Traf1 TNF receptor-associated factor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Traf1provided by MGI
Official Full Name: TNF receptor-associated factor 1provided by MGI
Primary source: MGI:MGI:101836
See related: Ensembl:ENSMUSG00000026875 AllianceGenome:MGI:101836
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4732496E14Rik
Summary: Predicted to enable enzyme binding activity; identical protein binding activity; and tumor necrosis factor receptor binding activity. Predicted to be involved in several processes, including positive regulation of NF-kappaB transcription factor activity; regulation of signal transduction; and tumor necrosis factor-mediated signaling pathway. Predicted to act upstream of or within apoptotic process. Predicted to be located in cytoplasm. Predicted to be active in cytoplasmic side of plasma membrane. Is expressed in jaw and urinary system. Orthologous to human TRAF1 (TNF receptor associated factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in spleen adult (RPKM 9.8), thymus adult (RPKM 8.2) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 B; 2 23.13 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (34831762..34851784, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (34941750..34961812, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TRAF1 improves cisplatin-induced acute kidney injury via inhibition of inflammation and metabolic disorders.
Title: TRAF1 improves cisplatin-induced acute kidney injury via inhibition of inflammation and metabolic disorders.
Cutting Edge: Negative Regulation of Inflammasome Activation by TRAF1 Can Limit Gout.
Title: Cutting Edge: Negative Regulation of Inflammasome Activation by TRAF1 Can Limit Gout.
LINC00313 alleviates osteoarthritis progression in mice through promoting TRAF1 promoter methylation and inhibiting the ASK1/JNK signaling pathway.
Title: LINC00313 alleviates osteoarthritis progression in mice through promoting TRAF1 promoter methylation and inhibiting the ASK1/JNK signaling pathway.
TRAF1 suppresses antifungal immunity through CXCL1-mediated neutrophil recruitment during Candida albicans intradermal infection.
Title: TRAF1 suppresses antifungal immunity through CXCL1-mediated neutrophil recruitment during Candida albicans intradermal infection.
these data point to an important role for 4-1BB, TRAF1, and mTOR in the persistence of CD8 effector T cells in the lung parenchyma, thereby allowing the transition to Trm.
Title: 4-1BB Regulates Effector CD8 T Cell Accumulation in the Lung Tissue through a TRAF1-, mTOR-, and Antigen-Dependent Mechanism to Enhance Tissue-Resident Memory T Cell Formation during Respiratory Influenza Infection.
TRAF1 deletion blocks lipopolysaccharide-induced JNK activation in vivo and in vitro.
Title: TRAF1 meditates lipopolysaccharide-induced acute lung injury by up regulating JNK activation.
TRAF-1-/- mice fed with high fat diet failed to gain weight, and showed improved insulin resistance, increased lipid breakdown in adipocytes and UCP-1-enabled thermogenesis.
Title: Inflammatory Pathways Regulated by Tumor Necrosis Receptor-Associated Factor 1 Protect From Metabolic Consequences in Diet-Induced Obesity.
this study shows that Traf1 gene knock-out mice show increased susceptibility to lipopolysaccharide-induced septic shock
Title: The signaling adaptor TRAF1 negatively regulates Toll-like receptor signaling and this underlies its role in rheumatic disease.
NFkappaB anti-apoptotic target genes TNF receptor-associated factor 1 (TRAF1), TNF receptor-associated factor 2 (TRAF2), cellular inhibitor of apoptosis (cIAP2), and Ferritin heavy chain (FTH1) were increased following Losartan treatment
Title: Life or death by NFκB, Losartan promotes survival in dy2J/dy2J mouse of MDC1A.
TRAF1 is a crucial early mediator of hepatic ischemia/reperfusion injury.
Title: TRAF1 is a key mediator for hepatic ischemia/reperfusion injury.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables thioesterase binding	ISO Inferred from Sequence Orthology more info
enables tumor necrosis factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables tumor necrosis factor receptor binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of NF-kappaB transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in protein K63-linked ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in tumor necrosis factor-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasmic side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of plasma membrane signaling receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: TNF receptor-associated factor 1

NP_001313530.1

EC 2.3.2.27

NP_033447.2

EC 2.3.2.27

XP_011237352.1

EC 2.3.2.27

XP_011237353.1

EC 2.3.2.27

XP_011237354.1

EC 2.3.2.27

XP_011237355.1

EC 2.3.2.27

XP_011237356.1

EC 2.3.2.27

XP_036016379.1

EC 2.3.2.27

XP_036016380.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001326601.1 → NP_001313530.1 TNF receptor-associated factor 1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AK029135, AL929068, BY209774

Consensus CDS

CCDS15956.1

UniProtKB/Swiss-Prot

P39428, Q8CE28

UniProtKB/TrEMBL

Q3UM74

Related

ENSMUSP00000130759.2, ENSMUST00000172159.8

Conserved Domains (3) summary

cd03779
Location:260 → 406

MATH_TRAF1; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF1 subfamily, TRAF domain, C-terminal MATH subdomain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of ...

TIGR02168
Location:126 → 257

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam16673
Location:180 → 237

TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain
NM_009421.4 → NP_033447.2 TNF receptor-associated factor 1

See identical proteins and their annotated locations for NP_033447.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AK029135, AL929068

Consensus CDS

CCDS15956.1

UniProtKB/Swiss-Prot

P39428, Q8CE28

UniProtKB/TrEMBL

Q3UM74

Related

ENSMUSP00000108687.2, ENSMUST00000113064.8

Conserved Domains (3) summary

cd03779
Location:260 → 406

MATH_TRAF1; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF1 subfamily, TRAF domain, C-terminal MATH subdomain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of ...

TIGR02168
Location:126 → 257

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam16673
Location:180 → 237

TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

34831762..34851784 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011239053.4 → XP_011237355.1 TNF receptor-associated factor 1 isoform X1

See identical proteins and their annotated locations for XP_011237355.1

UniProtKB/Swiss-Prot

P39428, Q8CE28

UniProtKB/TrEMBL

Q3UM74

Conserved Domains (3) summary

cd03779
Location:260 → 406

MATH_TRAF1; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF1 subfamily, TRAF domain, C-terminal MATH subdomain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of ...

TIGR02168
Location:126 → 257

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam16673
Location:180 → 237

TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain
XM_011239052.4 → XP_011237354.1 TNF receptor-associated factor 1 isoform X1

See identical proteins and their annotated locations for XP_011237354.1

UniProtKB/Swiss-Prot

P39428, Q8CE28

UniProtKB/TrEMBL

Q3UM74

Conserved Domains (3) summary

cd03779
Location:260 → 406

MATH_TRAF1; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF1 subfamily, TRAF domain, C-terminal MATH subdomain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of ...

TIGR02168
Location:126 → 257

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam16673
Location:180 → 237

TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain
XM_011239050.4 → XP_011237352.1 TNF receptor-associated factor 1 isoform X1

See identical proteins and their annotated locations for XP_011237352.1

UniProtKB/Swiss-Prot

P39428, Q8CE28

UniProtKB/TrEMBL

Q3UM74

Conserved Domains (3) summary

cd03779
Location:260 → 406

MATH_TRAF1; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF1 subfamily, TRAF domain, C-terminal MATH subdomain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of ...

TIGR02168
Location:126 → 257

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam16673
Location:180 → 237

TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain
XM_011239051.4 → XP_011237353.1 TNF receptor-associated factor 1 isoform X1

See identical proteins and their annotated locations for XP_011237353.1

UniProtKB/Swiss-Prot

P39428, Q8CE28

UniProtKB/TrEMBL

Q3UM74

Conserved Domains (3) summary

cd03779
Location:260 → 406

MATH_TRAF1; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF1 subfamily, TRAF domain, C-terminal MATH subdomain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of ...

TIGR02168
Location:126 → 257

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam16673
Location:180 → 237

TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain
XM_011239054.4 → XP_011237356.1 TNF receptor-associated factor 1 isoform X1

See identical proteins and their annotated locations for XP_011237356.1

UniProtKB/Swiss-Prot

P39428, Q8CE28

UniProtKB/TrEMBL

Q3UM74

Related

ENSMUSP00000028234.6, ENSMUST00000028234.12

Conserved Domains (3) summary

cd03779
Location:260 → 406

MATH_TRAF1; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF1 subfamily, TRAF domain, C-terminal MATH subdomain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of ...

TIGR02168
Location:126 → 257

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam16673
Location:180 → 237

TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain
XM_036160486.1 → XP_036016379.1 TNF receptor-associated factor 1 isoform X2

Conserved Domains (2) summary

cl02446
Location:260 → 287

MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...

pfam16673
Location:180 → 237

TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain
XM_036160487.1 → XP_036016380.1 TNF receptor-associated factor 1 isoform X3

UniProtKB/TrEMBL

Q8C245

Conserved Domains (1) summary

pfam16673
Location:180 → 228

TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain