M1ap meiosis 1 associated protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: M1approvided by MGI
Official Full Name: meiosis 1 associated proteinprovided by MGI
Primary source: MGI:MGI:1315200
See related: Ensembl:ENSMUSG00000030041 AllianceGenome:MGI:1315200
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: D6Mm5e
Summary: Predicted to enable identical protein binding activity. Involved in male meiosis chromosome separation and spermatogenesis. Acts upstream of or within female gamete generation. Located in cytoplasm. Is expressed in reproductive system. Human ortholog(s) of this gene implicated in spermatogenic failure 48. Orthologous to human M1AP (meiosis 1 associated protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in testis adult (RPKM 36.8), liver E14.5 (RPKM 3.3) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 6 C3; 6 35.94 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (82923889..83007290)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (82946908..83030309)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Bi-allelic Mutations in M1AP Are a Frequent Cause of Meiotic Arrest and Severely Impaired Spermatogenesis Leading to Male Infertility.
Title: Bi-allelic Mutations in M1AP Are a Frequent Cause of Meiotic Arrest and Severely Impaired Spermatogenesis Leading to Male Infertility.
Deficiency in M1ap results in a wide range of tubular defects, which led to severe oligozoospermia and infertility.
Title: Meiosis I arrest abnormalities lead to severe oligozoospermia in meiosis 1 arresting protein (M1ap)-deficient mice.
D6Mm5e is expressed in the germ cells of the female embryo upon their initial entry into meiosis, and in male germ cells during the last stages of spermatogenesis.
Title: Expression analysis and evolutionary conservation of the mouse germ cell-specific D6Mm5e gene.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)

General gene information

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Markers

D6Umi1a (e-PCR), detects polymorphism
- UniSTS:142638

D6UmiJ16 (e-PCR), detects polymorphism
- UniSTS:260409

D6UmiJ18 (e-PCR), detects polymorphism
- UniSTS:260411

D6UmiJ19 (e-PCR), detects polymorphism
- UniSTS:260412

14.MMHAP63FRE8.seq (e-PCR)
- UniSTS:123225

D6Mit189 (e-PCR), detects polymorphism
- UniSTS:130730

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in RNA processing	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in chromatin organization	NAS Non-traceable Author Statement more info	PubMed
involved_in female gamete generation	IEP Inferred from Expression Pattern more info	PubMed
involved_in male meiosis chromosome separation	IBA Inferred from Biological aspect of Ancestor more info
involved_in male meiosis chromosome separation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiosis I	IEA Inferred from Electronic Annotation more info
involved_in spermatogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in spermatogenesis	IEP Inferred from Expression Pattern more info	PubMed
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: meiosis 1 arrest protein

Names: meiosis 1-arresting protein; spermatogenesis-associated protein 37

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.