Uggt1 UDP-glucose glycoprotein glucosyltransferase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Uggt1provided by MGI
Official Full Name: UDP-glucose glycoprotein glucosyltransferase 1provided by MGI
Primary source: MGI:MGI:2443162
See related: Ensembl:ENSMUSG00000037470 AllianceGenome:MGI:2443162
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GT; UGT1; Ugcgl1; 0910001L17Rik; A930007H10Rik; C820010P03Rik
Summary: Predicted to enable UDP-glucose:glycoprotein glucosyltransferase activity and unfolded protein binding activity. Predicted to be involved in ER-associated misfolded protein catabolic process and protein N-linked glycosylation via asparagine. Predicted to be located in endoplasmic reticulum lumen and endoplasmic reticulum-Golgi intermediate compartment. Predicted to be part of protein-containing complex. Predicted to be active in endoplasmic reticulum. Orthologous to human UGGT1 (UDP-glucose glycoprotein glucosyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in genital fat pad adult (RPKM 12.4), placenta adult (RPKM 11.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 B; 1 15.15 cM

Exon count:: 41

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (36179109..36283407, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (36140028..36244320, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

R1526 residue in arginine/proinsulin binding domain of UGGT1 is involved in proinsulin binding.
Title: R1526 residue in arginine/proinsulin binding domain of UGGT1 is involved in proinsulin binding.
UGGT1 retains proinsulin in the endoplasmic reticulum in an arginine dependent manner.
Title: UGGT1 retains proinsulin in the endoplasmic reticulum in an arginine dependent manner.
Loss of UGT1 expression is associated with neonatal hyperbilirubinemia.
Title: Modulation of bilirubin neurotoxicity by the Abcb1 transporter in the Ugt1-/- lethal mouse model of neonatal hyperbilirubinemia.
Increased UGGT1 levels elevated viral growth rates, while viral pathogenicity was observed to be lower in heterozygous knockout mice (Uggt1 +/- mice). These findings provide important insight on the role of UPR and host UGGT1 in regulating RNA virus replication and pathogenicity.
Title: UGGT1 enhances enterovirus 71 pathogenicity by promoting viral RNA synthesis and viral replication.
study demonstrates that UGGT1 enzymatic activity, in conjunction with lectin-like chaperones, helps to limit aggregation and polymer formation of misfolded glycoprotein substrates, decreasing their BiP association and ER stress
Title: UDP-glucose:glycoprotein glucosyltransferase (UGGT1) promotes substrate solubility in the endoplasmic reticulum.
the expression of two UGGT isoforms, UGGT1 and UGGT2 was demonstrated and both isoforms are active mouse hybridoma cells.
Title: Progesterone regulates the expression and activity of two mouse isoforms of the glycoprotein folding sensor UDP-Glc: glycoprotein glucosyltransferase (UGGT).
UGT1 aids in the folding of sequential domain-containing proteins such as prosaposin.
Title: The role of UDP-Glc:glycoprotein glucosyltransferase 1 in the maturation of an obligate substrate prosaposin.
The cysteine-rich domain of Sep15 exclusively mediates protein-protein interactions with UDP-glucose:glycoprotein glucosyltransferase.
Title: A novel cysteine-rich domain of Sep15 mediates the interaction with UDP-glucose:glycoprotein glucosyltransferase.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (1)
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH124983 (e-PCR)
- UniSTS:161805

AI448372 (e-PCR)
- UniSTS:164110

UGCGL1 (e-PCR)
- UniSTS:513861

NoName (e-PCR)
- UniSTS:234109

AI414429 (e-PCR)
- UniSTS:165069

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables UDP-glucose:glycoprotein glucosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables UDP-glucose:glycoprotein glucosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables unfolded protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables unfolded protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ERAD pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein N-linked glycosylation via asparagine	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein glycosylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum lumen	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum-Golgi intermediate compartment	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: UDP-glucose:glycoprotein glucosyltransferase 1

Names: UDP--Glc:glycoprotein glucosyltransferase; UDP-glucose ceramide glucosyltransferase-like 1; UDP-glucose:glycoprotein glucosyltransferase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_198899.2 → NP_942602.2 UDP-glucose:glycoprotein glucosyltransferase 1 precursor

See identical proteins and their annotated locations for NP_942602.2

Status: VALIDATED

Source sequence(s)

AI877337, AK044321, AK134231, AK162491, BC062936, CD808359, CK639915

Consensus CDS

CCDS48238.1

UniProtKB/Swiss-Prot

E9QQ49, Q6NV70, Q6P5E4

Related

ENSMUSP00000037930.8, ENSMUST00000046875.14

Conserved Domains (2) summary

cd06432
Location:1256 → 1503

GT8_HUGT1_C_like; The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family

pfam06427
Location:45 → 1202

UDP-g_GGTase; UDP-glucose:Glycoprotein Glucosyltransferase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

36179109..36283407 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006496062.5 → XP_006496125.1 UDP-glucose:glycoprotein glucosyltransferase 1 isoform X1

Conserved Domains (6) summary

pfam06427
Location:1108 → 1214

UDP-g_GGTase; UDP-glucose:Glycoprotein Glucosyltransferase

pfam18400
Location:57 → 237

Thioredoxin_12; Thioredoxin-like domain

pfam18401
Location:310 → 440

Thioredoxin_13; Thioredoxin-like domain

pfam18402
Location:451 → 699

Thioredoxin_14; Thioredoxin-like domain

pfam18403
Location:722 → 947

Thioredoxin_15; Thioredoxin-like domain

pfam18404
Location:1248 → 1515

Glyco_transf_24; Glucosyltransferase 24