse model: transcriptional and cellular analyses.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endosomal transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endosomal transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endosome fission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endosome fission ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endosome membrane tubulation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endosome membrane tubulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in membrane fission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in membrane fission ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum-endosome membrane contact site ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in rough endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane and coiled-coil domains protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364577.1 → NP_001351506.1  transmembrane and coiled-coil domains protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK028322, AK036701, AK164892, BE983627
      Consensus CDS
      CCDS90105.1
      Related
      ENSMUSP00000133665.3, ENSMUST00000172510.4
      Conserved Domains (1) summary
      pfam10267
      Location:1 → 314
      Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

    2. NM_177412.1 → NP_803131.1  transmembrane and coiled-coil domains protein 1 isoform 1

      See identical proteins and their annotated locations for NP_803131.1

      Status: VALIDATED

      Source sequence(s)
      AK173022, BY293575
      Consensus CDS
      CCDS51881.1
      UniProtKB/Swiss-Prot
      Q69ZZ6, Q8CEF4
      UniProtKB/TrEMBL
      Q8K2V2
      Related
      ENSMUSP00000086285.4, ENSMUST00000088896.10
      Conserved Domains (1) summary
      pfam10267
      Location:227 → 634
      Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      115995572..116170485 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036166251.1 → XP_036022144.1  transmembrane and coiled-coil domains protein 1 isoform X6

      Conserved Domains (1) summary
      pfam10267
      Location:41 → 448
      Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

    2. XM_006506309.3 → XP_006506372.1  transmembrane and coiled-coil domains protein 1 isoform X2

      Conserved Domains (1) summary
      pfam10267
      Location:113 → 520
      Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

    3. XM_006506308.4 → XP_006506371.1  transmembrane and coiled-coil domains protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006506371.1

      UniProtKB/Swiss-Prot
      Q69ZZ6, Q8CEF4
      UniProtKB/TrEMBL
      Q8K2V2
      Conserved Domains (1) summary
      pfam10267
      Location:227 → 634
      Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

    4. XM_030255485.2 → XP_030111345.1  transmembrane and coiled-coil domains protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q69ZZ6, Q8CEF4
      UniProtKB/TrEMBL
      Q8K2V2
      Conserved Domains (1) summary
      pfam10267
      Location:227 → 634
      Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

    5. XM_036166253.1 → XP_036022146.1  transmembrane and coiled-coil domains protein 1 isoform X8

      UniProtKB/TrEMBL
      Q8K2V2
      Related
      ENSMUSP00000032222.10, ENSMUST00000032222.16
      Conserved Domains (1) summary
      pfam10267
      Location:271 → 678
      Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

    6. XM_017321657.3 → XP_017177146.1  transmembrane and coiled-coil domains protein 1 isoform X7

      UniProtKB/Swiss-Prot
      Q69ZZ6
      Conserved Domains (1) summary
      pfam10267
      Location:1 → 314
      Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

    7. XM_006506310.1 → XP_006506373.1  transmembrane and coiled-coil domains protein 1 isoform X3

      UniProtKB/Swiss-Prot
      Q69ZZ6
      Related
      ENSMUSP00000144971.2, ENSMUST00000204353.3
      Conserved Domains (1) summary
      pfam10267
      Location:52 → 459
      Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

    8. XM_036166252.1 → XP_036022145.1  transmembrane and coiled-coil domains protein 1 isoform X7

      Conserved Domains (1) summary
      pfam10267
      Location:1 → 314
      Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

    9. XM_006506312.4 → XP_006506375.1  transmembrane and coiled-coil domains protein 1 isoform X5

      Conserved Domains (1) summary
      pfam10267
      Location:47 → 454
      Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

    10. XM_006506311.5 → XP_006506374.1  transmembrane and coiled-coil domains protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A0N4SWB9
      Related
      ENSMUSP00000145456.2, ENSMUST00000173548.3
      Conserved Domains (1) summary
      pfam10267
      Location:48 → 455
      Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q69ZZ6.2 GenPept UniProtKB/Swiss-Prot:Q69ZZ6

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