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    Il27ra interleukin 27 receptor, alpha [ Mus musculus (house mouse) ]

    Gene ID: 50931, updated on 21-Oct-2021

    Summary

    Official Symbol
    Il27raprovided by MGI
    Official Full Name
    interleukin 27 receptor, alphaprovided by MGI
    Primary source
    MGI:MGI:1355318
    See related
    Ensembl:ENSMUSG00000005465
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CRL1; Tccr; Wsx1; WSX-1; IL-27R; zcytor1
    Expression
    Biased expression in spleen adult (RPKM 26.4), thymus adult (RPKM 23.9) and 8 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Il27ra in Genome Data Viewer
    Location:
    8; 8 C2
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (84756915..84769250, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (84030286..84042600, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (86554185..86566474, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene microRNA 1199 Neighboring gene MISP family member 3 Neighboring gene paralemmin 3 Neighboring gene predicted gene, 53445 Neighboring gene relaxin 3 Neighboring gene regulatory factor X, 1 (influences HLA class II expression) Neighboring gene microRNA 709

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytokine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables cytokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to interleukin-12 receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to interleukin-23 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables interleukin-27 receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables interleukin-27 receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within defense response to Gram-positive bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of T cell extravasation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of T-helper 17 type immune response IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of cellular extravasation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of interleukin-17 production IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of interleukin-6 production IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of tumor necrosis factor production IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of type 2 immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of T-helper 1 type immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of activated T cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of interferon-gamma production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of isotype switching to IgG isotypes IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of interleukin-12 receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of interleukin-23 receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    interleukin-27 receptor subunit alpha
    Names
    IL-27 receptor subunit alpha
    IL-27R subunit alpha
    IL-27R-alpha
    IL-27RA
    T cell cytokine receptor
    T cell cytokine receptor; cytokine receptor family, class 1 (WSXWS), member 1
    cytokine receptor family, class 1 (WSXWS), member 1
    type I T-cell cytokine receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016671.3NP_057880.2  interleukin-27 receptor subunit alpha precursor

      See identical proteins and their annotated locations for NP_057880.2

      Status: VALIDATED

      Source sequence(s)
      AK133753, BC032878, BF019826
      Consensus CDS
      CCDS22465.1
      UniProtKB/Swiss-Prot
      O70394
      UniProtKB/TrEMBL
      Q3UZN3
      Related
      ENSMUSP00000005601.8, ENSMUST00000005601.9
      Conserved Domains (1) summary
      cd00063
      Location:123222
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      84756915..84769250 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243668.2XP_030099528.1  interleukin-27 receptor subunit alpha isoform X1

      Conserved Domains (2) summary
      cd00063
      Location:123222
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl21522
      Location:315394
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    2. XM_036154161.1XP_036010054.1  interleukin-27 receptor subunit alpha isoform X3

      Conserved Domains (1) summary
      cl21522
      Location:93172
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    3. XM_011248437.3XP_011246739.1  interleukin-27 receptor subunit alpha isoform X2

      Conserved Domains (2) summary
      cd00063
      Location:123222
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl21522
      Location:315394
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    4. XM_036154162.1XP_036010055.1  interleukin-27 receptor subunit alpha isoform X4

      Conserved Domains (1) summary
      cd00063
      Location:123222
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
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