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    Paip2 polyadenylate-binding protein-interacting protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 67869, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Paip2provided by MGI
    Official Full Name
    polyadenylate-binding protein-interacting protein 2provided by MGI
    Primary source
    MGI:MGI:1915119
    See related
    Ensembl:ENSMUSG00000037058 AllianceGenome:MGI:1915119
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2310050K10Rik
    Summary
    Enables mRNA binding activity. Acts upstream of or within several processes, including memory; negative regulation of translation; and regulation of long-term synaptic potentiation. Located in cytoplasm. Is expressed in embryo and retina. Orthologous to human PAIP2 (poly(A) binding protein interacting protein 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 36.3), CNS E14 (RPKM 35.9) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    18 B2; 18 19.16 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (35731649..35750239)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (35598610..35617186)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene microRNA 1949 Neighboring gene small nucleolar RNA, H/ACA box 74A Neighboring gene small nucleolar RNA host gene 4 Neighboring gene matrin 3 Neighboring gene STARR-positive B cell enhancer ABC_E9973 Neighboring gene STARR-positive B cell enhancer ABC_E5651 Neighboring gene solute carrier family 23 (nucleobase transporters), member 1 Neighboring gene STARR-seq mESC enhancer starr_44241 Neighboring gene STARR-seq mESC enhancer starr_44242 Neighboring gene marginal zone B and B1 cell-specific protein 1 Neighboring gene proline rich basic protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Suppression of cellular transformation by poly (A) binding protein interacting protein 2 (Paip2). Rosenfeld AB. PLoS One, 2011. PMID 21957478, Free PMC Article
    2. Control of synaptic plasticity and memory via suppression of poly(A)-binding protein. Khoutorsky A, et al. Neuron, 2013 Apr 24. PMID 23622065
    3. PABP interacting protein 2A (PAIP2A) regulates specific key proteins during spermiogenesis in the mouse. Delbes G, et al. Biol Reprod, 2012 Mar. PMID 22190698
    4. The poly(A)-binding protein partner Paip2a controls translation during late spermiogenesis in mice. Yanagiya A, et al. J Clin Invest, 2010 Sep. PMID 20739757, Free PMC Article
    5. Poly(A)-binding protein-interacting protein 2, a strong regulator of vascular endothelial growth factor mRNA. Onesto C, et al. J Biol Chem, 2004 Aug 13. PMID 15175342

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. this study demonstrated that activity-dependent degradation of PAIP2A relieves translational inhibition of memory-related genes through PABP reactivation and conclude that PAIP2A is a pivotal translational regulator of synaptic plasticity and memory.
      Title: Control of synaptic plasticity and memory via suppression of poly(A)-binding protein.
    2. PABP interacting protein 2A (PAIP2A) regulates specific key proteins during spermiogenesis in the mouse.
      Title: PABP interacting protein 2A (PAIP2A) regulates specific key proteins during spermiogenesis in the mouse.
    3. Paip2 is able to function as a tumor suppressor
      Title: Suppression of cellular transformation by poly (A) binding protein interacting protein 2 (Paip2).
    4. PAIP2 is a crucial regulator of VEGF mRNA and has a role in regulating angiogenesis
      Title: Poly(A)-binding protein-interacting protein 2, a strong regulator of vascular endothelial growth factor mRNA.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA regulatory element binding translation repressor activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables poly(A) binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables translation repressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation repressor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of translation ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in negative regulation of translational initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of long-term synaptic potentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    polyadenylate-binding protein-interacting protein 2
    Names
    PAIP-2
    Pabp-interacting protein 2
    poly(A)-binding protein-interacting protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357470.1 → NP_001344399.1  polyadenylate-binding protein-interacting protein 2

      Status: VALIDATED

      Source sequence(s)
      AC121821, AI449635
      Consensus CDS
      CCDS29143.1
      UniProtKB/Swiss-Prot
      Q3UBH5, Q9D6V8, Q9DAW7
      UniProtKB/TrEMBL
      Q3TJ84, Q3U438
      Related
      ENSMUSP00000157742.2, ENSMUST00000236020.2
      Conserved Domains (1) summary
      pfam07145
      Location:108 → 123
      PAM2; Ataxin-2 C-terminal region

    2. NM_001357471.1 → NP_001344400.1  polyadenylate-binding protein-interacting protein 2

      Status: VALIDATED

      Source sequence(s)
      AC121821, AI449635
      Consensus CDS
      CCDS29143.1
      UniProtKB/Swiss-Prot
      Q3UBH5, Q9D6V8, Q9DAW7
      UniProtKB/TrEMBL
      Q3TJ84, Q3U438
      Related
      ENSMUSP00000157456.2, ENSMUST00000236868.2
      Conserved Domains (1) summary
      pfam07145
      Location:108 → 123
      PAM2; Ataxin-2 C-terminal region

    3. NM_001357472.1 → NP_001344401.1  polyadenylate-binding protein-interacting protein 2

      Status: VALIDATED

      Source sequence(s)
      AC121821, AI449635
      Consensus CDS
      CCDS29143.1
      UniProtKB/Swiss-Prot
      Q3UBH5, Q9D6V8, Q9DAW7
      UniProtKB/TrEMBL
      Q3TJ84, Q3U438
      Related
      ENSMUSP00000157519.2, ENSMUST00000235400.2
      Conserved Domains (1) summary
      pfam07145
      Location:108 → 123
      PAM2; Ataxin-2 C-terminal region

    4. NM_001357473.1 → NP_001344402.1  polyadenylate-binding protein-interacting protein 2

      Status: VALIDATED

      Source sequence(s)
      AC121821, AEKQ02058005, AI449635
      Consensus CDS
      CCDS29143.1
      UniProtKB/Swiss-Prot
      Q3UBH5, Q9D6V8, Q9DAW7
      UniProtKB/TrEMBL
      Q3TJ84, Q3U438
      Conserved Domains (1) summary
      pfam07145
      Location:108 → 123
      PAM2; Ataxin-2 C-terminal region

    5. NM_026420.3 → NP_080696.1  polyadenylate-binding protein-interacting protein 2

      See identical proteins and their annotated locations for NP_080696.1

      Status: VALIDATED

      Source sequence(s)
      AI449635, AK009909, BB842021
      Consensus CDS
      CCDS29143.1
      UniProtKB/Swiss-Prot
      Q3UBH5, Q9D6V8, Q9DAW7
      UniProtKB/TrEMBL
      Q3TJ84, Q3U438
      Related
      ENSMUSP00000036021.9, ENSMUST00000041314.17
      Conserved Domains (1) summary
      pfam07145
      Location:108 → 123
      PAM2; Ataxin-2 C-terminal region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      35731649..35750239
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017317973.3 → XP_017173462.1  polyadenylate-binding protein-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q3UBH5, Q9D6V8, Q9DAW7
      UniProtKB/TrEMBL
      Q3TJ84, Q3U438
      Conserved Domains (1) summary
      pfam07145
      Location:108 → 123
      PAM2; Ataxin-2 C-terminal region

    2. XM_030250580.2 → XP_030106440.1  polyadenylate-binding protein-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q3UBH5, Q9D6V8, Q9DAW7
      UniProtKB/TrEMBL
      Q3TJ84, Q3U438
      Conserved Domains (1) summary
      pfam07145
      Location:108 → 123
      PAM2; Ataxin-2 C-terminal region

    3. XM_036161261.1 → XP_036017154.1  polyadenylate-binding protein-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q3UBH5, Q9D6V8, Q9DAW7
      UniProtKB/TrEMBL
      Q3TJ84, Q3U438
      Related
      ENSMUSP00000158496.2, ENSMUST00000235476.2
      Conserved Domains (1) summary
      pfam07145
      Location:108 → 123
      PAM2; Ataxin-2 C-terminal region

    4. XM_036161263.1 → XP_036017156.1  polyadenylate-binding protein-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q3UBH5, Q9D6V8, Q9DAW7
      UniProtKB/TrEMBL
      Q3TJ84, Q3U438
      Related
      ENSMUSP00000157936.2, ENSMUST00000235210.2
      Conserved Domains (1) summary
      pfam07145
      Location:108 → 123
      PAM2; Ataxin-2 C-terminal region

    5. XM_036161264.1 → XP_036017157.1  polyadenylate-binding protein-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q3UBH5, Q9D6V8, Q9DAW7
      UniProtKB/TrEMBL
      Q3TJ84, Q3U438
      Conserved Domains (1) summary
      pfam07145
      Location:108 → 123
      PAM2; Ataxin-2 C-terminal region

    6. XM_030250581.2 → XP_030106441.1  polyadenylate-binding protein-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q3UBH5, Q9D6V8, Q9DAW7
      UniProtKB/TrEMBL
      Q3TJ84, Q3U438
      Conserved Domains (1) summary
      pfam07145
      Location:108 → 123
      PAM2; Ataxin-2 C-terminal region
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D6V8.1 GenPept UniProtKB/Swiss-Prot:Q9D6V8

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