Traf3 TNF receptor-associated factor 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Traf3provided by MGI
Official Full Name: TNF receptor-associated factor 3provided by MGI
Primary source: MGI:MGI:108041
See related: Ensembl:ENSMUSG00000021277 AllianceGenome:MGI:108041
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: amn; LAP1; CAP-1; CRAF1; T-BAM; CD40bp; TRAFAMN
Summary: Enables protein kinase binding activity. Involved in several processes, including regulation of defense response to virus; regulation of gene expression; and tumor necrosis factor-mediated signaling pathway. Located in cytoplasmic side of plasma membrane. Part of CD40 receptor complex. Is expressed in several structures, including genitourinary system; hemolymphoid system gland; lower jaw epithelium; lung; and mandibular process. Human ortholog(s) of this gene implicated in brain disease. Orthologous to human TRAF3 (TNF receptor associated factor 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in spleen adult (RPKM 14.4), thymus adult (RPKM 12.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 F1; 12 60.94 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (111132799..111233589)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (111166321..111267155)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The adaptor protein TRAF3 is an immune checkpoint that inhibits myeloid-derived suppressor cell expansion.
Title: The adaptor protein TRAF3 is an immune checkpoint that inhibits myeloid-derived suppressor cell expansion.
TRAF3 suppression encourages B cell recruitment and prolongs survival of microbiome-intact mice with ovarian cancer.
Title: TRAF3 suppression encourages B cell recruitment and prolongs survival of microbiome-intact mice with ovarian cancer.
Upregulated Expression of the IL-9 Receptor on TRAF3-Deficient B Lymphocytes Confers Ig Isotype Switching Responsiveness to IL-9 in the Presence of Antigen Receptor Engagement and IL-4.
Title: Upregulated Expression of the IL-9 Receptor on TRAF3-Deficient B Lymphocytes Confers Ig Isotype Switching Responsiveness to IL-9 in the Presence of Antigen Receptor Engagement and IL-4.
TRAF3: Guardian of T lymphocyte functions.
Title: TRAF3: Guardian of T lymphocyte functions.
TNF receptor-related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF-kappaB-inducing kinase-mediated hepatocyte transdifferentiation.
Title: TNF receptor-related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF-κB-inducing kinase-mediated hepatocyte transdifferentiation.
TRAF3 plays a role in lupus nephritis by regulating Th17 cell and Treg cell balance as well as NF-kappaB signaling pathway in mice.
Title: TRAF3 plays a role in lupus nephritis by regulating Th17 cell and Treg cell balance as well as NF-κB signaling pathway in mice.
SGK1 negatively regulates inflammatory immune responses and protects against alveolar bone loss through modulation of TRAF3 activity.
Title: SGK1 negatively regulates inflammatory immune responses and protects against alveolar bone loss through modulation of TRAF3 activity.
TRAF3 promoted ROS-induced oxidative stress in model of cardiac infarction through the regulation of ULK1 ubiquitination.
Title: TRAF3 promoted ROS-induced oxidative stress in model of cardiac infarction through the regulation of ULK1 ubiquitination.
MicroRNA-494-3p prevents liver fibrosis and attenuates hepatic stellate cell activation by inhibiting proliferation and inducing apoptosis through targeting TRAF3.
Title: MicroRNA-494-3p prevents liver fibrosis and attenuates hepatic stellate cell activation by inhibiting proliferation and inducing apoptosis through targeting TRAF3.
TRAF3 in T Cells Restrains Negative Regulators of LAT to Promote TCR/CD28 Signaling.
Title: TRAF3 in T Cells Restrains Negative Regulators of LAT to Promote TCR/CD28 Signaling.

Submit: New GeneRIF Correction See all GeneRIFs (95)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation
Chemically induced (ENU) (2)
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

TRAF3_1584 (e-PCR)
- UniSTS:277842

TRAF3_v555 (e-PCR)
- UniSTS:277842

AI528849 (e-PCR)
- UniSTS:185960

D12Mit280 (e-PCR), detects polymorphism
- UniSTS:126839

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info
enables thioesterase binding	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables tumor necrosis factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables tumor necrosis factor receptor binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Toll signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of NF-kappaB transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of NF-kappaB transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of NF-kappaB transcription factor activity	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of type I interferon production	ISO Inferred from Sequence Orthology more info
involved_in protein K63-linked ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of defense response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of interferon-beta production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of proteolysis	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of proteolysis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of proteolysis	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in toll-like receptor 4 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in toll-like receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tumor necrosis factor-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in tumor necrosis factor-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tumor necrosis factor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of CD40 receptor complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasmic side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in endosome	ISO Inferred from Sequence Orthology more info
is_active_in endosome membrane	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	ISO Inferred from Sequence Orthology more info
part_of plasma membrane signaling receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: TNF receptor-associated factor 3

Names: CD40 receptor-associated factor 1; CD40-binding protein; RING-type E3 ubiquitin transferase TRAF3

NP_001273051.1

EC 2.3.2.27

NP_001351293.1

EC 2.3.2.27

NP_001409354.1

EC 2.3.2.27

NP_001409355.1

EC 2.3.2.27

NP_035762.2

EC 2.3.2.27

XP_006515862.1

EC 2.3.2.27

XP_006515863.1

EC 2.3.2.27

XP_006515865.1

EC 2.3.2.27

XP_030102544.1

EC 2.3.2.27

XP_036013273.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001286122.1 → NP_001273051.1 TNF receptor-associated factor 3 isoform b

See identical proteins and their annotated locations for NP_001273051.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an internal exon in the 5' UTR and an in-frame exon in the coding region, compared to variant 1. The resulting isoform (b) lacks an internal segment, compared to isoform a.

Source sequence(s)

AC122023, AK147362, BF661650

Consensus CDS

CCDS36563.1

UniProtKB/TrEMBL

Q3UHJ1, Q3UHM2

Related

ENSMUSP00000112517.2, ENSMUST00000117269.8

Conserved Domains (4) summary

COG1196
Location:226 → 407

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd03777
Location:352 → 537

MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...

pfam02176
Location:135 → 191

zf-TRAF; TRAF-type zinc finger

cd16640
Location:50 → 91

RING-HC_TRAF3; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) and similar proteins
NM_001364364.1 → NP_001351293.1 TNF receptor-associated factor 3 isoform b

Status: VALIDATED

Source sequence(s)

AC122023, AC127580, AK147362, CJ127244

Consensus CDS

CCDS36563.1

UniProtKB/TrEMBL

Q3UHJ1, Q3UHM2

Related

ENSMUSP00000058361.7, ENSMUST00000060274.7

Conserved Domains (4) summary

COG1196
Location:226 → 407

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd03777
Location:352 → 537

MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...

pfam02176
Location:135 → 191

zf-TRAF; TRAF-type zinc finger

cd16640
Location:50 → 91

RING-HC_TRAF3; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) and similar proteins
NM_001422425.1 → NP_001409354.1 TNF receptor-associated factor 3 isoform a

Status: VALIDATED

Source sequence(s)

AC122023, AC127580

UniProtKB/Swiss-Prot

B2RPW3, Q60803, Q62380
NM_001422426.1 → NP_001409355.1 TNF receptor-associated factor 3 isoform a

Status: VALIDATED

Source sequence(s)

AC122023, AC127580

UniProtKB/Swiss-Prot

B2RPW3, Q60803, Q62380
NM_011632.3 → NP_035762.2 TNF receptor-associated factor 3 isoform a

See identical proteins and their annotated locations for NP_035762.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (a).

Source sequence(s)

AC122023, AK147362, BC137634, BF661650, CJ127244

Consensus CDS

CCDS26175.1

UniProtKB/Swiss-Prot

B2RPW3, Q60803, Q62380

UniProtKB/TrEMBL

Q3UHM2

Related

ENSMUSP00000021706.5, ENSMUST00000021706.11

Conserved Domains (5) summary

COG1196
Location:251 → 432

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd03777
Location:377 → 562

MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...

pfam02176
Location:135 → 191

zf-TRAF; TRAF-type zinc finger

cd16640
Location:50 → 91

RING-HC_TRAF3; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) and similar proteins

cl40617
Location:196 → 246

zf-TRAF; TRAF-type zinc finger

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

111132799..111233589

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006515802.3 → XP_006515865.1 TNF receptor-associated factor 3 isoform X2

See identical proteins and their annotated locations for XP_006515865.1

UniProtKB/TrEMBL

Q3UHJ1, Q3UHM2

Conserved Domains (4) summary

COG1196
Location:226 → 407

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd03777
Location:352 → 537

MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...

pfam02176
Location:135 → 191

zf-TRAF; TRAF-type zinc finger

cd16640
Location:50 → 91

RING-HC_TRAF3; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) and similar proteins
XM_036157380.1 → XP_036013273.1 TNF receptor-associated factor 3 isoform X1

UniProtKB/Swiss-Prot

B2RPW3, Q60803, Q62380

UniProtKB/TrEMBL

Q3UHM2

Conserved Domains (5) summary

COG1196
Location:251 → 432

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd03777
Location:377 → 562

MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...

pfam02176
Location:135 → 191

zf-TRAF; TRAF-type zinc finger

cd16640
Location:50 → 91

RING-HC_TRAF3; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) and similar proteins

cl40617
Location:196 → 246

zf-TRAF; TRAF-type zinc finger
XM_006515800.3 → XP_006515863.1 TNF receptor-associated factor 3 isoform X1

See identical proteins and their annotated locations for XP_006515863.1

UniProtKB/Swiss-Prot

B2RPW3, Q60803, Q62380

UniProtKB/TrEMBL

Q3UHM2

Conserved Domains (5) summary

COG1196
Location:251 → 432

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd03777
Location:377 → 562

MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...

pfam02176
Location:135 → 191

zf-TRAF; TRAF-type zinc finger

cd16640
Location:50 → 91

RING-HC_TRAF3; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) and similar proteins

cl40617
Location:196 → 246

zf-TRAF; TRAF-type zinc finger
XM_006515799.2 → XP_006515862.1 TNF receptor-associated factor 3 isoform X1

See identical proteins and their annotated locations for XP_006515862.1

UniProtKB/Swiss-Prot

B2RPW3, Q60803, Q62380

UniProtKB/TrEMBL

Q3UHM2

Conserved Domains (5) summary

COG1196
Location:251 → 432

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd03777
Location:377 → 562

MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...

pfam02176
Location:135 → 191

zf-TRAF; TRAF-type zinc finger

cd16640
Location:50 → 91

RING-HC_TRAF3; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) and similar proteins

cl40617
Location:196 → 246

zf-TRAF; TRAF-type zinc finger
XM_030246684.2 → XP_030102544.1 TNF receptor-associated factor 3 isoform X1

UniProtKB/Swiss-Prot

B2RPW3, Q60803, Q62380

UniProtKB/TrEMBL

Q3UHM2

Conserved Domains (5) summary

COG1196
Location:251 → 432

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd03777
Location:377 → 562

MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...

pfam02176
Location:135 → 191

zf-TRAF; TRAF-type zinc finger

cd16640
Location:50 → 91

RING-HC_TRAF3; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) and similar proteins

cl40617
Location:196 → 246

zf-TRAF; TRAF-type zinc finger

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001048206.1: Suppressed sequence

Description

NM_001048206.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.