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    Plrg1 pleiotropic regulator 1 [ Mus musculus (house mouse) ]

    Gene ID: 53317, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Plrg1provided by MGI
    Official Full Name
    pleiotropic regulator 1provided by MGI
    Primary source
    MGI:MGI:1858197
    See related
    Ensembl:ENSMUSG00000027998 AllianceGenome:MGI:1858197
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tango4
    Summary
    Acts upstream of or within positive regulation of G1/S transition of mitotic cell cycle and protein localization to nucleus. Predicted to be located in fibrillar center; nuclear membrane; and nuclear speck. Predicted to be part of Cul4-RING E3 ubiquitin ligase complex; Prp19 complex; and nucleus. Is expressed in several structures, including alimentary system; branchial arch; genitourinary system; hemolymphoid system; and sensory organ. Orthologous to human PLRG1 (pleiotropic regulator 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 34.5), CNS E14 (RPKM 30.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    3 E3; 3 36.99 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (82962845..82979598)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (83055538..83072291)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_08044 Neighboring gene STARR-seq mESC enhancer starr_08045 Neighboring gene STARR-positive B cell enhancer mm9_chr3:82859171-82859472 Neighboring gene predicted gene, 40075 Neighboring gene fibrinogen beta chain Neighboring gene predicted gene 10710 Neighboring gene dachsous cadherin related 2 Neighboring gene STARR-seq mESC enhancer starr_08046 Neighboring gene STARR-seq mESC enhancer starr_08047 Neighboring gene STARR-seq mESC enhancer starr_08048 Neighboring gene STARR-seq mESC enhancer starr_08049 Neighboring gene STARR-seq mESC enhancer starr_08050 Neighboring gene predicted gene, 54183

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. PLRG1 is an essential regulator of cell proliferation and apoptosis during vertebrate development and tissue homeostasis. Kleinridders A, et al. Mol Cell Biol, 2009 Jun. PMID 19307306, Free PMC Article
    2. Splicing and beyond: the many faces of the Prp19 complex. Chanarat S, et al. Biochim Biophys Acta, 2013 Oct. PMID 23742842
    3. Identification of candidate alkylator-induced cancer susceptibility genes by whole genome scanning in mice. Fenske TS, et al. Cancer Res, 2006 May 15. PMID 16707424
    4. A STUB1 ubiquitin ligase/CHIC2 protein complex negatively regulates the IL-3, IL-5, and GM-CSF cytokine receptor common β chain (CSF2RB) protein stability. Koochaki SHJ, et al. J Biol Chem, 2022 Oct. PMID 36108743, Free PMC Article
    5. Cdh1-APC Regulates Protein Synthesis and Stress Granules in Neurons through an FMRP-Dependent Mechanism. Valdez-Sinon AN, et al. iScience, 2020 May 22. PMID 32434143, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PLRG1 is a critical nuclear regulator of p53-dependent cell cycle progression and apoptosis during both embryonic development and adult tissue homeostasis.
      Title: PLRG1 is an essential regulator of cell proliferation and apoptosis during vertebrate development and tissue homeostasis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA splicing, via spliceosome NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein localization to nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of DNA replication factor A complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Prp19 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Prp19 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U2-type catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    pleiotropic regulator 1
    Names
    pleiotropic regulator 1, PRL1 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016784.3 → NP_058064.2  pleiotropic regulator 1

      See identical proteins and their annotated locations for NP_058064.2

      Status: PROVISIONAL

      Source sequence(s)
      AK077197
      Consensus CDS
      CCDS17433.1
      UniProtKB/Swiss-Prot
      O55039, Q922V4
      UniProtKB/TrEMBL
      D3Z4V1
      Related
      ENSMUSP00000114968.2, ENSMUST00000150268.8
      Conserved Domains (3) summary
      COG2319
      Location:192 → 488
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:195 → 489
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:208 → 243
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      82962845..82979598
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q922V4.1 GenPept UniProtKB/Swiss-Prot:Q922V4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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