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    Atp5mg ATP synthase membrane subunit g [ Mus musculus (house mouse) ]

    Gene ID: 27425, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Atp5mgprovided by MGI
    Official Full Name
    ATP synthase membrane subunit gprovided by MGI
    Primary source
    MGI:MGI:1351597
    See related
    Ensembl:ENSMUSG00000038717 AllianceGenome:MGI:1351597
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Atp5l; 4933437C06Rik
    Summary
    Predicted to enable P-type proton-exporting transporter activity. Predicted to contribute to proton-transporting ATP synthase activity, rotational mechanism. Predicted to be involved in ATP synthesis coupled proton transport. Predicted to act upstream of or within ATP biosynthetic process and ion transport. Located in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; central nervous system; cranium; eye; and genitourinary system. Orthologous to several human genes including ATP5MG (ATP synthase membrane subunit g). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in heart adult (RPKM 309.5), kidney adult (RPKM 211.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    9 A5.2; 9 24.84 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (44824546..44832470, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (44913248..44920742, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_23986 Neighboring gene predicted gene, 30883 Neighboring gene predicted gene, 26249 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:44728805-44728988 Neighboring gene predicted gene, 30934 Neighboring gene ubiquitination factor E4A Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class A pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:44773592-44773779 Neighboring gene CD3 antigen, gamma polypeptide

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Sequence of a cDNA encoding mouse F1F0-ATP synthase g subunit. Jeon D, et al. Biosci Biotechnol Biochem, 1999 Apr. PMID 10361692
    2. A genetic and physiological study of impaired glucose homeostasis control in C57BL/6J mice. Toye AA, et al. Diabetologia, 2005 Apr. PMID 15729571
    3. Histone deacetylase 3 controls lung alveolar macrophage development and homeostasis. Yao Y, et al. Nat Commun, 2020 Jul 30. PMID 32732898, Free PMC Article
    4. Characterization of the zinc-induced Shank3 interactome of mouse synaptosome. Lee Y, et al. Biochem Biophys Res Commun, 2017 Dec 16. PMID 29111324
    5. Characterization of the Cardiac Overexpression of HSPB2 Reveals Mitochondrial and Myogenic Roles Supported by a Cardiac HspB2 Interactome. Grose JH, et al. PLoS One, 2015. PMID 26465331, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC107313, MGC107547

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables P-type proton-exporting transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables proton transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to proton-transporting ATP synthase activity, rotational mechanism IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to proton-transporting ATP synthase activity, rotational mechanism ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within ATP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton motive force-driven ATP synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within proton motive force-driven ATP synthesis ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane HDA PubMed 
    part_of mitochondrial proton-transporting ATP synthase complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    part_of mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of proton-transporting ATP synthase complex, coupling factor F(o) IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ATP synthase subunit g, mitochondrial
    Names
    ATP synthase, H+ transporting, mitochondrial F0 complex, subunit G
    ATPase subunit g
    F1F0-ATP synthase g subunit
    NP_038823.2
    XP_036010936.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013795.5 → NP_038823.2  ATP synthase subunit g, mitochondrial

      See identical proteins and their annotated locations for NP_038823.2

      Status: VALIDATED

      Source sequence(s)
      BC086880, BY269662
      Consensus CDS
      CCDS40604.1
      UniProtKB/Swiss-Prot
      O70590, Q5M9M8, Q9CPQ8
      UniProtKB/TrEMBL
      Q9D037
      Related
      ENSMUSP00000047960.8, ENSMUST00000043675.9
      Conserved Domains (1) summary
      pfam04718
      Location:10 → 101
      ATP-synt_G; Mitochondrial ATP synthase g subunit

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      44824546..44832470 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155043.1 → XP_036010936.1  ATP synthase subunit g, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      O70590, Q5M9M8, Q9CPQ8
      UniProtKB/TrEMBL
      Q9D037
      Conserved Domains (1) summary
      pfam04718
      Location:10 → 101
      ATP-synt_G; Mitochondrial ATP synthase g subunit
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CPQ8.1 GenPept UniProtKB/Swiss-Prot:Q9CPQ8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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