Cemip cell migration inducing protein, hyaluronan binding [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cemipprovided by MGI
Official Full Name: cell migration inducing protein, hyaluronan bindingprovided by MGI
Primary source: MGI:MGI:2443629
See related: Ensembl:ENSMUSG00000052353 AllianceGenome:MGI:2443629
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hybid; Kiaa1199; 12H19.01.T7; 6330404C01Rik; 9930013L23Rik
Summary: Enables hyaluronic acid binding activity and hyalurononglucosaminidase activity. Involved in hyaluronan catabolic process. Located in clathrin-coated vesicle membrane. Is expressed in several structures, including nervous system; retina; and testis. Orthologous to human CEMIP (cell migration inducing hyaluronidase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in ovary adult (RPKM 4.8), testis adult (RPKM 1.2) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 D3; 7 48.35 cM

Exon count:: 32

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (83582065..83735893, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (83932857..84086693, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

KIAA1199 deficiency enhances skeletal stem cell differentiation to osteoblasts and promotes bone regeneration.
Title: KIAA1199 deficiency enhances skeletal stem cell differentiation to osteoblasts and promotes bone regeneration.
CEMIP (KIAA1199) regulates inflammation, hyperplasia and fibrosis in osteoarthritis synovial membrane.
Title: CEMIP (KIAA1199) regulates inflammation, hyperplasia and fibrosis in osteoarthritis synovial membrane.
Sulfated hyaluronic acid inhibits the hyaluronidase CEMIP and regulates the HA metabolism, proliferation and differentiation of fibroblasts.
Title: Sulfated hyaluronic acid inhibits the hyaluronidase CEMIP and regulates the HA metabolism, proliferation and differentiation of fibroblasts.
HYBID derived from tumor cells and tumor-associated macrophages contribute to the glioblastoma growth.
Title: HYBID derived from tumor cells and tumor-associated macrophages contribute to the glioblastoma growth.
CEMIP regulates the proliferation and migration of vascular smooth muscle cells in atherosclerosis through the WNT-beta-catenin signaling pathway.
Title: CEMIP regulates the proliferation and migration of vascular smooth muscle cells in atherosclerosis through the WNT-beta-catenin signaling pathway.
Hyaluronan Degradation by Cemip Regulates Host Defense against Staphylococcus aureus Skin Infection.
Title: Hyaluronan Degradation by Cemip Regulates Host Defense against Staphylococcus aureus Skin Infection.
KIAA1199 overexpression is an independent prognostic marker in non-small-cell lung cancer (NSCLC). KIAA1199 expression directly influences the expression of epithelial-mesenchymal transition (EMT) markers. KIAA1199 promotes invasion and migration in NSCLC via PI3K-Akt mediated EMT.
Title: KIAA1199 promotes invasion and migration in non-small-cell lung cancer (NSCLC) via PI3K-Akt mediated EMT.
CEMIP was overexpressed in human osteoarthritis (OA) cartilage and along chondrocytes dedifferentiation. CEMIP-regulated transdifferentiation of chondrocytes into "chondro-myo-fibroblasts" expressing alpha-SMA and type III collagen, two fibrosis markers. Moreover, these "chondro-myo-fibroblasts" were found in OA cartilage but not in healthy cartilage.
Title: CEMIP (KIAA1199) induces a fibrosis-like process in osteoarthritic chondrocytes.
The KIAA1199, a protein that plays a role in a HA degradation pathway independent of the canonical hyaluronidases such as PH20, is specifically expressed in tissue lesions in which HA is degraded.
Title: KIAA1199 expression and hyaluronan degradation colocalize in multiple sclerosis lesions.
KIAA1199 is overexpressed in pancreatic intraepithelial neoplasia.
Title: Identification of KIAA1199 as a Biomarker for Pancreatic Intraepithelial Neoplasia.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ER retention sequence binding	ISO Inferred from Sequence Orthology more info
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables clathrin heavy chain binding	ISO Inferred from Sequence Orthology more info
enables hyaluronic acid binding	IDA Inferred from Direct Assay more info	PubMed
enables hyaluronic acid binding	ISO Inferred from Sequence Orthology more info
enables hyalurononglucosaminidase activity	IDA Inferred from Direct Assay more info	PubMed
enables hyalurononglucosaminidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables hyalurononglucosaminidase activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on glycosyl bonds	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in hyaluronan catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in hyaluronan catabolic process	ISO Inferred from Sequence Orthology more info
involved_in hyaluronan metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within metabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-threonine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein kinase C activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein targeting to membrane	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of release of sequestered calcium ion into cytosol	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of sound	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in clathrin-coated endocytic vesicle	ISO Inferred from Sequence Orthology more info
located_in clathrin-coated pit	IEA Inferred from Electronic Annotation more info
located_in clathrin-coated vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cell migration-inducing and hyaluronan-binding protein

Names: hyaluronan binding protein involved in hyaluronan depolymerization; protein 12H19.01.T7

NP_109653.3

EC 3.2.1.35

XP_006508416.1

EC 3.2.1.35

XP_006508417.1

EC 3.2.1.35

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_030728.4 → NP_109653.3 cell migration-inducing and hyaluronan-binding protein precursor

See identical proteins and their annotated locations for NP_109653.3

Status: VALIDATED

Source sequence(s)

AC101659, AC154141, AK036809, AK162689, BC086772

Consensus CDS

CCDS21416.1

UniProtKB/Swiss-Prot

E9QJS6, Q6L9J4, Q8BI06, Q9EPQ3, Q9EPQ4

UniProtKB/TrEMBL

Q14AX8

Related

ENSMUSP00000063277.6, ENSMUST00000064174.12

Conserved Domains (4) summary

cd13938
Location:141 → 303

PANDER_like_TMEM2; PANDER-like domain of the transmembrane protein TMEM2

pfam10162
Location:47 → 165

G8; G8 domain

pfam13330
Location:325 → 403

Mucin2_WxxW; Mucin-2 protein WxxW repeating region

cl19122
Location:1205 → 1361

PANDER_like; Domains similar to the Pancreatic-derived factor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

83582065..83735893 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006508354.4 → XP_006508417.1 cell migration-inducing and hyaluronan-binding protein isoform X1

See identical proteins and their annotated locations for XP_006508417.1

UniProtKB/Swiss-Prot

E9QJS6, Q6L9J4, Q8BI06, Q9EPQ3, Q9EPQ4

UniProtKB/TrEMBL

Q14AX8

Conserved Domains (4) summary

cd13938
Location:141 → 303

PANDER_like_TMEM2; PANDER-like domain of the transmembrane protein TMEM2

pfam10162
Location:47 → 165

G8; G8 domain

pfam13330
Location:325 → 403

Mucin2_WxxW; Mucin-2 protein WxxW repeating region

cl19122
Location:1205 → 1361

PANDER_like; Domains similar to the Pancreatic-derived factor
XM_006508353.4 → XP_006508416.1 cell migration-inducing and hyaluronan-binding protein isoform X1

See identical proteins and their annotated locations for XP_006508416.1

UniProtKB/Swiss-Prot

E9QJS6, Q6L9J4, Q8BI06, Q9EPQ3, Q9EPQ4

UniProtKB/TrEMBL

Q14AX8

Conserved Domains (4) summary

cd13938
Location:141 → 303

PANDER_like_TMEM2; PANDER-like domain of the transmembrane protein TMEM2

pfam10162
Location:47 → 165

G8; G8 domain

pfam13330
Location:325 → 403

Mucin2_WxxW; Mucin-2 protein WxxW repeating region

cl19122
Location:1205 → 1361

PANDER_like; Domains similar to the Pancreatic-derived factor