Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    B2m beta-2 microglobulin [ Mus musculus (house mouse) ]

    Gene ID: 12010, updated on 23-Jun-2021

    Summary

    Official Symbol
    B2mprovided by MGI
    Official Full Name
    beta-2 microglobulinprovided by MGI
    Primary source
    MGI:MGI:88127
    See related
    Ensembl:ENSMUSG00000060802
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ly-m1; Ly-m11; beta2-; beta2m; beta2-m
    Expression
    Broad expression in liver adult (RPKM 838.6), mammary gland adult (RPKM 675.3) and 20 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See B2m in Genome Data Viewer
    Location:
    2 E5; 2 60.55 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (121978168..121983563)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (122147687..122153082)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (121973423..121978818)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 Neighboring gene MAGE family member B3 Neighboring gene eukaryotic translation initiation factor 3, subunit J1 Neighboring gene SPG11, spatacsin vesicle trafficking associated Neighboring gene protein associated with topoisomerase II homolog 2 (yeast) Neighboring gene tripartite motif-containing 69 Neighboring gene telomere repeat binding bouquet formation protein 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables MHC class II protein complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within T cell differentiation in thymus IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in amyloid fibril formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in antibacterial humoral response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within antigen processing and presentation of peptide antigen via MHC class I IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular defense response TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cellular response to iron ion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to iron(III) ion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to nicotine ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in defense response to Gram-negative bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in defense response to Gram-positive bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in immunoglobulin production involved in immunoglobulin-mediated immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within iron ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within iron ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in learning or memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in learning or memory ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in modulation of age-related behavioral decline IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in modulation of age-related behavioral decline ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in multicellular organism development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of forebrain neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of forebrain neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of neurogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of neuron projection development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptide antigen assembly with MHC class II protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of T cell activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of T cell cytokine production ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of T cell mediated cytotoxicity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cellular senescence ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ferrous iron binding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of receptor-mediated endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transferrin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein homotetramerization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein refolding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of erythrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of iron ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of membrane depolarization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to molecule of bacterial origin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of HFE-transferrin receptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of MHC class I peptide loading complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of MHC class I protein complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of MHC class II protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space HDA PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in phagocytic vesicle membrane TAS
    Traceable Author Statement
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009735.3NP_033865.2  beta-2-microglobulin precursor

      See identical proteins and their annotated locations for NP_033865.2

      Status: VALIDATED

      Source sequence(s)
      AK019389
      Consensus CDS
      CCDS16654.1
      UniProtKB/Swiss-Prot
      P01887
      Related
      ENSMUSP00000099534.5, ENSMUST00000102476.5
      Conserved Domains (1) summary
      cd05770
      Location:24116
      IgC_beta2m; Class I major histocompatibility complex (MHC) beta2-microglobulin

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      121978168..121983563
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center